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DNA viruses in human cancer: an integrated overview on fundamental mechanisms of viral carcinogenesis.

Abstract：

:The first experimental data suggesting that neoplasm development in animals might be influenced by infectious agents were published in the early 1900s. However, conclusive evidence that DNA viruses play a role in the pathogenesis of some human cancers only emerged in the 1950s, when Epstein-Barr virus (EBV) was discovered within Burkitt lymphoma cells. Besides EBV, other DNA viruses consistently associated with human cancers are the hepatitis B virus (HBV), human papillomavirus (HPV), and Kaposi sarcoma herpesvirus (KSHV). Although each virus has unique features, it is becoming clearer that all these oncogenic agents target multiple cellular pathways to support malignant transformation and tumor development.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Elgui de Oliveira D

doi

10.1016/j.canlet.2006.05.010

subject

Has Abstract

pub_date

2007-03-18 00:00:00

pages

182-96

issue

2

eissn

0304-3835

issn

1872-7980

pii

S0304-3835(06)00387-9

journal_volume

247

pub_type

杂志文章,评审

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