Effect of osteoblast supernatants on cancer cell migration and invasion.

abstract：:Neoxanthin and fucoxanthin, which have the characteristic structure of 5,6-monoepoxide and an allenic bond, were previously found to reduce the viability of human prostate cancer cells most intensively among 15 dietary carotenoids tested. In the present study, the induction of apoptosis in PC-3 cells by these two caro...

journal_title：Cancer letters

authors： Kotake-Nara E,Asai A,Nagao A

更新日期：2005-03-18 00:00:00

abstract：:Monocrotaline is a representative naturally occurring genotoxic pyrrolizidine alkaloid. Metabolism of monocrotaline by liver microsomes of F344 female rats generated (+/-)6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine (DHP) and monocrotaline-N-oxide as major metabolites. Metabolism in the presence of triacetylea...

journal_title：Cancer letters

authors： Wang YP,Yan J,Beger RD,Fu PP,Chou MW

更新日期：2005-08-08 00:00:00

abstract：:Two human prostate tumor cell lines which exhibit a 2.4-fold difference in sensitivity to cis-platinum (cis-Pt) were found to possess slightly different sulphydryl contents, and the presence of a metallothionein-like zinc-binding protein was demonstrated in the line exhibiting relative resistance to cis-Pt. Although t...

journal_title：Cancer letters

authors： Metcalfe SA,Cain K,Hill BT

更新日期：1986-05-01 00:00:00

abstract：:Amplification and overexpression of PPM1D (protein phosphatase magnesium-dependent 1 delta) has been observed in various cancer cell lines and primary tumors and has also been associated with cancers of poor prognosis. In addition to the negative feedback regulation of p38-p53 signaling, PPM1D inhibits other tumor sup...

journal_title：Cancer letters

authors： Pärssinen J,Alarmo EL,Khan S,Karhu R,Vihinen M,Kallioniemi A

更新日期：2008-01-18 00:00:00

abstract：:We evaluated the association between the XPD exon 10 Asp(312)Asn and exon 23 Lys(751)Gln polymorphisms and the risk of pancreatic cancer in a hospital-based study of 344 patients and 386 controls frequency matched by age, gender, and race. Stratified analyses showed ever smokers carrying the Asn(312)Asn genotype had a...

journal_title：Cancer letters

authors： Jiao L,Hassan MM,Bondy ML,Abbruzzese JL,Evans DB,Li D

更新日期：2007-01-08 00:00:00

abstract：:Populations consuming soybeans have reduced rates of breast, colon and prostate cancer possibly due, in part, to the presence in soybeans of two estrogenic isoflavones, genistein and daidzein. This study investigated the genotoxicity of these soya isoflavones and their interactions with 7,12-dimethylbenz[a]anthracene ...

journal_title：Cancer letters

authors： Giri AK,Lu LJ

更新日期：1995-08-16 00:00:00

abstract：:Though significant progress has been made in the availability of diagnostic techniques and treatment strategies, pancreatic cancer remains a disease of high mortality rates. Therefore, there is an urgent need for a better understanding of the molecular mechanisms that governs the oncogenesis and metastasis process of ...

journal_title：Cancer letters

authors： Liang C,Qin Y,Zhang B,Ji S,Shi S,Xu W,Liu J,Xiang J,Liang D,Hu Q,Ni Q,Yu X,Xu J

更新日期：2017-03-01 00:00:00

abstract：:We used selective biochemical markers of effect to evaluate some non-genotoxic cocarcinogenic properties of methyl thiophanate (MTH) associated with cytochrome P450 (CYP) changes. Several CYP-dependent reactions were monitored in the liver, kidney and lung microsomes of male and female Sprague-Dawley rats treated (i.p...

journal_title：Cancer letters

authors： Paolini M,Pozzetti L,Perocco P,Mazzullo M,Cantelli-Forti G

更新日期：1999-01-29 00:00:00

abstract：:In previous National Toxicology Program (NTP) studies, rotenone reduced the background incidence of hepatocellular carcinoma in male B6C3F1 mice. In the present studies, rotenone reduced the basal hepatic labeling index of male B6C3F1 mice in a dose-dependent fashion and inhibited hepatocellular proliferation, but not...

journal_title：Cancer letters

authors： Cunningham ML,Soliman MS,Badr MZ,Matthews HB

更新日期：1995-08-16 00:00:00

abstract：:A hitherto unreported lactate dehydrogenase (LD) isoenzyme, which migrates electrophoretically to the relative position between LD2 and LD3 has been identified in the electropheratogram in 7 of 7 (100%) cultured hepatoma cell lines with various degrees of differentiation and is thus given the name LD2-3. LD2-3 seems t...

