当前位置： SCI文献检索 > CANCER LETTERS期刊下所有文献 > Immunization with liposome-anchored pegylated peptides modulates doxorubicin sensitivity in P-glycoprotein-expressing P388 cells.

Immunization with liposome-anchored pegylated peptides modulates doxorubicin sensitivity in P-glycoprotein-expressing P388 cells.

Abstract：

:The clinical use of chemotherapy in cancer treatment is limited by the occurrence of multidrug resistance (MDR) associated with the overexpression of membrane transporters, one of the best known is P-glycoprotein (Pgp), that actively expels drugs out of tumor cells. To overcome Pgp-mediated MDR, synthetic peptides corresponding to fragments from extracellular loops 1, 2 and 4 of the murine Pgp were coupled to polyethylene glycol-distearoylphosphatidylethanolamine and inserted into empty or monophosphoryl lipid A-containing liposomes. This formulation elicited specific antibodies which blocked Pgp-mediated efflux of doxorubicin, resulting in increased intracellular drug accumulation and subsequent potentiation of the cytotoxic effect of doxorubicin on multidrug-resistant P388 (P388R) cells. Previous immunizations with MDR1 peptides improved the efficiency of chemotherapy against P388R cells in vivo, with an increase of 83% of mice survival time. Overall, these results suggest that this approach can modulate Pgp activity by blocking drug efflux and may have clinical relevance as an alternative strategy to toxic chemosensitizers in drug-resistant cancer therapy.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Gatouillat G,Odot J,Balasse E,Nicolau C,Tosi PF,Hickman DT,López-Deber MP,Madoulet C

doi

10.1016/j.canlet.2007.04.001

subject

Has Abstract

pub_date

2007-11-18 00:00:00

pages

165-71

issue

2

eissn

0304-3835

issn

1872-7980

pii

S0304-3835(07)00175-9

journal_volume

257

pub_type

杂志文章

相关文献

CANCER LETTERS文献大全
  • Difluoro-phenyl-ethyl(4-aminopropylamidinohydrazone): an irreversible inhibitor for both ornithine and S-adenosylmethionine decarboxylases and its effect on human lymphoid leukemia Molt 4B cells.

    abstract：:Difluoro-phenyl-ethyl(4-aminopropylamidinohydrazone) (DFPA) was synthesized as an irreversible inhibitor of ornithine and S-adenosylmethionine decarboxylases and analyzed for antiproliferative effects on leukemia cells. The compound irreversibly inhibited ornithine and S-adenosylmethione decarboxylases. This inhibitio...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(88)90096-1

    authors： Hibasami H,Sakurai M,Maekawa S,Murata T,Nakashima K

    更新日期：1988-03-01 00:00:00

  • Inhibitory effect of melatonin on 7, 12-dimethylbenz[a]anthracene-induced carcinogenesis of the uterine cervix and vagina in mice and mutagenesis in vitro.

    abstract：:Forty female CBA mice aged 3-4 months were exposed twice a week during 2 months to intravaginal applications of polyurethane sponges impregnated with 0.1% solution of 7,12-dimethylbenz[a]anthracene (DMBA) in triethyleneglycol. Three hours after each application the sponges were taken out. Starting from the day of the ...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(00)00463-8

    authors： Anisimov VN,Zabezhinski MA,Popovich IG,Zaripova EA,Musatov SA,Andre V,Vigreux C,Godard T,Sichel F

    更新日期：2000-08-11 00:00:00

  • Apoptosis induced by the sonomechanical effects of low intensity pulsed ultrasound in a human leukemia cell line.

    abstract：:To obtain an optimal condition for ultrasound (US)-induced apoptosis that could be useful for cancer therapy, we applied low intensity pulsed US to sonicate U937 cells in vitro. Cells were then incubated at different time intervals before measuring apoptosis. The apoptosis was assessed by DNA fragmentation and phospha...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2004.08.034

    authors： Feril LB Jr,Kondo T,Cui ZG,Tabuchi Y,Zhao QL,Ando H,Misaki T,Yoshikawa H,Umemura S

