MnSOD polymorphism and breast cancer in a population-based case-control study.

Abstract:

:A polymorphism in the signal sequence (Ala-9Val) of the gene encoding the free radical-quenching manganese superoxide dismutase (MnSOD) has been reported to alter the risk for breast cancer. We evaluated this relationship in a population-based case-control study (476 breast cancer cases and 502 controls). Overall, relative risks were not significantly elevated in women with one (RR: 1.27; 95% CI: 0.91-1.77) or two (RR: 1.18; 95% CI: 0.81-1.73) Ala alleles compared to those homozygous for the wild-type Val genotype. Results do not support any overall association of the Ala-9Val MnSOD polymorphism to the development of breast cancer.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Egan KM,Thompson PA,Titus-Ernstoff L,Moore JH,Ambrosone CB

doi

10.1016/s0304-3835(03)00349-5

keywords:

subject

Has Abstract

pub_date

2003-09-10 00:00:00

pages

27-33

issue

1

eissn

0304-3835

issn

1872-7980

pii

S0304383503003495

journal_volume

199

pub_type

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