Abstract：
:Monocrotaline is a representative naturally occurring genotoxic pyrrolizidine alkaloid. Metabolism of monocrotaline by liver microsomes of F344 female rats generated (+/-)6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine (DHP) and monocrotaline-N-oxide as major metabolites. Metabolism in the presence of triacetyleandomycin, a P450 3A enzyme inhibitor, reduced the formation of DHP by 52% and monocrotaline N-oxide formation by 59%. Dexamethasone significantly induced microsomal monocrotaline metabolizing enzyme activities in rat liver and lung. Previously, we have identified a set of DHP-derived DNA adducts from DHP-modified calf thymus DNA by (32)P-post labeling/HPLC analysis. Metabolism of monocrotaline in the presence of calf thymus DNA resulted in a similar set of DHP-DNA adducts. These DHP-DNA adducts were also found in the liver DNA of rats treated with monocrotaline. The time course of the DHP-derived DNA adduct formation and removal in the liver of rats gavaged with a single dose (10mg/kg) of monocrotaline was similar to that of rats treated with riddelliine. The levels of DHP-DNA adducts in liver DNA of rats treated with monocrotaline were much lower than that of riddelliine-treated rats. Results from this study indicate that (i) DHP is a common reactive metabolite for retronecine-type of pyrrolizidine alkaloids, (ii) the formation of DHP-derived DNA adducts in the liver DNA of rats treated with monocrotaline suggests that monocrotaline-induced tumorigenicity is through a genotoxic mechanism.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Wang YP,Yan J,Beger RD,Fu PP,Chou MWdoi
10.1016/j.canlet.2004.11.039keywords:
subject
Has Abstractpub_date
2005-08-08 00:00:00pages
27-35issue
1eissn
0304-3835issn
1872-7980pii
S0304-3835(04)00933-4journal_volume
226pub_type
杂志文章相关文献
CANCER LETTERS文献大全abstract：:Malignant tumor cells of different origin seem to have preferential sites for metastasis. Breast cancer, prostate cancer and certain melanomas have bone as one of their preferential targets for metastasis. Bone is continuously being remodelled, a process largely controlled by local growth factors. A possible explanati...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(95)03955-v
更新日期：1995-10-20 00:00:00
abstract：AIM:To estimate the incidence and latency of Vaginal Intraepithelial Neoplasia (VAIN) in women previously hysterectomized for benign/malign pathology and to evaluate the role of high risk HPVs in the prediction of persistent or recurrent disease. SUBJECTS AND METHODS:830 women with prior hysterectomy for benign/malign...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2006.09.003
更新日期：2007-05-08 00:00:00
abstract：:Epidermal growth factor receptor (EGFR) is highly expressed in many human tumors including hepatocellular carcinoma (HCC). Therefore, inhibition of EGF receptors could be a potential target for anticancer therapy. In this study, we investigated the effects of two EGFR tyrosine kinase inhibitors, PD153035 and its analo...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2006.05.018
更新日期：2007-04-08 00:00:00
abstract：:The mitochondrial genetic system is indispensable for the biosynthesis of the enzyme complexes involved in aerobic energy generation. Tetracyclines inhibit the expression of only the mitochondrial genes because they specifically block mitochondrial protein synthesis. A salient feature is that this inhibition occurs at...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(84)80023-3
更新日期：1984-11-01 00:00:00
abstract：:Spectroscopic techniques have demonstrated that in the microscopically normal mucosa, there is an increase in mucosal micro-circulation in patients harboring neoplasia elsewhere in the colon (i.e. marker of field carcinogenesis). However, the physiological and molecular basis of this early increase in blood supply (EI...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2011.03.008
更新日期：2011-07-28 00:00:00
abstract：:N-ethyl-N-nitrosourea-induced rat gliomas showed a stimulation of cytosolic spermidine N-acetyltransferase activity compared with normal brain, with an increased formation of N1 and N8-acetylspermidine, suggesting the activation of two enzymes acetylating the polyamine in N1 and N8 position, respectively. The enhancem...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(94)90387-5
更新日期：1994-01-30 00:00:00
abstract：:We investigated the role of the 5-lipoxygenase (5-LOX) pathway of arachidonic acid metabolism in tumour necrosis factor-alpha (TNF-alpha)-induced differentiation of human leukemic HL-60 cells using MK-886, an inhibitor of 5-LOX activating protein. MK-886 augmented cell cycle arrest and differentiation induced by TNF-a...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2005.06.012
更新日期：2006-06-18 00:00:00