    更新日期：2005-04-28 00:00:00

  • Cancer chemopreventive activity of 3beta-methoxyserrat-14-en-21beta-ol and several serratane analogs on two-stage mouse skin carcinogenesis.

    abstract：:3beta-Methoxyserrat-14-en-21beta-ol (1) and 3alpha-methoxyserrat-14-en-21beta-ol (2) are the most abundant triterpenoids from two Picea plants, Picea jezoensis (Sieb. et Zucc.) Carr. var. jezoensis and P. jezoensis (Sieb. et Zucc.) Carr. hondoensis (Mayr) Rehder, and the total yield of 1 and 2 reach over 1/3 of the ch...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2004.04.015

    authors： Tanaka R,Shanmugasundaram K,Yamaguchi C,Ishikawa Y,Tokuda H,Nishide K,Node M

    更新日期：2004-10-28 00:00:00

  • Early or late antibiotic intervention prevents Helicobacter pylori-induced gastric cancer in a mouse model.

    abstract：:H. pylori infection causes gastritis, peptic ulcers and gastric cancer. Eradicating H. pylori prevents ulcers, but to what extent this prevents cancer remains unknown, especially if given after intestinal metaplasia has developed. H. pylori infected wild-type (WT) mice do not develop cancer, but mice lacking the tumor...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2015.01.028

    authors： Zhang S,Lee DS,Morrissey R,Aponte-Pieras JR,Rogers AB,Moss SF

    更新日期：2015-04-10 00:00:00

  • Glutathione S-transferase-placental form expression and proliferation of hepatocytes in fumonisin B1-treated male and female Sprague-Dawley rats.

    abstract：:Fumonisin B1 (FB1), a mycotoxin produced by a common corn contaminant Fusarium moniliforme and a hepatocarcinogen in rats, has been previously suggested to act as a poor initiator, but a better promoter of gamma-glutamyltranspeptidase (GGT)-positive rat liver preneoplastic lesions. Using glutathione S-transferase-plac...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(98)00046-9

    authors： Mehta R,Lok E,Rowsell PR,Miller JD,Suzuki CA,Bondy GS

    更新日期：1998-06-05 00:00:00

  • Improved chemosensitivity in cervical cancer to cisplatin: synergistic activity of mahanine through STAT3 inhibition.

    abstract：:Toxicity reduction of cisplatin is necessary for improved treatment of cancer. Here we have demonstrated the synergistic growth-inhibitory effect of cisplatin on cervical cancer cells in-combination with a nontoxic herbal carbazole alkaloid, mahanine. Mahanine enhanced cisplatin-induced apoptosis and reduced its effec...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2014.05.005

    authors： Das R,Bhattacharya K,Samanta SK,Pal BC,Mandal C

    更新日期：2014-08-28 00:00:00

  • Stabilization and quantitative analysis of fecapentaenes in human feces, using synthetic fecapentaene-12.

    abstract：:Naturally occurring fecal mutagens, called fecapentaenes, are hypothesized to contribute to large bowel carcinogenesis. To understand health risks it is necessary to relate fecal mutagen concentrations to intestinal pathologies, i.e. colon cancer. However, fast and reliable methods for analysis of stool for fecapentae...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(89)90104-3

    authors： Kleinjans JC,Pluijmen MH,Hageman GJ,Verhagen H

    更新日期：1989-01-01 00:00:00

  • Up-regulation of NG2 proteoglycan and interferon-induced transmembrane proteins 1 and 3 in mouse astrocytoma: a membrane proteomics approach.

    abstract：:Although brain tumors are classified as if their lineage were well understood, the relationship between the molecular events that specify neural cell lineage and brain tumors remains enigmatic. Traditionally, cell surface membrane antigens have served as biomarkers that distinguish brain tumor origin and malignancy. I...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2008.01.007

    authors： Seyfried NT,Huysentruyt LC,Atwood JA 3rd,Xia Q,Seyfried TN,Orlando R

    更新日期：2008-05-18 00:00:00

  • Involvement of free radicals in the formation of heterocyclic amines and prevention by antioxidants.

