Abstract:
:Difluoro-phenyl-ethyl(4-aminopropylamidinohydrazone) (DFPA) was synthesized as an irreversible inhibitor of ornithine and S-adenosylmethionine decarboxylases and analyzed for antiproliferative effects on leukemia cells. The compound irreversibly inhibited ornithine and S-adenosylmethione decarboxylases. This inhibition could not be reversed by dialysis or chromatography on Sephadex G-50. When human lymphoid leukemia Molt 4B cells were cultured in the presence of the inhibitor, the intracellular levels of polyamines (putrescine, spermidine and spermine) and the rate of cell proliferation were markedly depressed. In these polyamine-depleted and growth-retarded cells, the synthesis of protein, but not of DNA or RNA, was observed to be significantly inhibited.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Hibasami H,Sakurai M,Maekawa S,Murata T,Nakashima Kdoi
10.1016/0304-3835(88)90096-1subject
Has Abstractpub_date
1988-03-01 00:00:00pages
121-7issue
2eissn
0304-3835issn
1872-7980pii
0304-3835(88)90096-1journal_volume
39pub_type
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