abstract：:Microarray analysis is a powerful technology, but its impact on routine diagnosis for the near future maybe in revealing individual genes, which are useful diagnostic markers. Recently microarray analysis has identified a novel subgroup of childhood precursor-B acute lymphoblastic leukaemia (ALL) from a unique gene ex...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2005.11.012
更新日期：2006-10-28 00:00:00
abstract：:In this study we demonstrate the involvement of ras oncogenes in bladder cancer at the level of RNA overexpression. We examined 26 bladder specimens, consisting of paired tumor and adjacent normal tissue and found that H-ras transcripts were overexpressed in 39% of the specimens while K-ras and N-ras in 58% of total s...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(96)04372-8
更新日期：1996-10-22 00:00:00
abstract：:Gastric cancers with and those without high-frequency microsatellite instability (MSI-H) represent distinctive pathways of carcinogenesis. The aim of this study was to clarify if expression of p53 related genes involved in angiogenesis is differentially regulated between these cancers. We systematically analyzed the e...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2007.02.004
更新日期：2007-08-28 00:00:00
abstract：:Aberrant activation of mammalian target of rapamycin complex 1 (mTORC1), caused by loss or inactivation of TSC1/TSC2 protein complex, leads to negative feedback inhibition of Akt. The exact mechanisms of this process are still not fully understood. Here we present evidence for the involvement of STAT3, a known mTORC1 ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2011.09.006
更新日期：2011-12-27 00:00:00
abstract：:One of the most promising substances used in photodynamic therapy (PDT) is 5-aminolevulinic acid (ALA), which induces endogenous synthesis and accumulation of porphyrins in malignant cells. In this paper we have shown that both topical and intratumoral administration of ALA in a subcutaneously implanted mammary carcin...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(99)00079-8
更新日期：1999-07-01 00:00:00
abstract：:Matrix Gla protein (MGP) is a vitamin K-dependent extracellular matrix protein commonly found in a variety of tissues. In this study, we describe the potential use of MGP gene expression as the tumor marker of colorectal cancer. A decrease in expression of the MGP gene was also discovered in colorectal cancer using di...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(01)00416-5
更新日期：2001-04-10 00:00:00
abstract：:We carried out a mutational analysis of BRCA1 and BRCA2 genes in 103 individuals from a population in Western Central Spain and we identified nine new variants: two truncating mutations in BRCA2 [2604C>A (Y792X), 8873del4], three missense mutations in BRCA2 [677A>G (H150R), 958G>A (D224N) and 3398A>G (K1057R], and fou...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2005.03.006
更新日期：2006-02-20 00:00:00
abstract：:Telomeres constitute the ends of the linear eukaryotic chromosomes and are essential for the maintenance of chromosome stability and genome integrity. One of the consequences of an altered telomere structure is the formation of telomeric fusions (TFs), that is aberrant chromosomes in which two elements are fused at th...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2003.08.028
更新日期：2004-01-08 00:00:00
abstract：:DDX1, a gene mapping to the 2p24 region, has been observed to be co-amplified with MYCN in neuroblastoma. Co-amplification of the DDX1 gene is a consequence of the short physical distance between the two genes. Recently, it has been found that neuroblastoma cells can show a low increase in MYCN gene copy number, defin...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2007.05.010
更新日期：2007-10-18 00:00:00
abstract：:Tumor-derived exosomes (TEXs) contain enriched miRNAs that act as novel non-invasive biomarkers for cancer diagnosis and play a role in cancer progression. We investigated the exosomal miRNAs that affect cancer progression in non-small cell lung cancer (NSCLC) and identified the specific molecules involved. We identif...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2020.01.023
更新日期：2020-04-10 00:00:00
abstract：:The p53 signaling pathway plays critical roles in determining the radio-sensitivity of normal tissues but is frequently inactivated in cancer. In various cancer cells, p53 has different effects on radio-sensitivity through complex mechanisms. Acetylation of p53 is an important means of post-translational modifications...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2015.04.015
更新日期：2015-07-28 00:00:00
abstract：:Isothiocyanates are found in cruciferous vegetables such as broccoli, Brussels sprouts, cauliflower, and cabbage. Epidemiologic studies suggest that cruciferous vegetable intake may lower overall cancer risk, including colon and prostate cancer. Sulforaphane (SFN) is an isothiocyanate found in cruciferous vegetables a...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2008.04.018