    abstract：:It was found that free radical intermediates, pyrazine cation radial and carbon-centered radicals, generated in the Maillard reaction of sugars/amino acids, were involved in the production of mutagenic and carcinogenic imidazoquinoquizaline heterocyclic amines. Prevention of the generation of these radical intermediat...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(99)00140-8

    authors： Kikugawa K

    更新日期：1999-09-01 00:00:00

  • Lack of initiating and promoting activity of thiourea in rat liver foci bioassay.

    abstract：:Thiourea (TU) fails to enhance the incidence of foci deficient in adenosine-5'-triphosphatase (ATPase) either by initiation or by promotion in a rat liver foci bioassay. To weanling female Sprague-Dawley rats, 3 x 200 or 3 x 500 mg/kg body wt of TU, respectively, were applied for initiation. One week later Clophen A 5...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(88)90284-4

    authors： Oesterle D,Deml E

    更新日期：1988-08-30 00:00:00

  • Co-expression of p53 and bcl-2 may correlate to the presence of epstein-barr virus genome and the expression of proliferating cell nuclear antigen in nasopharyngeal carcinoma.

    abstract：:Epstein-Barr virus (EBV) has been well documented in the aetiology of nasopharyngeal carcinoma (NPC), although its role as well as the genetic basis in the genesis of NPC have not been elucidated. The p53 gene mutations are infrequently found in NPC, but the expression of p53 protein, as well as bcl-2 oncoprotein, has...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(00)00582-6

    authors： Niemhom S,Kitazawa S,Murao S,Kunachak S,Maeda S

    更新日期：2000-11-28 00:00:00

  • Stress-induced upregulation of TNFSF4 in cancer-associated fibroblast facilitates chemoresistance of lung adenocarcinoma through inhibiting apoptosis of tumor cells.

    abstract：:Stress conditions induced by routine treatments might affect cancer-associated fibroblasts in lung adenocarcinoma. The present study tried to explore transcriptome changes in lung fibroblasts under chemotherapeutics, irradiation, and hypoxia, which were induced by chemotherapy, radiotherapy, and anti-angiogenesis ther...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2020.10.032

    authors： Li Y,Chen Y,Miao L,Wang Y,Yu M,Yan X,Zhao Q,Cai H,Xiao Y,Huang G

    更新日期：2021-01-28 00:00:00

  • AXIN1 and AXIN2 variants in gastrointestinal cancers.

    abstract：:Mutations in the APC (adenomatous polyposis coli) gene, which encodes a multi-functional protein with a well-defined role in the canonical Wnt pathway, underlie familial adenomatous polypsosis, a rare, inherited form of colorectal cancer (CRC) and contribute to the majority of sporadic CRCs. However, not all sporadic ...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2014.09.018

    authors： Mazzoni SM,Fearon ER

    更新日期：2014-12-01 00:00:00

  • RAD51, genomic stability, and tumorigenesis.

    abstract：:Genomic instability is characteristic of malignant cells, and a strong correlation exists between abnormal karyotype and tumorigenicity. Increased expression of the homologous recombination and DNA repair protein Rad51 has been reported in immortalized cell lines and multiple primary tumor cell types which could alter...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2004.08.009

    authors： Richardson C

    更新日期：2005-02-10 00:00:00

  • 2-Methoxyestradiol synergizes with sorafenib to suppress hepatocellular carcinoma by simultaneously dysregulating hypoxia-inducible factor-1 and -2.

    abstract：:Sorafenib is the approved systemic drug of choice for advanced hepatocellular carcinoma (HCC), but has demonstrated limited benefits because of drug resistance. 2-Methoxyestradiol (2ME2) has been shown to be a promising anticancer drug against various types of cancers and acts by dysregulating hypoxia-inducible factor...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2014.09.011

    authors： Ma L,Li G,Zhu H,Dong X,Zhao D,Jiang X,Li J,Qiao H,Ni S,Sun X

    更新日期：2014-12-01 00:00:00

  • DNA viruses in human cancer: an integrated overview on fundamental mechanisms of viral carcinogenesis.

