Timing of N-methyl-N-nitrosourea administration affects gastric carcinogenesis in Mongolian gerbils infected with Helicobacter pylori.

abstract：:Despite the improved 5-year survival rate of breast cancer, triple-negative breast cancer (TNBC) remains a challenge due to lack of effective targeted therapy and higher recurrence and metastasis than other subtypes. To identify novel druggable targets and to understand its unique biology, we tried to implement 24 pat...

journal_title：Cancer letters

authors： Jung J,Jang K,Ju JM,Lee E,Lee JW,Kim HJ,Kim J,Lee SB,Ko BS,Son BH,Lee HJ,Gong G,Ahn SY,Choi JK,Singh SR,Chang S

更新日期：2018-08-01 00:00:00

abstract：:Avemar (MSC) is a nontoxic fermented wheat germ extract demonstrated to significantly improve the survival rate in patients suffering from various malignancies. We investigated its effects in human HL-60 promyelocytic leukemia cells. After 24, 48, and 72 h of incubation, Avemar inhibited the growth of HL-60 cells with...

journal_title：Cancer letters

authors： Saiko P,Ozsvar-Kozma M,Madlener S,Bernhaus A,Lackner A,Grusch M,Horvath Z,Krupitza G,Jaeger W,Ammer K,Fritzer-Szekeres M,Szekeres T

更新日期：2007-06-08 00:00:00

abstract：:Hypoxia causes upregulation of vascular endothelial growth factor (VEGF) which is a key regulator in tumor angiogenesis and essential for the proliferation of endothelial cells. Endothelial cells have been described to accumulate radiotracers like (18)F-FDG. However, the contribution of radiotracer uptake by endotheli...

journal_title：Cancer letters

authors： Oswald J,Treite F,Haase C,Kampfrath T,Mäding P,Schwenzer B,Bergmann R,Pietzsch J

更新日期：2007-08-28 00:00:00

abstract：:The binding of hematoporphyrin (HP) to human cells of the line NHIK 3025 has been studied with the aid of microfluorometry. HP is concentrated within cells when present in Hank's balanced salt solution in the concentration range 10(-5)--3 x 10(-3) M. The time course of binding is biphasic with a rapid initial binding ...

journal_title：Cancer letters

authors： Christensen T,Moan J

更新日期：1980-04-01 00:00:00

abstract：:We investigated the anticancer activity of erufosine in oral squamous carcinoma cell lines in terms of cell proliferation, colony formation, induction of autophagy/apoptosis, cell cycle and mTOR signaling pathway. Erufosine showed dose-dependent cytotoxicity in all cell lines, it induced autophagy as well as apoptosis...

journal_title：Cancer letters

authors： Kapoor V,Zaharieva MM,Das SN,Berger MR

更新日期：2012-06-01 00:00:00

abstract：:Application of functional imaging to radiotherapy (RT) is a rapidly expanding field with the development of new modalities and techniques. Functional imaging of PET in conjunction with RT provides new avenues towards the clinical application of dose painting - a new RT strategy delivering optimized dose redistribution...

journal_title：Cancer letters

authors： Shi X,Meng X,Sun X,Xing L,Yu J

更新日期：2014-12-28 00:00:00

abstract：:The p53 tumor suppressor gene is often mutated in various human cancers. Recently, the p53 codon 72 polymorphism has been extensively studied to determine the risk factors responsible for cancer formation. We investigated the genotype distribution of the p53 codon 72 polymorphism in 112 male urothelial cancer cases an...

journal_title：Cancer letters

authors： Kuroda Y,Tsukino H,Nakao H,Imai H,Katoh T

更新日期：2003-01-10 00:00:00

abstract：:HER-2 is overexpressed in 20-25% of invasive breast cancers and is associated with an aggressive tumor phenotype and reduced survival rate. The HER-2 status of a tumor is the critical determinant of response to the HER-2-targeted antibody Herceptin. Thus, accurate assessment of HER-2 expression levels is essential for...

journal_title：Cancer letters

authors： Nahta R,Esteva FJ

更新日期：2006-02-08 00:00:00

abstract：:In a series of invasive ductal breast carcinoma, we investigated the status of chromosomal and intrachromosomal instability by fluorescence in situ hybridisation and determined the level of mRNA expression for two genes involved in the mitotic spindle checkpoint pathway, BUB1B and MAD2L1. All breast cancers demonstrat...

journal_title：Cancer letters

authors： Scintu M,Vitale R,Prencipe M,Gallo AP,Bonghi L,Valori VM,Maiello E,Rinaldi M,Signori E,Rabitti C,Carella M,Dallapiccola B,Altomare V,Fazio VM,Parrella P

更新日期：2007-09-08 00:00:00

abstract：:p66(Shc), one of the SHC1 gene encoding proteins, promotes cell death and reports cell anchorage status, mediating anoikis in vitro and functioning as a metastasis suppressor in vivo. However, very little is known about p66(Shc) gene regulation in cancer cells. Here, we show that methylation of a specific CpG site in ...

