Abstract：
:The effect of different tannin-containing aqueous solutions on the carcinogenic action of benzo(a)pyrene (BP) on the mouse skin was investigated. It was found that the appearance of tumours was accelerated in mice treated with either tea or an oak extract after a single application of BP. The time of appearance of tumours in mice treated with gallic acid or tannic acid after treatment with BP was similar to that in the group treated with BP alone. The overall incidence of tumours was similar in all five groups.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Bogovski P,Day Ndoi
10.1016/s0304-3835(77)93723-5subject
Has Abstractpub_date
1977-07-01 00:00:00pages
9-13issue
1-2eissn
0304-3835issn
1872-7980pii
S0304-3835(77)93723-5journal_volume
3pub_type
杂志文章相关文献
CANCER LETTERS文献大全abstract：:Based on the primer binding site for Phe-tRNA, human endogenous retroviruses (HERVs) have been classified as HERV-F family members, HERV-F, HERV-FXA, HERV-Fb, and HERV-Fc. The HERV-F family was expressed in human placenta preferentially. We investigated pol fragments of HERV-F family in various human tissues and cance...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2004.01.026
更新日期：2004-07-28 00:00:00
abstract：:N-nitrosobis(2-oxopropyl)amine (BOP)-induced pancreatic adenocarcinomas in Syrian hamsters produce considerable amounts of mucin. The mucin is immunogenic in rabbits and is predominately of A blood group antigenic specificity, as determined by immunodiffusion in agar gel. Indirect immunofluorescence studies with human...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(80)90053-1
更新日期：1980-10-01 00:00:00
abstract：:Recent studies indicate that gossypol possesses potent antitumor activities in vitro and in vivo. The nuclear factor-kappa B (NF-kappaB) plays an important role in tumor cell growth, proliferation, invasion, and survival. In this study, we investigated the effects and the molecular mechanisms of gossypol on NF-kappaB ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2008.01.030
更新日期：2008-06-18 00:00:00
abstract：:To understand the role of cyclooxygenase-2 (COX-2) in gastric cancer, we examined the abundance of COX-2, vascular endothelial growth factor-A (VEGF-A), and CD34 in 45 surgically resected human gastric cancers and paired normal gastric mucosa by immunohistochemical analysis. In addition, the message RNA (mRNA) express...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(03)00153-8
更新日期：2003-05-30 00:00:00
abstract：:Pseudogenes are a subclass of long non-coding (lnc) RNAs that arose from protein-coding genes, but have lost the ability to produce proteins. Pseudogenes play an important role in the pathogenesis of various tumors; however, the role of pseudogenes in hepatocellular carcinoma (HCC) is poorly understood. In this study,...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2017.07.031
更新日期：2017-10-28 00:00:00
abstract：:We conducted a pilot study to assess the feasibility using the Electoral Register to carry out a cervical cancer screening programme on a Health District basis. A random sample of 500 names and addresses were drawn from a computerised list of the Electoral Register from three Electoral Wards in Oxford. A pilot study s...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(85)90039-4
更新日期：1985-09-30 00:00:00
abstract：:Gastric juice ascorbic acid concentrations were examined in black and white patients. Significantly lower concentrations were found in blacks, in the absence of a significant difference in the plasma concentration of vitamin C between races. Blacks had higher prevalence of Helicobacter pylori infection, higher gastric...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(94)90336-0
更新日期：1994-08-15 00:00:00
abstract：:We have investigated the effects of hyperthermia on the apoptosis induced by tumor necrosis factor alpha (TNF-alpha). Confluent monolayers of human gastric cancer cell line MKN45 were either treated or untreated with hyperthermia for 1 h. The cells were subsequently stimulated with TNF-alpha. A 24-h incubation with TN...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(03)00463-4
更新日期：2003-11-10 00:00:00
abstract：:Stromal factors play a critical role in the development of the mammary gland. Using a three dimensional-coculture model we demonstrate a significant role for stromal fibroblasts in the regulation of normal mammary epithelial morphogenesis and the control of tumor growth. Both soluble factors secreted by fibroblasts an...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2012.06.014