journal_title：Cancer letters

authors： Liu TZ,Chen PY,Chiu DT,Wei JS,Chang KS,Lin KH

更新日期：1994-12-09 00:00:00

abstract：:Intussusception is an alternative to the sprouting mode of angiogenesis. The advantage of this mechanism of vascular growth is that blood vessels are generated more rapidly and the capillaries thereby formed are less leaky. This review article summarizes our current knowledge concerning the role played by intussuscept...

journal_title：Cancer letters

authors： Ribatti D,Djonov V

更新日期：2012-03-28 00:00:00

abstract：:The dose-dependence of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) carcinogenicity when given in the diet continuously throughout the experiment (56 weeks) at doses of 100, 200 and 400 ppm, was examined in F344 male rats. Tumors developed dose-dependently in the liver, Zymbal glands and skin in the experimen...

journal_title：Cancer letters

authors： Kushida H,Wakabayashi K,Sato H,Katami M,Kurosaka R,Nagao M

更新日期：1994-08-15 00:00:00

abstract：:Ursodeoxycholic acid (UDCA) and its derivatives were examined for anti-angiogenic activities by using the chick embryo chorioallantoic membrane (CAM) assay. The presence of UDCA or its derivatives inhibited angiogenesis in a dose-dependent manner; the dose required for half-maximal inhibition (ID50) was 4 microg per C...

journal_title：Cancer letters

authors： Suh H,Jung EJ,Kim TH,Lee HY,Park YH,Kim KW

更新日期：1997-02-26 00:00:00

abstract：:Glucose and glutamine metabolism of two microregions of human infiltrating ductile breast cancer, the center and the periphery, was studied and the results were compared with those of healthy mammary glands. In general, the activities of glycolytic enzymes and of phosphate-dependent glutaminase were as follows: center...

journal_title：Cancer letters

authors： dos Santos MA,Borges JB,de Almeida DC,Curi R

更新日期：2004-12-28 00:00:00

abstract：:Cancer cells are derived from their precursor cells, which normally develop to the matured cells to form individual organs. Neuroblastoma, one of the most common pediatric solid tumors, originates from possible cancer stem cells derived from the neural crest. During the development, neural crest cells segregate into s...

journal_title：Cancer letters

authors： Nakagawara A,Ohira M

更新日期：2004-02-20 00:00:00

abstract：:In this study, we demonstrated that thrombin activates protein kinase C (PKC), mitogen activated protein kinases (MAP kinases), transcription factor nuclear factor-kappa B (NF-kappa B), and cAMP-dependent protein kinase (PKA) in the human renal carcinoma cell line A-498. In addition, it enhanced the migratory capacity...

journal_title：Cancer letters

authors： Kaufmann R,Junker U,Junker K,Nuske K,Ranke C,Zieger M,Scheele J

更新日期：2002-06-28 00:00:00

abstract：:The mammary carcinogenicity of two diol epoxide metabolites of the commonly occurring environmental carcinogen benzo[j]fluoranthene (BjF) was investigated by direct application to the tissue beneath the mammary glands of female CD rats. The compounds tested were trans-4,5-dihydroxy-anti-6,6a.epoxy-4,5,6,6a-tetrahydroB...

journal_title：Cancer letters

authors： Hecht SS,Rivenson A,Amin S,Krzeminski J,el-Bayoumy K,Reddy BS,Kurtzke C,La Voie EJ

更新日期：1996-09-10 00:00:00

abstract：:We examined the effect of alcohol consumption, cigarette smoking and flushing response on esophageal squamous cell carcinoma (ESCC) in a large-scale population-based cohort study. 44,970 middle-aged and older Japanese men were followed. A total of 215 cases of ESCC were newly diagnosed. Alcohol consumption and cigaret...

journal_title：Cancer letters

authors： Ishiguro S,Sasazuki S,Inoue M,Kurahashi N,Iwasaki M,Tsugane S,JPHC Study Group.

更新日期：2009-03-18 00:00:00

abstract：:The mesenchymal (MES) subtype of glioblastoma (GBM) indicated a more malignant phenotype and worse prognosis compared with their proneural (PN) counterpart. The plasticity between PN and MES transcriptome signatures provided an approach for clinical intervention. However, few miRNAs have been identified to participate...

journal_title：Cancer letters

authors： Yang F,Liu X,Liu Y,Liu Y,Zhang C,Wang Z,Jiang T,Wang Y

更新日期：2017-06-28 00:00:00

abstract：:Carcinogenicity of quercetin and rutin were examined in inbred ACI strain rats. Rats were given a diet containing 1% or 5% quercetin or 5% rutin for 540 days, or 10% quercetin and 10% rutin for 850 days. Rats in control groups were fed a normal basal diet. Most tumors found in experimental groups were also found in th...