journal_title：Cancer letters

authors： Du W,Jiang Y,Zheng Z,Zhang Z,Chen N,Ma Z,Yao Z,Terada L,Liu Z

更新日期：2013-08-28 00:00:00

abstract：:The identification of frameshift mutations in the coding region of the bax gene in Western cases of hereditary non-polyposis colorectal cancer provided evidence that the disease could be caused by the disruption of a tumor suppressor gene associated with microsatellite instability. In order to determine whether this o...

journal_title：Cancer letters

authors： Sakakibara T,Nakamura T,Yamamoto M,Matsuo M

更新日期：1998-02-27 00:00:00

abstract：:Patients (459) with chronic gastritis, ulcers, polyposis and different types of gastric cancers were examined by endoscopic fluorescent technique using a special drug based on the sodium salt of fluorescein (F1). Eighty-five percent of gastric cancers showed positive fluorescence. The F1 distribution in the stomach of...

journal_title：Cancer letters

authors： Braginskaja OV,Lazarev VV,Polsachev VI,Rubin LB,Stoskii VE

更新日期：1993-04-30 00:00:00

abstract：:We describe here the establishment of a new synovial sarcoma cell line, SYO-1, derived from a biphasic synovial sarcoma that developed in the groin of a 19-year-old female. The cell line was maintained for more than 70 passages (more than 24 months) in vitro. The SYO-1 cells in monolayer culture exhibited a spindle sh...

journal_title：Cancer letters

authors： Kawai A,Naito N,Yoshida A,Morimoto Y,Ouchida M,Shimizu K,Beppu Y

更新日期：2004-02-10 00:00:00

abstract：:Calcium channel blockers of 3 chemical classes and calmodulin antagonists have recently been shown to enhance the cytotoxicity of conventional cancer chemotherapeutic agents. We tested the ability of nifedipine, a dihydropyridine class calcium channel blocker, to enhance the cytotoxicity of cisplatin, the current chem...

journal_title：Cancer letters

authors： Onoda JM,Jacobs JR,Taylor JD,Sloane BF,Honn KV

更新日期：1986-02-01 00:00:00

abstract：:In vitro cytotoxicity tests currently in use applied in the developmental stages of anticancer drug discovery are able to select the most potent compounds, but are not predictive of their potential toxicity. In this study, we have demonstrated the applicability of neutral red uptake assay using mouse fibroblasts Balb/...

journal_title：Cancer letters

authors： Popiołkiewicz J,Polkowski K,Skierski JS,Mazurek AP

更新日期：2005-11-08 00:00:00

abstract：:Virtually all cervical cancer morbidities are associated with genital skin or mucosa cell infection with human papillomavirus (HPV). The HPV oncogenic proteins E6 and E7 are able to inactivate p53 and Rb proteins, which results in malignant transformation. Employing quantitative real-time PCR and Western blot analysis...

journal_title：Cancer letters

authors： Luczak MW,Jagodzinski PP

更新日期：2008-12-08 00:00:00

abstract：:The kinase insert domain-containing receptor (KDR) is the human vascular endothelial growth factor (VEGF) receptor responsible for the mitogenic and angiogenic effects of VEGF. There is much experimental evidence to suggest that the VEGF/KDR pathway plays an important role in tumor angiogenesis, a process essential fo...

journal_title：Cancer letters

authors： Zhu Z,Lu D,Kotanides H,Santiago A,Jimenez X,Simcox T,Hicklin DJ,Bohlen P,Witte L

更新日期：1999-03-01 00:00:00

abstract：:We have successfully generated cytotoxic monoclonal antibodies against a rat histiocytoma, AK-5. Monoclonal antibodies obtained after fusing immunized rat splenocytes with SP2/0 myeloma, were cytotoxic to AK-5 cells in the presence of complement. These monoclonals were highly specific and did not show any cross reacti...

journal_title：Cancer letters

authors： Khar A,Varalakshmi C,Pardhasaradhi BV,Ali AM

更新日期：1992-06-15 00:00:00

abstract：:Immune checkpoint blockade (ICB) has revolutionised the treatment of solid tumours, yet most patients do not derive a clinical benefit. Resistance to ICB is often contingent on the tumour microenvironment (TME) and modulating aspects of this immunosuppressive milieu is a goal of combination treatment approaches. Radia...

journal_title：Cancer letters

authors： Donlon NE,Power R,Hayes C,Reynolds JV,Lysaght J

更新日期：2021-01-12 00:00:00

abstract：:Inherent DNA damage in the form of single strand breaks and alkali labile sites is generated by essential intracellular processes, such as DNA replication and repair. Utilizing the in situ DNA unwinding assay and the comet assay (single cell gel), we have observed high levels of alkali induced DNA strand breaks in cel...

