Abstract：
:Pancreatic expression of the p53 tumor suppressor gene was studied in pancreatic adenocarcinomas and chronic pancreatitis. By immunohistochemistry, 16 of 34 (47%) cancers and none of the 24 chronic pancreatitis samples revealed nuclear staining. Sequence analysis indicated that 8 of 24 (33%) cancers were mutated for the p53 gene. Point substitutions occurred at codons 35, 105, 133, 213, 213, 258, and 299. A three base-pair in-frame insertion was identified between codons 261 and 262. None of 8 chronic pancreatitis samples exhibited p53 gene mutations. These data support a role for p53 gene alterations in human pancreatic cancer, and suggest that loss of its regulatory functions may constitute one of the differences between pancreatic cancer and chronic pancreatitis.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Casey G,Yamanaka Y,Friess H,Kobrin MS,Lopez ME,Buchler M,Beger HG,Korc Mdoi
10.1016/0304-3835(93)90168-9subject
Has Abstractpub_date
1993-05-14 00:00:00pages
151-60issue
3eissn
0304-3835issn
1872-7980pii
0304-3835(93)90168-9journal_volume
69pub_type
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