更新日期：2008-10-08 00:00:00
abstract：:Recent studies indicate that gossypol possesses potent antitumor activities in vitro and in vivo. The nuclear factor-kappa B (NF-kappaB) plays an important role in tumor cell growth, proliferation, invasion, and survival. In this study, we investigated the effects and the molecular mechanisms of gossypol on NF-kappaB ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2008.01.030
更新日期：2008-06-18 00:00:00
abstract：:Formation of DNA-adducts by 3-BHA or its metabolites, i.e., tert-butyl-1,4-benzoquinone (TBQ) and 5-methoxy-3-tert-butyl-1,2-benzoquinone (3-TBOQ), as well as DNA-adduct formation by 4-nitroquinoline-N-oxide (4NQO), in rat forestomach were examined by an enzymatic 32P-postlabeling assay. Four DNA-adducts were clearly ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(89)90117-1
更新日期：1989-12-01 00:00:00
abstract：:Naturally occurring fecal mutagens, called fecapentaenes, are hypothesized to contribute to large bowel carcinogenesis. To understand health risks it is necessary to relate fecal mutagen concentrations to intestinal pathologies, i.e. colon cancer. However, fast and reliable methods for analysis of stool for fecapentae...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(89)90104-3
更新日期：1989-01-01 00:00:00
abstract：:The phenomenon of cellular dormancy has been observed in normal adult stem cells in many different tissues such as the skin, the intestine and the hematopoietic system. These dormant cells have been proposed to be important for life-long self-renewal and for the generation of the different cellular lineages. As tumor ...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2013.04.019
更新日期：2013-11-28 00:00:00
abstract：:Overexpression of Myristoylated Alanine-Rich C Kinase Substrate (MARCKS) is implicated in drug resistance and progression of multiple myeloma (MM). The basis for MARCKS induction and impact on MM are not known. Here we show that microRNA-34a (miR-34a), regulates MARCKS translation and is under-expressed in drug-resist...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2020.03.020
更新日期：2020-06-28 00:00:00
abstract：:Cancer metabolism has been extensively investigated by various tools, and the fact of diverse metabolic reprogramming in cancer cells has been gradually unveiled. In this review, we discuss some contributions in cancer metabolism by general proteomic analysis and post-translational modification analysis using mass spe...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2013.11.003
更新日期：2015-01-28 00:00:00
abstract：:Helicobacter pylori infection is the most important risk factor in the development of non-cardia gastric adenocarcinoma; host genetic variability and dietary co-factors also modulate risk. Because most H. pylori infections do not cause cancer, H. pylori heterogeneity has been investigated to identify possible virulenc...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2008.11.016
更新日期：2009-09-08 00:00:00
abstract：:A growing body of experimental evidence supports the view that certain human chromosomal fragile sites have roles to play in cancer. The principle lines of evidence are at the level of mutation mechanism and gene function. Most research in this area has previously focussed on the FRA3B common fragile site and the FHIT...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2005.07.041
更新日期：2006-01-28 00:00:00
abstract：:Gastrin, cholecystokinin2 receptor (CCK2R), and cyclooxygenase-2 (COX-2) have been implicated in the carcinogenesis and progression of gastric cancer. Our study demonstrated that antagonist or siRNA against CCK2R blocked amidated gastrin (G17)-induced activation of STAT3 and Akt in gastric cancer cell lines. G17-incre...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2012.12.030
更新日期：2013-05-10 00:00:00
abstract：:The expression of DNA-topoisomerase II was analysed at the protein level in newly diagnosed cases of acute lymphoblastic leukemia (ALL) in children. Blast cells obtained from 81 children with untreated ALL were determined by means of immunocytochemistry. Of the ALL, 49 (60%) were positive for topoisomerase II and 32 (...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(94)90368-9
更新日期：1994-09-15 00:00:00
abstract：:Heat shock protein 90 (HSP90) is a highly conserved molecular chaperone that facilitates the maturation of a wide range of proteins, and it has been recognized as a crucial facilitator of oncogene addiction and cancer cell survival. Although HSP90 function is regulated by a variety of post-translational modifications,...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2014.05.014
更新日期：2014-08-28 00:00:00
