Abstract:
:Since calpain 6 is overexpressed in uterine cervical cancer tissue compared to normal tissue, we sought to define the role of calpain 6 during tumorigenesis. We overexpressed calpain 6 or inhibited calpain 6 in human cervical cancer cells (HeLa cells) and human umbilical vein endothelial cells (HUVECs), and measured cisplatin-mediated apoptosis and VEGF-mediated angiogenesis. The results indicated that calpain 6 supported tumorigenesis by inhibiting apoptosis and facilitating angiogenesis. To our knowledge, this result is the first evidence implicating calpain 6 in tumorigenesis, and it reveals calpain 6 as a novel therapeutic target for certain types of cancers.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Rho SB,Byun HJ,Park SY,Chun Tdoi
10.1016/j.canlet.2008.06.020subject
Has Abstractpub_date
2008-11-28 00:00:00pages
306-13issue
2eissn
0304-3835issn
1872-7980pii
S0304-3835(08)00500-4journal_volume
271pub_type
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