更新日期：2012-12-28 00:00:00
abstract：:The effect of dose was evaluated for the bladder carcinogenicity of N-[4-(5-nitro-2-furyl)-2-thiazolyl] formamide (FANFT). The chemical was fed to male weanling F344 rats for 30 weeks followed by 74 weeks of control diet. The incidences of bladder carcinoma were 100, 100, 87, 0, 0 and 0% for doses of 0.2, 0.1, 0.05, 0...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(83)90234-3
更新日期：1983-04-01 00:00:00
abstract：:Tumor biopsies obtained from 25 Saudi Arab patients with nasopharyngeal carcinoma (NPC) were examined for the presence of Epstein-Barr virus (EBV) DNA detected by the polymerase chain reaction (PCR) and for the incidence of p53 mutations screened by a combination of PCR, single strand conformation polymorphism (SSCP) ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(94)90011-6
更新日期：1994-07-29 00:00:00
abstract：:A Mr 60,000 protein, detected by its ability to induce the release of RNA from isolated nuclei, is present in the plasma of tumor-bearing and carcinogen-treated rats, together with low amounts of 2 messenger RNA transport proteins identified earlier in normal cells. The Mr 60,000 protein has been identified in tumor c...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(83)90025-3
更新日期：1983-10-01 00:00:00
abstract：:In all organisms, heat-shock proteins (HSPs) provide an ancient defense system. These proteins act as molecular chaperones by assisting proper folding and refolding of misfolded proteins and aid in the elimination of old and damaged cells. HSPs include Hsp100, Hsp90, Hsp70, Hsp40, and small HSPs. Through its substrate...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2016.01.056
更新日期：2016-04-28 00:00:00
abstract：:Although pectenotoxin-2 (PTX-2) is known to modify the actin cytoskeleton, very little is known about its apoptosis mechanism. In this study, we investigated whether PTX-2 induces apoptotic effects through suppression of the NF-kappaB signaling pathway in several leukemia cell types. PTX-2 significantly induced growth...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2008.05.034
更新日期：2008-11-18 00:00:00
abstract：:The carcinogenic effect of dimethylnitrosamine (DMN) s.c. injected at two different dose levels was studied in laboratory bred European hamsters (EH) and data compared to findings for captured EH. Malignant haemangioendotheliomas of the liver and kidney, hepatocellular carcinomas and cholangiocarcinomas were induced. ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(78)92972-5
更新日期：1978-01-01 00:00:00
abstract：:Although the incidence is very low, the prognosis of anaplastic carcinoma of the thyroid is very poor regardless of the results of various therapeutic trials. We found that the mechanism of anti-cancer drug resistance in anaplastic carcinoma of the thyroid was not explicable only in terms of expression of the mdr1 and...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(94)90010-8
更新日期：1994-07-29 00:00:00
abstract：:The mucosal glutathione content of the gastrointestinal wall amounted to 50-60% of its concentration in the liver. GSH S-aryltransferase activity (CDNB) was very low in the glandular stomach, colon and rectum amounting to only 5% of liver enzyme activity. There was a marked postpyloric increase in GSH S-aryltransferas...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(88)90263-7
更新日期：1988-05-01 00:00:00
abstract：:Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest of all solid tumours and more effective therapy is urgently needed. The stroma is thought to play a critical role in tumour development and metastasis, and high stromal expression of the matricellular protein SPARC has been robustly associated with poor p...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2020.02.031
更新日期：2020-05-01 00:00:00
abstract：:Pancreatic expression of the p53 tumor suppressor gene was studied in pancreatic adenocarcinomas and chronic pancreatitis. By immunohistochemistry, 16 of 34 (47%) cancers and none of the 24 chronic pancreatitis samples revealed nuclear staining. Sequence analysis indicated that 8 of 24 (33%) cancers were mutated for t...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(93)90168-9
更新日期：1993-05-14 00:00:00
