Abstract:
:The binding of hematoporphyrin (HP) to human cells of the line NHIK 3025 has been studied with the aid of microfluorometry. HP is concentrated within cells when present in Hank's balanced salt solution in the concentration range 10(-5)--3 x 10(-3) M. The time course of binding is biphasic with a rapid initial binding and a slower accumulation at times longer than 30 min. The amount bound to HP increases linearly as the cells proceed through the cell cycle and is doubled from early G1 to late G2.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Christensen T,Moan Jdoi
10.1016/0304-3835(80)90113-5subject
Has Abstractpub_date
1980-04-01 00:00:00pages
105-110issue
2eissn
0304-3835issn
1872-7980pii
0304-3835(80)90113-5journal_volume
9pub_type
杂志文章相关文献
CANCER LETTERS文献大全abstract::This aim of this study was to measure the typical free radical-induced products of DNA bases in cellular DNA of cervical cancer tissues directly irradiated by applying brachytherapy to the patients. Significant increases in the amounts of modified bases over the control level were observed in the samples isolated afte...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(98)00170-0
更新日期:1998-10-23 00:00:00
abstract::Earlier studies performed both by us and by others have demonstrated that some n-3 and n-6 fatty acids can inhibit the growth of tumour cells in vitro. Though studies done with various types of oils rich in n-3 and n-6 fatty acids did show that the tumour incidence and growth can be modified, there were relatively few...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(97)00426-6
更新日期:1998-01-30 00:00:00
abstract::Our previous studies demonstrated that dietary garlic powder supplementation inhibits N-nitrosamine induced DNA alkylation in liver and mammary tissue. The present studies compared the impact of dietary supplementation with garlic powder or two garlic constituents, water-soluble S-allyl cysteine (SAC) and oil-soluble ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(96)04160-2
更新日期:1996-04-19 00:00:00
abstract::We investigated the effects of the ethyl acetate extract of grapefruit juice (GFJ), that of orange juice (OJ) and their components on the uptake of [(3)H]vincristine into adriamycin-resistant human myelogenous leukemia cells. Its uptake was increased by the extracts of GFJ and OJ up to 7- and 3-fold, respectively, as ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(00)00549-8
更新日期:2000-11-10 00:00:00
abstract::Pancreatic cancer is one of the most devastating diseases with very poor prognosis. Only a small proportion is curable by surgical resection, whilst standard chemotherapy for patients with advanced disease has only modest effect with substantial toxicity. Therefore, there is an urgent need for the development of novel...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2013.01.035
更新日期:2013-06-01 00:00:00
abstract::Mutations in oncogenes and tumor suppressor genes confer a fitness advantage to cells that can lead to cancer. The tumor phenotype normally results from the interaction of many mutant genes making it difficult to estimate the fitness advantage provided by any oncogene, except when tumors depend on one oncogene only. W...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2010.01.020
更新日期:2010-08-01 00:00:00
abstract::The mucosal glutathione content of the gastrointestinal wall amounted to 50-60% of its concentration in the liver. GSH S-aryltransferase activity (CDNB) was very low in the glandular stomach, colon and rectum amounting to only 5% of liver enzyme activity. There was a marked postpyloric increase in GSH S-aryltransferas...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(88)90263-7
更新日期:1988-05-01 00:00:00
abstract::We investigated a role for Hedgehog signalling in colon cancer by studying transcription of members of the pathway in human colorectal carcinoma cell lines. We determined the methylation status and screened the gene encoding the Hedgehog receptor-associated protein Smoothened (SMO) for putative mutations. In three cel...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2003.10.025
更新日期:2004-04-30 00:00:00
abstract::AGR2 has evolutionarily conserved roles in development and tissue regeneration and is linked with several human cancers. The exact functions and regulation of AGR2 are poorly understood, but current data identify AGR2 as a clinically relevant factor that modulates the behavior and response of hormone-dependent cancers...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2010.12.023
更新日期:2011-05-01 00:00:00
abstract::Prevalence of human infection with Toxoplasma gondii has been increasing in China due to the increasing number of cats. However, little is known of the epidemiology of T. gondii infection in different cancer patient groups. Thus, a case-control study of 900 cancer patients and 900 controls was conducted to detect anti...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2015.01.036
更新日期:2015-04-10 00:00:00
abstract::Many isoprenylated proteins are known to participate in signal transduction, but not all have been identified. Using an in vitro prenylation screen, two human cDNAs (PTP(CAAXI) and PTP(CAAX2)) homologous to the rat PRL-1 and human OV-1 protein tyrosine phosphatase genes were identified. PTP(CAAXI) and PTP(CAAX2) were ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(96)04459-x
更新日期:1996-12-20 00:00:00
abstract::In the presence of iron, dihydroartemisinin forms free radicals and causes cell death. Since most cancer cells have high rates of iron intake, dihydroartemisinin would have selective cytotoxic effect on cancer cells. The present experiment was designed to study the effect of dihydroartemisinin and ferrous sulfate on t...
