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Combination therapy: histone deacetylase inhibitors and platinum-based chemotherapeutics for cancer.

Abstract：

:One of the most promising strategies to increase the efficacy of standard chemotherapy drugs is by combining them with low doses of histone deacetylases inhibitors (HDACis). Regarded as chemosensitizers, the addition of well-tolerated doses of HDACis to platinum-based chemotherapeutics has been proven in vitro and in vivo in recent studies for many cancer types and stages. In this review, we discuss the most commonly used combinations of histone deacetylase inhibitors and platinum based drugs in the context of their possible mechanisms, efficiency, efficacy, and related drawbacks in preclinical and clinical studies.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Diyabalanage HV,Granda ML,Hooker JM

doi

10.1016/j.canlet.2012.09.018

subject

Has Abstract

pub_date

2013-02-01 00:00:00

pages

1-8

issue

1

eissn

0304-3835

issn

1872-7980

pii

S0304-3835(12)00567-8

journal_volume

329

pub_type

杂志文章,评审

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