Abstract:
:Intussusception is an alternative to the sprouting mode of angiogenesis. The advantage of this mechanism of vascular growth is that blood vessels are generated more rapidly and the capillaries thereby formed are less leaky. This review article summarizes our current knowledge concerning the role played by intussusceptive microvascular growth in tumor growth. Interestingly, an angiogenic switch from sprouting to intussusceptive angiogenesis occurs after treatment with angiogenesis inhibitors and may be considered as a tumor-protective adaptative response.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Ribatti D,Djonov Vdoi
10.1016/j.canlet.2011.10.040subject
Has Abstractpub_date
2012-03-28 00:00:00pages
126-31issue
2eissn
0304-3835issn
1872-7980pii
S0304-3835(11)00657-4journal_volume
316pub_type
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