Abstract:
:A polymorphism in the signal sequence (Ala-9Val) of the gene encoding the free radical-quenching manganese superoxide dismutase (MnSOD) has been reported to alter the risk for breast cancer. We evaluated this relationship in a population-based case-control study (476 breast cancer cases and 502 controls). Overall, relative risks were not significantly elevated in women with one (RR: 1.27; 95% CI: 0.91-1.77) or two (RR: 1.18; 95% CI: 0.81-1.73) Ala alleles compared to those homozygous for the wild-type Val genotype. Results do not support any overall association of the Ala-9Val MnSOD polymorphism to the development of breast cancer.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Egan KM,Thompson PA,Titus-Ernstoff L,Moore JH,Ambrosone CBdoi
10.1016/s0304-3835(03)00349-5keywords:
subject
Has Abstractpub_date
2003-09-10 00:00:00pages
27-33issue
1eissn
0304-3835issn
1872-7980pii
S0304383503003495journal_volume
199pub_type
杂志文章,多中心研究相关文献
CANCER LETTERS文献大全abstract::Several classes of plant polyphenols namely, flavonoids, chalcones and coumarins exhibited varying degrees of inhibition on the cell proliferation of human colon adenocarcinoma cell line 220.1. At the highest concentration tested (100 microM), many of the chalcones showed > 100% growth inhibition and their order of po...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(94)90147-3
更新日期:1994-07-15 00:00:00
abstract::The growth of primary subcutaneous fibrosarcomas and their pulmonary metastases was studied in normal and athymic Swiss mice. The metastases tended to develop more rapidly than did the primary tumors. However, when growth rates of tumors of small volumes (up to 1 cm3) were compared, the tumor and metastases exhibited ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(82)90129-x
更新日期:1982-03-01 00:00:00
abstract::Oral treatment with reduced glutathione for 10 weeks has no effect on the development of tumours from aflatoxin B1-induced gamma-glutamyl transpeptidase-positive pre-neoplastic focal lesions. ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(83)90086-1
更新日期:1983-11-01 00:00:00
abstract::Immunohistochemically detected expression of sialyl Lewis(x) (Le(x)) antigen was analyzed in 101 stage 0-II gastric cancers to clarify its prognostic value after curative gastrectomy. Patients with a high-expression of sialyl Le(x) antigen within their tumors had shorter disease-specific intervals than those with nega...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(01)00705-4
更新日期:2002-01-25 00:00:00
abstract::We constructed an SV40-derived expression vector containing a mutated albumin minigene of Nagase analbuminemic rats (NAR), and introduced it into cultured cells. Transient expression of the minigene mRNA was determined by RT-PCR. Three kinds of aberrant mRNAs were expressed by the non-hepatic cells COS-1, and the undi...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(94)90323-9
更新日期:1994-08-15 00:00:00
abstract::Associations between lung cancer risk and common polymorphisms in the DNA repair genes xeroderma pigmentosum complementation group D (XPD), X-ray repair cross-complementing group 1 (XRCC1), XRCC3 and apurinic/apyrimidinic endonuclease/redox factor 1 were examined within a randomized clinical trial designed to determin...