abstract：:One of the most promising strategies to increase the efficacy of standard chemotherapy drugs is by combining them with low doses of histone deacetylases inhibitors (HDACis). Regarded as chemosensitizers, the addition of well-tolerated doses of HDACis to platinum-based chemotherapeutics has been proven in vitro and in ...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2012.09.018
更新日期：2013-02-01 00:00:00
abstract：:The alkylation of hamster liver, lung and pancreas DNA by [1-14C]- and [2,3-14C]N-nitrosobis (2-oxopropyl) amine (BOP) has been examined. The specific activity of pancreas DNA after [2,3-14C]BOP administration was only 2% of that when [1-14C]BOP was given. 7-Methylguanine, but not O-6-methylguanine, was found in hydro...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(81)90116-6
更新日期：1981-01-01 00:00:00
abstract：:The incidence of carcinomas highly increases with age. However, the initial steps of the age-related molecular carcinogenic processes remain poorly characterized. We previously showed that normal human epidermal keratinocytes spontaneously and systematically escape from senescence to give rise to preneoplastic emergin...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2018.09.008
更新日期：2018-12-01 00:00:00
abstract：:Transcripts from the murine gene family proliferin, which are increased by a wide assortment of chemical promoters of C3H10T1/2 cell morphological transformation, were shown to be induced by tri-n-butyltin chloride at concentrations above 50 nM. Two-stage transformation assays, with 3-methylcholanthrene as inducer and...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(93)90112-m
更新日期：1993-07-30 00:00:00
abstract：:To date, dozens of melanoma-associated antigens (MAGE) have been identified. Based on the differences in tissue-specific gene expression and gene structure, the MAGE family has been divided into two big subfamilies: MAGE-I and MAGE-II. MAGE-I genes were identified as a group of highly attractive targets for cancer imm...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2010.10.021
更新日期：2011-03-28 00:00:00
abstract：:Two human prostate tumor cell lines which exhibit a 2.4-fold difference in sensitivity to cis-platinum (cis-Pt) were found to possess slightly different sulphydryl contents, and the presence of a metallothionein-like zinc-binding protein was demonstrated in the line exhibiting relative resistance to cis-Pt. Although t...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(86)90007-8
更新日期：1986-05-01 00:00:00
abstract：:FHIT is a tumour suppressor gene which is frequently inactivated in different types of cancer. Both genetic (mutations, deletions, chromosomal rearrangements) and epigenetic (aberrant methylation of the 5'CpG island) alterations of the FHIT gene have been reported in various malignancies. Yet little is known about the...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2008.02.036
更新日期：2008-07-08 00:00:00
abstract：:Colorectal cancer (CRC) is one of the most common neoplasms and a leading cause of death related to cancer worldwide. Hereditary nonpolyposis colorectal cancer (HNPCC) is the most frequent autosomal dominant predisposition to the development of CRC, accounting for approximately 2.5% of the total CRC burden in Spain. G...
journal_title：Cancer letters
pub_type： 杂志文章,多中心研究
doi：10.1016/j.canlet.2005.01.036
更新日期：2005-07-08 00:00:00
abstract：:Free hematoporphyrin administered intravenously to healthy rabbits (1-28 mg/kg body weight) is bound by the 3 major lipoprotein components of plasma (VLDL, LDL and HDL) with different efficiency. In vitro-prepared complexes of hematoporphyrin (Hp) with lipoprotein fractions isolated from mouse serum have been injected...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(86)90112-6
更新日期：1986-08-01 00:00:00
abstract：:Glioblastoma (GBM) has limited therapeutic options. DNA repair mechanisms contribute GBM cells to escape therapies and re-establish tumor growth. Multiple studies have shown that POLD2 plays a critical role in DNA replication, DNA repair and genomic stability. We demonstrate for the first time that POLD2 is highly exp...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2020.01.011
更新日期：2020-07-10 00:00:00
abstract：:ArgBP2 is a multi-adapter protein involved in signal transduction associated to the cytoskeleton and was shown to regulate the migration and adhesion of pancreatic cancer cells thereby modulating their tumorigenicity. Here we describe the interaction of ArgBP2 with CIP4, a new associated protein identified by yeast tw...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2009.06.030
更新日期：2010-02-01 00:00:00