    abstract：:The first experimental data suggesting that neoplasm development in animals might be influenced by infectious agents were published in the early 1900s. However, conclusive evidence that DNA viruses play a role in the pathogenesis of some human cancers only emerged in the 1950s, when Epstein-Barr virus (EBV) was discov...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2006.05.010

    authors： Elgui de Oliveira D

    更新日期：2007-03-18 00:00:00

  • Epigenetic silencing of HOPX contributes to cancer aggressiveness in breast cancer.

    abstract：:Epigenetic silencing of HOPX has been shown to be frequent and specific in human cancers. HOPX is thought as a tumor suppressor gene and its promoter methylation is the main mechanism of down-regulation. In non-hereditary breast cancer, since roles of epigenetic modifications are more critical than in other cancers, t...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2016.10.017

    authors： Kikuchi M,Katoh H,Waraya M,Tanaka Y,Ishii S,Tanaka T,Nishizawa N,Yokoi K,Minatani N,Ema A,Kosaka Y,Tanino H,Yamashita K,Watanabe M

    更新日期：2017-01-01 00:00:00

  • piR-823, a novel non-coding small RNA, demonstrates in vitro and in vivo tumor suppressive activity in human gastric cancer cells.

    abstract：:Piwi-interacting RNAs (piRNAs), new non-coding small RNAs, are association with chromatin organization, messenger RNA stability and genome structure. However, the roles of piRNA in carcinogenesis are not clearly defined. By using real-time reverse transcription-polymerase chain reaction technology, we found that the e...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2011.10.004

    authors： Cheng J,Deng H,Xiao B,Zhou H,Zhou F,Shen Z,Guo J

    更新日期：2012-02-01 00:00:00

  • Frequent loss of heterozygosity on multiple chromosomes in Chinese esophageal squamous cell carcinomas.

    abstract：:Analysis of the loss of heterozygosity (LOH) detected by polymerase chain reaction techniques using 18 polymorphic markers localized to chromosomes 3p, 5, 17, and 18q in 40 Hong Kong Chinese esophageal squamous cell carcinoma (ESC) patients showed that multiple alterations on several chromosomes are involved in ESC de...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(01)00577-8

    authors： Ko JM,Wong CP,Tang CM,Lau KW,Lung ML

    更新日期：2001-09-20 00:00:00

  • Are retroviruses involved in the aetiology of human breast cancer?

    abstract：:To further investigate the possibility for retroviral involvement in the etiology of human breast cancer we processed peripheral blood monocytes and malignant breast tissue biopsies from 10 patients with breast cancer (infiltrating ductal carcinoma or infiltrating lobular carcinoma; ages 40-80 years) and 20 normal hea...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(96)04217-6

    authors： Hughes G,McKerr G,Allen J,Barnett Y

    更新日期：1996-06-05 00:00:00

  • Inhibition of azoxymethane-induced intestinal cancer by disulfiram.

    abstract：:Sprague--Dawley rats, both intact and colostomized animals, were given 24 weekly injections of azoxymethane. Rats were fed either Rat Purina Chow or the same diet plus 0.25% disulfiram. In the intact animals, disulfiram reduced tumors from an average of 6.3 to 0.95. The number of rats developing tumors was reduced fro...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(78)80050-0

    authors： Nigro ND,Campbell RL

    更新日期：1978-08-01 00:00:00

  • Use of IL-2 gene transfer in local immunotherapy of cancer.

    abstract：:Insertion of functional interleukin-2 (IL-2) gene into a plasmacytoma cell line X63-Ag8.653 substantially reduced tumorigenicity of the resulting cloned cells, designated as X63-m-IL-2. Peritumoral administration of the X63-m-IL-2 cells, producing constitutively large quantities of IL-2, resulted in regressions of est...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(92)90104-4

    authors： Bubeník J,Lotzová E,Indrová M,Símová J,Jandlová T,Bubeníková D

    更新日期：1992-03-15 00:00:00

  • Growth inhibition of a prostate tumor by alpha-difluoromethylornithine and by cyclophosphamide.

