Abstract：
:N-ethyl-N-nitrosourea-induced rat gliomas showed a stimulation of cytosolic spermidine N-acetyltransferase activity compared with normal brain, with an increased formation of N1 and N8-acetylspermidine, suggesting the activation of two enzymes acetylating the polyamine in N1 and N8 position, respectively. The enhancement in cytosolic spermidine N1-acetyltransferase was probably responsible for an activation of the polyamine interconversion pathway in gliomas, as indicated by an accumulation of N1-acetylspermidine and a marked increase in putrescine. Spermidine N8-acetyltransferase, although acetylating histones at a high rate, seemed distinct from the nuclear enzyme, as, unlike from the latter, it showed very low affinity for putrescine and was not inhibited by methylglyoxal bis(guanylhydrazone).
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Sessa A,Broglia E,Terreni MR,Perin Adoi
10.1016/0304-3835(94)90387-5subject
Has Abstractpub_date
1994-01-30 00:00:00pages
121-5issue
2-3eissn
0304-3835issn
1872-7980pii
0304-3835(94)90387-5journal_volume
76pub_type
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