Abstract:
:Pancreatic adenocarcinoma cells show characteristics of macrophages as phagocytosis and exocytosis. These phagocytic activities can be inhibited in macrophages by antirheumatic drugs, e.g. gold compounds and antimalarials. We have now tested the activity of auranofin and chloroquine to inhibit growth of a pancreatic tumor cell line (PaTu II) and of human foreskin fibroblasts (HFF) as a control. We found that auranofin (greater than or equal to 2 microM) inhibits both PaTu II cell and HFF growth. In contrast, chloroquine (4-18 microM) selectively interferes with the growth of PaTu II cells. This specific vulnerability of PaTu II cells was confirmed in cocultures of tumor cells and fibroblasts.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Zeilhofer HU,Mollenhauer J,Brune Kdoi
10.1016/0304-3835(89)90109-2subject
Has Abstractpub_date
1989-01-01 00:00:00pages
61-6issue
1eissn
0304-3835issn
1872-7980pii
0304-3835(89)90109-2journal_volume
44pub_type
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