Abstract:
:A hitherto unreported lactate dehydrogenase (LD) isoenzyme, which migrates electrophoretically to the relative position between LD2 and LD3 has been identified in the electropheratogram in 7 of 7 (100%) cultured hepatoma cell lines with various degrees of differentiation and is thus given the name LD2-3. LD2-3 seems to be specific for hepatoma cells because this atypical isoenzyme can not be detected in other tumor cell lines. In addition, the hepatoma cell lines also show a distinct pattern of LD isoenzyme and the isoenzyme pattern varies with the degree of differentiation. Hence, the expression pattern of LD isoenzyme phenotypes may provide a good marker for the investigation of human hepatoma cell differentiation.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Liu TZ,Chen PY,Chiu DT,Wei JS,Chang KS,Lin KHdoi
10.1016/0304-3835(94)90222-4subject
Has Abstractpub_date
1994-12-09 00:00:00pages
193-8issue
2eissn
0304-3835issn
1872-7980pii
0304-3835(94)90222-4journal_volume
87pub_type
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