Abstract:
:Previous work by others shows that d-limonene (LIM) inhibits carcinogen-induced lung tumorigenesis in mice and strongly suggests that LIM can inhibit the metabolic activation of nitrosamines such as 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Thus, in the current study, the ability of LIM and other monoterpenes to inhibit the activation of the tobacco-specific NNK was examined in murine pulmonary and hepatic microsomes after addition in vitro or administration in vivo. LIM inhibited the metabolic activation of NNK in both pulmonary and hepatic microsomes. Perillyl alcohol was a more potent inhibitor than LIM, while p-menth-1-ene was equipotent with LIM. After administration of LIM, limonene 1,2-oxide, or perillyl alcohol in vivo, significant inhibition of cytochrome P450-mediated metabolites (NNK N-oxide and HPB) was found at 1 and 4 h after administration of monoterpene. These results indicate that LIM and other monoterpenes are effective inhibitors of NNK metabolic activation, and that other monoterpenes such as perillyl alcohol may be effective chemopreventive agents against NNK-induced lung tumorigenesis.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Morse MA,Toburen ALdoi
10.1016/0304-3835(96)04252-8subject
Has Abstractpub_date
1996-07-12 00:00:00pages
211-7issue
2eissn
0304-3835issn
1872-7980pii
0304383596042528journal_volume
104pub_type
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