journal_title:Cancer letters
pub_type: 杂志文章
doi:
更新日期:1995-11-27 00:00:00
abstract::Chemoresistance prevents the curative cancer chemotherapy and presents a formidable challenge for both cancer researchers and clinicians. We have previously shown that miR-193a-3p promotes the multi-chemoresistance of bladder cancer cells via repressing its three target genes: SRSF2, PLAU and HIC2. Here, we showed tha...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2014.11.002
更新日期:2015-02-01 00:00:00
abstract::Obesity is one of the major modifiable risk factors in breast cancer, with obese adipose tissue showing a pathological role in breast cancer development and malignancy via the release of secretory factors, such as proinflammatory cytokines and adipocytokines. The current article focuses on visfatin and resistin, two s...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2020.10.045
更新日期:2021-02-01 00:00:00
abstract::The over-expression of N-myc down-regulated gene 1 (NDRG1) in hepatocellular carcinoma (HCC) was previously reported to correlate with vascular invasion and patient survival. Our current study aims to elucidate its functions in HCC. We found that it lacked the tumorigenic ability to promote soft agar colony formation ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2007.12.010
更新日期:2008-04-08 00:00:00
abstract::The induction of differentiation of SENCAR murine granulocyte-macrophage precursor cells (GM-CFU) by the tumor-promoting phorbol diester 12-O--tetradecanoyl-phorbol-13-acetate (TPA) was inhibited by agents reported to inhibit specific aspects of arachidonic acid metabolism. These agents included phospholipase A2 inhib...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(87)90109-1
更新日期:1987-11-01 00:00:00
abstract::The first experimental data suggesting that neoplasm development in animals might be influenced by infectious agents were published in the early 1900s. However, conclusive evidence that DNA viruses play a role in the pathogenesis of some human cancers only emerged in the 1950s, when Epstein-Barr virus (EBV) was discov...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2006.05.010
更新日期:2007-03-18 00:00:00
abstract::The carcinogenic effect of dimethylnitrosamine (DMN) s.c. injected at two different dose levels was studied in laboratory bred European hamsters (EH) and data compared to findings for captured EH. Malignant haemangioendotheliomas of the liver and kidney, hepatocellular carcinomas and cholangiocarcinomas were induced. ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(78)92972-5
更新日期:1978-01-01 00:00:00
abstract::Benzo[a]pyrene (B[a]P) metabolism and macromolecular binding have been studied in explants from 4 tissues, bladder, skin, bronchus and esophagus from 8 donors sampled within 4 h after death. Explants were incubated with [3H]benzo[a]pyrene for 24 h, then the metabolites extracted and analyzed by high-pressure liquid ch...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(83)90112-x
更新日期:1983-02-01 00:00:00
abstract::The human myelocytic leukemia cell line HL-60 is a useful model for the study of cellular differentiation. Phorbol 12-myristate 13-acetate (PMA) induces the monocyte/macrophage-like differentiation of HL-60 cells and results in growth arrest, increasing adherence. In PMA-induced differentiation of HL-60 cells, phospho...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(01)00505-5
更新日期:2001-09-28 00:00:00
abstract::Dinitropyrenes are mutagenic environmental pollutants. Of these compounds, 1,6-dinitropyrene is a potent tumorigen while 1,3-dinitropyrene appears to be weakly or non-tumorigenic. Two-electron reduction of dinitropyrenes yields nitro-nitrosopyrenes, which have been shown previously to be the major aerobic metabolites ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(92)90215-h
