Abstract:
:Up to a 50% rate of thyroid gland tumours was induced in Sprague-Dawley rats after s.c. administration of di-isopropanolnitrosamine (DIPN). The neoplasms occurred both unilaterally and bilaterally, and were identified histologically as adenomas and adenocarcinomas of follicular epithelium origin. In a few instances, adenomas were observed as early as 18 weeks after commencement of treatment. Most adenocarcinomas could be observed macroscopically, and frequently demonstrated infiltration into the surrounding muscles.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Reznik G,Mohr Udoi
10.1016/s0304-3835(77)80022-0subject
Has Abstractpub_date
1977-03-01 00:00:00pages
201-7issue
4-5eissn
0304-3835issn
1872-7980pii
S0304-3835(77)80022-0journal_volume
2pub_type
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