Cancer stem cells in osteosarcoma.

Abstract:

:Osteosarcoma is the most common primary bone tumour in children and adolescents and advanced osteosarcoma patients with evidence of metastasis share a poor prognosis. Osteosarcoma frequently gains resistance to standard therapies highlighting the need for improved treatment regimens and identification of novel therapeutic targets. Cancer stem cells (CSC) represent a sub-type of tumour cells attributed to critical steps in cancer including tumour propagation, therapy resistance, recurrence and in some cases metastasis. Recent published work demonstrates evidence of cancer stem cell phenotypes in osteosarcoma with links to drug resistance and tumorigenesis. In this review we will discuss the commonly used isolation techniques for cancer stem cells in osteosarcoma as well as the identified biochemical and molecular markers.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Brown HK,Tellez-Gabriel M,Heymann D

doi

10.1016/j.canlet.2016.11.019

subject

Has Abstract

pub_date

2017-02-01 00:00:00

pages

189-195

eissn

0304-3835

issn

1872-7980

pii

S0304-3835(16)30707-8

journal_volume

386

pub_type

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