Abstract:
:Eighty samples of cervical invasive squamous cell carcinoma were examined for ras gene mutations using polymerase chain reaction (PCR) followed by restriction enzyme digestion. We found 28 (35%) cervical cancers contained ras mutations at H-ras codon 12, 49 (61%) at K-ras codon 12, and 5 (6%) at K-ras codon 13. There were no significant differences in incidence of the ras gene mutations among different histologic grades or clinical stages of the cancer (P > 0.05). This result suggests that ras mutation may be an important step involved in a substantial number of cervical carcinoma. The interaction of ras with other genes and/or events may also be involved in pathogenesis of this malignancy.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Wong YF,Chung TK,Cheung TH,Lam SK,Xu YG,Chang AMdoi
10.1016/0304-3835(95)03857-ssubject
Has Abstractpub_date
1995-08-16 00:00:00pages
29-32issue
1-2eissn
0304-3835issn
1872-7980pii
0304-3835(95)03857-Sjournal_volume
95pub_type
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