Abstract:
:The mutagenic activities of N-nitrosobis(2-hydroxypropyl)amine (BHP) and its related compounds were studied in Salmonella typhimurium TA100 and TA98 strains by Ames's liquid incubation assay in the presence or absence of lung and liver S9 of rats treated with polychlorinated biphenyl (PCB). BHP and its related compounds, N-nitroso-(2-hydroxypropyl)(2-oxopropyl)amine (HPOP), N-nitrosobis(2-oxopropyl)amine (BOP), N-nitrosobis(2-acetoxypropyl)amine (BAP), and N-nitroso-2,6-dimethylmorpholine (NDMM) showed negative mutagenicity in the absence of lung and liver S9 in TA100 and TA98 strains while those compounds showed positive in the presence of liver S9 in TA100 strain. HPOP and BOP showed positive mutagenic activity in the presence of lung S9 in TA100 strain. HPOP showed the strongest mutagenic activity in the presence of lung and liver S9.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Mori Y,Niwa T,Takahashi H,Toyoshi K,Denda A,Takahashi S,Konishi Ydoi
10.1016/0304-3835(83)90235-5subject
Has Abstractpub_date
1983-04-01 00:00:00pages
271-5issue
3eissn
0304-3835issn
1872-7980pii
0304-3835(83)90235-5journal_volume
18pub_type
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