    abstract：:The effects of the ornithine decarboxylase suicide substrate, difluoromethylornithine (DFMO), and of cyclophosphamide, individually and in combination, on the growth of the R3327MAT-Lu prostate derived tumor were determined. DFMO decreased the growth rate and resulted in a 75% reduction in DNA content compared to the ...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(82)90093-3

    authors： Heston WD,Kadmon D,Fair WR

    更新日期：1982-05-01 00:00:00

  • Non-targeted effects induced by ionizing radiation: mechanisms and potential impact on radiation induced health effects.

    abstract：:Not-targeted effects represent a paradigm shift from the "DNA centric" view that ionizing radiation only elicits biological effects and subsequent health consequences as a result of an energy deposition event in the cell nucleus. While this is likely true at higher radiation doses (>1 Gy), at low doses (<100 mGy) non-...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2013.09.009

    authors： Morgan WF,Sowa MB

    更新日期：2015-01-01 00:00:00

  • Identification of human acinar cell carcinoma by monoclonal antibody and in vitro differentiation.

    abstract：:Methylnitrosourea (MNU)-induced carcinomas in organ-cultured human pancreas when injected into nude mice produced subcutaneous carcinomas none of which recognizable as being of acinar cell origin. Both monoclonal antibody to acinar cell surface marker produced by hybridoma, and in vitro tumor cell differentiation were...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(82)90040-4

    authors： Parsa I

    更新日期：1982-02-01 00:00:00

  • Oral artemisinin prevents and delays the development of 7,12-dimethylbenz[a]anthracene (DMBA)-induced breast cancer in the rat.

    abstract：:Artemisinin, a compound isolated from the sweet wormwood Artemisia annua L., has previously been shown to have selective toxicity towards cancer cells in vitro. In the present experiment, we studied the potential of artemisinin to prevent breast cancer development in rats treated with a single oral dose (50mg/kg) of 7...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2005.01.019

    authors： Lai H,Singh NP

    更新日期：2006-01-08 00:00:00

  • Progesterone receptor membrane component 1 deficiency attenuates growth while promoting chemosensitivity of human endometrial xenograft tumors.

    abstract：:Endometrial cancer is the leading gynecologic cancer in women in the United States with 52,630 women predicted to be diagnosed with the disease in 2014. The objective of this study was to determine if progesterone (P4) receptor membrane component 1 (PGRMC1) influenced endometrial cancer cell viability in response to c...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2014.09.036

    authors： Friel AM,Zhang L,Pru CA,Clark NC,McCallum ML,Blok LJ,Shioda T,Peluso JJ,Rueda BR,Pru JK

    更新日期：2015-01-28 00:00:00

  • Epigallocatechin-3-gallate effectively attenuates skeletal muscle atrophy caused by cancer cachexia.

    abstract：:Cachexia, also known as wasting syndrome notably with skeletal muscle atrophy, costs nearly one-third of all cancer deaths in man. (-)-Epigallocatechin-3-gallate (EGCG), the principal polyphenolic component in green tea, is a potent preventive against cachexia as well as cancers. However, how EGCG counteracts cachexia...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2011.02.023

    authors： Wang H,Lai YJ,Chan YL,Li TL,Wu CJ

    更新日期：2011-06-01 00:00:00

  • CD100-plexin-B1 induces epithelial-mesenchymal transition of head and neck squamous cell carcinoma and promotes metastasis.

    abstract：:Head and neck squamous cell carcinoma (HNSCC) is one of the most lethal cancers mainly due to the high rate of metastasis. Here, we find that the expression level of CD100 in HNSCC is positively correlated with the T category, pathological grade and lymph node metastasis of the tumor. The level of soluble CD100 (sCD10...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2019.04.013

    authors： Zhang C,Qiao H,Guo W,Liu Y,Yang L,Liu Y,Jin B,Fu M,Wang G,Li W

    更新日期：2019-07-28 00:00:00