Abstract:
:This aim of this study was to measure the typical free radical-induced products of DNA bases in cellular DNA of cervical cancer tissues directly irradiated by applying brachytherapy to the patients. Significant increases in the amounts of modified bases over the control level were observed in the samples isolated after irradiation for all patients. These increases differed among patients and among products. The repair capacity and/or the amount of hypoxic cells inside the tumor may account for the different levels of modified bases. It is possible that the observed variabilities may account for the differences in clinical responses to brachytherapy.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Foksinski M,Jaruga P,Makarewicz R,Olinski Rdoi
10.1016/s0304-3835(98)00170-0keywords:
subject
Has Abstractpub_date
1998-10-23 00:00:00pages
169-73issue
1-2eissn
0304-3835issn
1872-7980pii
S0304-3835(98)00170-0journal_volume
132pub_type
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