Abstract:
:Osteosarcoma is the most common primary bone tumour in children and adolescents and advanced osteosarcoma patients with evidence of metastasis share a poor prognosis. Osteosarcoma frequently gains resistance to standard therapies highlighting the need for improved treatment regimens and identification of novel therapeutic targets. Cancer stem cells (CSC) represent a sub-type of tumour cells attributed to critical steps in cancer including tumour propagation, therapy resistance, recurrence and in some cases metastasis. Recent published work demonstrates evidence of cancer stem cell phenotypes in osteosarcoma with links to drug resistance and tumorigenesis. In this review we will discuss the commonly used isolation techniques for cancer stem cells in osteosarcoma as well as the identified biochemical and molecular markers.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Brown HK,Tellez-Gabriel M,Heymann Ddoi
10.1016/j.canlet.2016.11.019subject
Has Abstractpub_date
2017-02-01 00:00:00pages
189-195eissn
0304-3835issn
1872-7980pii
S0304-3835(16)30707-8journal_volume
386pub_type
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