更新日期:1992-07-31 00:00:00
abstract::Acquired resistance to mechanisms of programmed cell death is one of the hallmarks of cancer. Human melanoma, in advanced stage, is hardly curable, due to development of several strategies that impair apoptosis induced by the death receptor and the mitochondrial pathways of apoptosis. Among these apoptosis escape stra...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2005.06.034
更新日期:2006-07-18 00:00:00
abstract::Serum alpha-N-acetylgalactosaminidase (NaGalase) is responsible for the deglycosylation of vitamin D(3)-binding protein (Gc protein). The deglycosylated Gc protein cannot be converted into major macrophage-activating factor (MAF), leading to immunosuppression. NaGalase is universally detected in a variety of cancer pa...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(00)00502-4
更新日期:2000-09-29 00:00:00
abstract::An apoptosis-inducing protein with molecular weight of 60 kDa has been purified from fetal bovine serum. The N-terminal amino acid sequence of this protein (e.g. I-P-L-D-P-V-A-G-Y-K) reveals that it is bovine fetuin, a fetal protein functioning to control embryogenesis. The apoptosis-inducing activity of fetuin is tot...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(01)00417-7
更新日期:2001-05-26 00:00:00
abstract::6-(1-Hydroxyimino-4-methylpentyl)5,8-dimethyoxy 1,4-naphthoquinone S-52 (DMNQ S-52) was reported to have cytotoxic activity against L1210 leukemia cells. In the present study, we investigated the apoptotic mechanism of DMNQ S-52 in vitro and in vivo in murine solid cancer cells. DMNQ S-52 exerted cytotoxicity against ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2005.02.042
更新日期:2006-02-20 00:00:00
abstract::The binding of [14C] azaserine or its metabolites to DNA and protein in the organs of rats and hamsters was determined at various time after treatment with [14C] azaserine. The specific activity of 14C labelling of DNA and protein was determined. Rat liver DNA and protein were most extensively labelled at 90 min post-...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(82)90092-1
更新日期:1982-05-01 00:00:00
abstract::Vaccines containing synthetic peptides derived from tumor-associated antigens (TAA) can elicit potent cytotoxic T lymphocyte (CTL) response if they are formulated in an optimal vaccine delivery system. The aim of this study was to develop a simple and effective lipid-based vaccine delivery system using P5 HER2/neu-der...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2014.09.016
更新日期:2014-12-01 00:00:00
abstract::Cancer-associated fibroblasts (CAFs) are the predominant cell type in tumor microenvironment (TM) and featured with the distinct energy metabolism reprogramming (EMR) phenotype caused by many factors such as hypoxia and growth factors. The EMR of CAFs plays a key role in biological behaviors of cancer cells including ...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2014.07.028
更新日期:2014-10-28 00:00:00
abstract::We evaluated the association between the XPD exon 10 Asp(312)Asn and exon 23 Lys(751)Gln polymorphisms and the risk of pancreatic cancer in a hospital-based study of 344 patients and 386 controls frequency matched by age, gender, and race. Stratified analyses showed ever smokers carrying the Asn(312)Asn genotype had a...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2005.12.026
更新日期:2007-01-08 00:00:00
abstract::Glutathione S-transferases (GST) alpha and pi, glutathione (GSH) and aldehyde dehydrogenase (ADH) were determined in colorectal cancer tissue specimens and in the adjacent normal colon tissue. The median contents in normal and cancer tissue were 8.1 (2.3-30.3) (5-95% quantiles) and 15.1 (5.3-50.3) microg/mg protein fo...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(98)00059-7
更新日期:1998-06-05 00:00:00