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Enhancement of tumorigenesis by N-nitrosodiethylamine, N-nitrosopyrrolidine and N6-(methylnitroso)-adenosine by ethanol.

Abstract：

:Inclusion of 10% ethanol with 6.8 ppm N-nitrosodiethylamine in the drinking water of strain A male mice resulted in a 4-fold enhancement of multiplicity of lung tumors and a 16-fold increase in incidence of fore-stomach tumors, compared with carcinogen alone. Given with 40 ppm N-nitrosopyrrolidine, ethanol caused a 5.5-fold increase in lung tumor multiplicity. The inclusion of 15% ethanol with N6-(methylnitroso)adenosine, given orally to Swiss female mice, led to reduced body weights and shortened survival time related to hemangiosarcoma occurrence or increased incidence of thymic lymphoma, depending on dose of carcinogen. The data provide additional support for the proposal that co-administered ethanol increases the tumorigenicity of nitrosamines by blocking hepatic first-pass clearance.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Anderson LM,Carter JP,Driver CL,Logsdon DL,Kovatch RM,Giner-Sorolla A

doi

10.1016/0304-3835(93)90220-4

subject

Has Abstract

pub_date

1993-01-15 00:00:00

pages

61-6

issue

1

eissn

0304-3835

issn

1872-7980

pii

0304-3835(93)90220-4

journal_volume

68

pub_type

杂志文章

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