journal_title:Cancer letters
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0304-3835(02)00638-9
更新日期:2003-03-10 00:00:00
abstract::Insertion of functional interleukin-2 (IL-2) gene into a plasmacytoma cell line X63-Ag8.653 substantially reduced tumorigenicity of the resulting cloned cells, designated as X63-m-IL-2. Peritumoral administration of the X63-m-IL-2 cells, producing constitutively large quantities of IL-2, resulted in regressions of est...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(92)90104-4
更新日期:1992-03-15 00:00:00
abstract::Immunogenic, methylcholanthrene-induced sarcomas failed to elicit the production of rapidly cytolytic T lymphocytes in syngeneic mice, although they did elicit the production of more slowly cytotoxic cells. They were, however, susceptible to attack by cytolytic T cells from allo-immune mice and, if infected with ectro...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(78)80046-9
更新日期:1978-08-01 00:00:00
abstract::RNA interference (RNAi), a natural cellular mechanism for RNA-guided regulation of gene expression could in fact become new therapeutic modality if an appropriate efficient delivery strategy that is also reproducible and safe will be developed. Numerous efforts have been made for the past eight years to address this c...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2012.08.024
更新日期:2013-07-01 00:00:00
abstract::Multi-drug resistance (MDR) has become the largest obstacle to the success of cancer chemotherapies. The mechanisms of MDR and the approaches to test MDR have been discovered, yet not fully understood. This review covers the in vivo and in vitro approaches for the detection of MDR in the laboratory and the mechanisms ...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2014.03.013
更新日期:2014-06-01 00:00:00
abstract::The analogs of benzidine were assay for mutagenicity using Salmonella typhimurium TA-98 and TA-100 and a mouse liver enzyme preparation. Only 4-aminobiphenyl produced both frameshift and base pair substitution mutations and 3,3'-dichlorobenzidine was the only compound which was mutagenic without the mammalian enzyme f...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(78)93137-3
更新日期:1978-01-01 00:00:00
abstract::Methylation of liver and nasal mucosal DNA at the O6 position of guanine (O6-MeG) was measured in intact and castrated male rats after a dose of N-nitrosobis(2-oxopropyl)amine (BOP) (20 mg/kg; i.p.). There were no differences in O6-MeG persistence in liver DNA from either group. In the nasal mucosa more O6-MeG was det...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(90)90008-l
更新日期:1990-08-01 00:00:00
abstract::We have examined the effect of protease inhibitors on radiation-induced DNA amplification in vitro using an SV40-transformed Chinese hamster embryo cell line. DNA from cells irradiated with X-rays (10 Gy) or ultraviolet radiation (8 J/m2) resulted in an 8-fold or greater amplification of SV40 sequences compared with u...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(91)90083-t
更新日期:1991-02-01 00:00:00
abstract::The effect of magnesium hydroxide on the epithelial proliferation of the large bowel was examined using rats given methylazoxymethanol (MAM) acetate. Dietary administration of magnesium hydroxide at 250, 500, 1000 or 2000 ppm. for 1, 3 or 5 weeks did not influence the cell cycle of the cryptal cells of the large bowel...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(92)90196-3
更新日期:1992-02-14 00:00:00
abstract::The quality and frequency of mutations in PTEN gene were assessed in 59 carcinomas and 6 hyperplasias of the endometrium in women. Screening for mutations was done in all exons of PTEN gene by the PCR-SSCP analysis and DNA sequencing. Results were correlated with histological status and clinical features of endometria...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(01)00815-1
更新日期:2002-04-08 00:00:00
abstract:AIM:the ability of the breast cancer-associated placental acid isoform of ferritin (p43-PLF) to modulate cell surface expression of HLA, CD59 (protectin) and CD66 antigen (adhesion antigen related to CEA) was examined. METHODS:the expression of these antigens in human breast carcinoma cell lines BT-20, T47D and MDA-MB...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(95)03831-g
更新日期:1995-07-20 00:00:00
abstract::Tumor promotion potential of diacylglycerol (DAG)-rich edible oil was examined using a two-stage mouse skin carcinogenesis model initiated with 7,12-dimethylbenz[a]anthracene (DMBA). Topical treatment with 75 mg DAG oil once a day for 5 days/week for 35 weeks caused papillomas in 4 of 23 (17%) DMBA-treated female ICR ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2008.10.016
更新日期:2009-03-08 00:00:00
abstract::Patients with Her2-positive breast cancer exhibit de novo resistance or develop acquired resistance in less than one year after Her2 targeting treatment, but the mechanism is not fully elucidated. Compensatory pathways such as the IGF-1R/IRS-1 pathway, are activated, leading to aberrant enhanced PI3K/Akt/mTOR pathway ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2019.08.008