journal_title：Cancer letters

authors： Hirono I,Ueno I,Hosaka S,Takanashi H,Matsushima T,Sugimura T,Natori S

更新日期：1981-06-01 00:00:00

abstract：:Much of the interest on the chemopreventive properties of licorice has been focused on the plant genius Glycyrrhiza glabra. In this study the ethanol extract of Chinese licorice root, Glycyrrhiza uralensis (G. uralensis) was investigated for its estrogenic effect and the ability to inhibit cell proliferation in the MC...

journal_title：Cancer letters

authors： Jo EH,Kim SH,Ra JC,Kim SR,Cho SD,Jung JW,Yang SR,Park JS,Hwang JW,Aruoma OI,Kim TY,Lee YS,Kang KS

更新日期：2005-12-18 00:00:00

abstract：:Efficient DNA repair mechanisms comprise a critical component in the protection against human cancer, as indicated by the high predisposition to cancer of individuals with germ-line mutations in DNA repair genes. This includes biallelic germ-line mutations in the MUTYH gene, encoding a DNA glycosylase that is involved...

journal_title：Cancer letters

authors： Paz-Elizur T,Sevilya Z,Leitner-Dagan Y,Elinger D,Roisman LC,Livneh Z

更新日期：2008-07-18 00:00:00

abstract：:There is an urgent need to elucidate the mechanistic links between obesity and colon cancer. Convincing evidence for the role of Lgr5(+) stem cells in colon tumorigenesis has been established; however, the influence of obesity on stem cell maintenance is unknown. We assessed the effects of high fat (HF) feeding on col...

journal_title：Cancer letters

authors： DeClercq V,McMurray DN,Chapkin RS

更新日期：2015-12-28 00:00:00

abstract：:The effects of caloric restriction on the incidence of mammary tumor development, the levels of the expression of mouse mammary tumor virus (MMTV)- and prolactin-RNA, as well as the levels of serum prolactin, were investigated in virgin RIII/Sa mice, a strain known to display a high incidence of spontaneous mammary tu...

journal_title：Cancer letters

authors： Li HW,Zhao W,Sarkar NH

更新日期：1994-05-16 00:00:00

abstract：:Autophagy is a membrane process that results in the transporting of cellular contents to lysosomes for degradation. Autophagic cell death is another way of programed cell death called type II PCD, which has complicated connection with apoptosis, both of these two types of cell death play an important role in tumor dev...

journal_title：Cancer letters

authors： Xiong HY,Guo XL,Bu XX,Zhang SS,Ma NN,Song JR,Hu F,Tao SF,Sun K,Li R,Wu MC,Wei LX

更新日期：2010-02-01 00:00:00

abstract：:Membrane glycoprotein synthesis was studied in non-tumorigenic and tumor cells treated with the lymphokine hormone, lymphotoxin, to define the biochemical mechanisms by which lymphotoxin prevents carcinogenesis and inhibits growth of tumor cells. Syrian hamster lymphotoxin increased the synthesis of high molecular wei...

journal_title：Cancer letters

authors： Fuhrer JP,Evans CH

更新日期：1983-07-01 00:00:00

abstract：:The stem cell-like characteristics of tumor cells are not only essential for tumor development and malignant progression, but also significantly contribute to therapy resistance. However, it remains poorly understood how cancer cell differentiation or stemness is regulated in vivo. We investigated the role of the stem...

journal_title：Cancer letters

authors： Begum A,Kim Y,Lin Q,Yun Z

更新日期：2012-05-01 00:00:00

abstract：:Modifying effects of 5-hydroxy-4-(2-phenyl-(E)-ethenyl)-2(5H)-furanone, a novel synthesized retinoid (KYN-54), on intestinal carcinogenesis were examined in a rat model using azoxymethane (AOM). A total of ninety male F344 rats, 6 weeks old, were divided into 4 groups. Group 1 (20 rats) was fed a diet containing KYN-5...

journal_title：Cancer letters

authors： Mori H,Yoshimi N,Sugie S,Tanaka T,Morishita Y,Jinlong G,Tamai Y,Torihara M,Yamahara J

更新日期：1992-09-30 00:00:00

abstract：:The role of mesothelial cells in the intraperitoneal spread of ovarian cancer is still elusive. In particular, it is unclear whether these cells constitute a passive barrier preventing cancer cell progression or perhaps act as an active promoter of this process. In this report we show that omental human peritoneal mes...

journal_title：Cancer letters

authors： Mikuła-Pietrasik J,Sosińska P,Kucińska M,Murias M,Maksin K,Malińska A,Ziółkowska A,Piotrowska H,Woźniak A,Książek K

更新日期：2014-12-28 00:00:00

abstract：:Cancer cells often exhibit altered epigenetic signatures that can misregulate genes involved in processes such as transcription, proliferation, apoptosis and DNA repair. As regulation of chromatin structure is crucial for DNA repair processes, and both DNA repair and epigenetic controls are deregulated in many cancers...

journal_title：Cancer letters

authors： Agarwal P,Jackson SP

更新日期：2016-10-01 00:00:00