journal_title：Cancer letters

authors： Fairbairn DW,Reyes WA,O'Neill KL

更新日期：1994-06-15 00:00:00

abstract：:N-[2-(p-bromocinnamylmethylamino) ethyl]-5-isoquinolinesulfonamide (H-87), a newly synthesized inhibitor of protein kinase A, significantly decreased the drug resistance of multidrug resistant human U937/M cells, mouse FM3A/M and P388/M cells. Northern blot analysis showed MDR1 gene expression was decreased in H-87-tr...

journal_title：Cancer letters

authors： Kim SH,Park JI,Chung BS,Kang CD,Hidaka H

更新日期：1993-10-15 00:00:00

abstract：:The effect of different tannin-containing aqueous solutions on the carcinogenic action of benzo(a)pyrene (BP) on the mouse skin was investigated. It was found that the appearance of tumours was accelerated in mice treated with either tea or an oak extract after a single application of BP. The time of appearance of tum...

journal_title：Cancer letters

authors： Bogovski P,Day N

更新日期：1977-07-01 00:00:00

abstract：:Our previous studies have shown that norepinephrine induces the migratory activity of human PC-3 prostate, SW 480 colon and MDA-MB-468 breast carcinoma cells. In contrast to these results, we show here that human ES-2 ovarian carcinoma cells have a reduced migratory activity after norepinephrine treatment. This inhibi...

journal_title：Cancer letters

authors： Bastian P,Balcarek A,Altanis C,Strell C,Niggemann B,Zaenker KS,Entschladen F

更新日期：2009-02-18 00:00:00

abstract：:By comparing protein profiles of nasopharyngeal carcinoma HONE1 cells to transformed nasopharyngeal epithelial NP 69 cells, several clusters of differentially expressed proteins were identified. The increased expression of cytokeratin 8 (CK8) and pyruvate kinase M2 was a common feature in four NPC cell lines compared ...

journal_title：Cancer letters

authors： Wang Y,He QY,Tsao SW,Cheung YH,Wong A,Chiu JF

更新日期：2008-07-08 00:00:00

abstract：:Starting with an extract derived from the bark of Mundulea sericea Willd. (Leguminosae) that was active in the process of inhibiting 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced ornithine decarboxylase activity (ODC) in cultured mouse epidermal ME 308 cells, the isoflavonoid munetone was isolated and identified ...

journal_title：Cancer letters

authors： Lee SK,Luyengi L,Gerhäuser C,Mar W,Lee K,Mehta RG,Kinghorn AD,Pezzuto JM

更新日期：1999-02-08 00:00:00

abstract：:A high-pressure liquid chromatographic (HPLC) method using a micro-particulate silica column and gradient elution was developed that separated 12-O-tetradecanoylphorbol-13-acetate (TPA) from 20-oxo-TPA; 12-O-tetradecanoylphorbol (TP); 13-O-acetylphorbol (PA), and from the diterpene alcohol, phorbol (P). A series of ot...

journal_title：Cancer letters

authors： Berry DL,Lieber MR,Fischer SM,Slaga TJ

更新日期：1977-09-01 00:00:00

abstract：:Recent studies in several tumor models indicated that treatment with angiogenic inhibitors may trigger induction of metastasis to other organs. Here we investigated modes of resistance and invasion in several tumor cell lines including 4T1 (breast), H460 (lung) and Colo205 (colorectal) using sunitinib at doses compara...

journal_title：Cancer letters

authors： Shojaei F,Simmons BH,Lee JH,Lappin PB,Christensen JG

更新日期：2012-07-01 00:00:00

abstract：:An apoptosis-inducing protein with molecular weight of 60 kDa has been purified from fetal bovine serum. The N-terminal amino acid sequence of this protein (e.g. I-P-L-D-P-V-A-G-Y-K) reveals that it is bovine fetuin, a fetal protein functioning to control embryogenesis. The apoptosis-inducing activity of fetuin is tot...

journal_title：Cancer letters

authors： Yu CL,Tsai MH

更新日期：2001-05-26 00:00:00

abstract：:Triple-negative breast cancer (TNBC) treatment offers only limited benefits, and it is very relevant given the significant number of deaths that it causes. DNA repair pathways can enable tumor cells to survive DNA damage that is induced by chemotherapeutic or radiation treatments. Histone deacetylase inhibitors (HDACi...

journal_title：Cancer letters

authors： Wu YH,Hong CW,Wang YC,Huang WJ,Yeh YL,Wang BJ,Wang YJ,Chiu HW

更新日期：2017-08-01 00:00:00

abstract：:In vitro cultured r/mHM-SFME-1 cells were injected into the hind foot pads of Balb/c mice. Metastasis was detected in the lungs of tumor-bearing mice by means of both PCR and histological methods. Primers for the PCR were set to amplify a 128 bp exon-1 sequence of the human c-Ha-ras1 gene which had been introduced int...

journal_title：Cancer letters

authors： Matano S,Ryoyama K,Nakamura S,Okada G,Nomura T

更新日期：1995-05-04 00:00:00