更新日期:2019-11-01 00:00:00
abstract::The recurrence rate of soft tissue and bone sarcomas strongly correlates to the status of the surgical margin after excision, yet excessive removal of tissue may lead to distinct, otherwise avoidable morbidity. Therefore, adequate margination of sarcomas both pre- and intra-operatively is a clinical necessity that has...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2020.03.029
更新日期:2020-07-28 00:00:00
abstract::Grp75 is a stress-inducible mitochondrial chaperone which has a high homology to senescence-related protein, p66mot mortalin. In human cells the mortalin gene assigns to the locus of a putative tumor suppressor gene for myeloid malignancies. In order to study expression and localization of Grp75 and p66mot in human an...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(97)00270-x
更新日期:1997-11-11 00:00:00
abstract::Oncogenic pituitary homeobox 2 (PITX2), a de facto master regulator of developmental organ asymmetry, previously upregulated multidrug resistance (MDR) P-glycoprotein ABCB1 in A498 renal cell carcinoma (RCC) cells. The role of PITX2 isoforms in MDR cancers was investigated. Data mining correlated elevated PITX2 in >30...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2019.01.044
更新日期:2019-05-01 00:00:00
abstract::Hypoxia induces survival signals in hepatocellular carcinoma (HCC). We attempted to find a hypoxia-induced signal that could be used for modulating HCC cell death. Cellular retinoic acid binding protein-II (CRABP-II) expression was significantly increased in hypoxic HCC cells. Treatment with retinoic acid (RA), a liga...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2010.03.005
更新日期:2010-09-28 00:00:00
abstract::Ritalin (methylphenidate hydrochloride), Benzedrine (amphetamine sulfate), and Dexedrine (dextroamphetamine sulfate) were examined for oncogenicity using a serial line of Fischer rat embryo cells, which was previously shown to be a sensitive and accurate indicator of chemicals carcinogenic for rodents. At the concentr...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(78)80061-5
更新日期:1978-12-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide, which ranks as the sixth of cancer-related death. Despite the emergence of targeted therapy, advanced-stage HCC remains largely incurable due to low response rate and therapeutic resistance. In this review, we mainly focused on the current pro...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2019.114428
更新日期:2019-09-28 00:00:00
abstract:PURPOSE:According to the CAO-/ARO-/AIO-94 trial of the German Rectal Cancer Study Group, pre-operative 5-fluorouracil (5-FU)-based long-term chemoradiotherapy (CT/RT) is recommended for patients with rectal cancer UICC stage II/III. However, despite the local benefit of neoadjuvant treatment, the overall prognostic val...
journal_title:Cancer letters
pub_type: 临床试验,杂志文章
doi:10.1016/j.canlet.2008.07.008
更新日期:2008-12-18 00:00:00
abstract::To investigate if genomic instability exists in tumors with cytogenetically normal karyotypes, we analyzed four diploid cancer cell lines A204, CAL51, CH1 and SK-UT-1B. We detected subtle genomic changes in all four cell lines. More of these alterations were found in A204 and CH1 than in the microsatellite unstable li...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2008.03.003
更新日期:2008-08-18 00:00:00
abstract::Highly invasive and rapidly fatal, small-cell lung cancer (SCLC) has been an insurmountable gulf since discovery. Innate immunity plays a vital role in anti-tumor response, among which macrophages contribute to an indispensable character. Here, we found that macrophage infiltration in SCLC reduced significantly in a s...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2020.11.034
更新日期:2021-02-28 00:00:00
abstract::V600E being the most common mutation in BRAF, leads to constitutive activation of the MAPK signaling pathway. The majority of V600E BRAF positive melanoma patients treated with the BRAF inhibitor vemurafenib showed initial good clinical responses but relapsed due to acquired resistance to the drug. The aim of the pres...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2015.02.041
更新日期:2015-05-28 00:00:00
abstract::Adult T-cell leukemia (ATL) is a fatal malignancy caused by infection with human T lymphotropic virus type-1 (HTLV-1). To search for a new biomarker of ATL, we analyzed sera from ATL patients using ProteinChip arrays. The spectral comparison of ATL patients with HTLV-1 carriers and healthy volunteers showed that the i...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2008.06.004
更新日期:2008-11-18 00:00:00
abstract::Sprague-Dawley rats were injected weekly with either 1,2-dimethylhydrazine (DMH) or methylazoxymethanol acetate (MAM). Addition of 4 ppm selenium (sodium selenite) in the drinking water reduced the number of rats developing DMH-induced colon tumors from 13 to 6 groups of 15 each. The total number of tumors observed in...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(77)80002-5
更新日期:1977-01-01 00:00:00