Abstract：
:By comparing protein profiles of nasopharyngeal carcinoma HONE1 cells to transformed nasopharyngeal epithelial NP 69 cells, several clusters of differentially expressed proteins were identified. The increased expression of cytokeratin 8 (CK8) and pyruvate kinase M2 was a common feature in four NPC cell lines compared to the two transformed epithelial cell lines. Suppression of CK8 was associated with the sensitivity to cisplatin in HONE1 cells; while overexpression of CK8 provided resistance to cisplatin-mediated apoptosis; and this protection occurred through an enhanced phosphorylation of c-Jun NH(2)-terminal kinase (JNK). Our findings implicate an underlying molecular mechanism in which CK8 is required for cisplatin resistance.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Wang Y,He QY,Tsao SW,Cheung YH,Wong A,Chiu JFdoi
10.1016/j.canlet.2008.02.015subject
Has Abstractpub_date
2008-07-08 00:00:00pages
188-96issue
2eissn
0304-3835issn
1872-7980pii
S0304-3835(08)00102-Xjournal_volume
265pub_type
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