Abstract:
:We have successfully generated cytotoxic monoclonal antibodies against a rat histiocytoma, AK-5. Monoclonal antibodies obtained after fusing immunized rat splenocytes with SP2/0 myeloma, were cytotoxic to AK-5 cells in the presence of complement. These monoclonals were highly specific and did not show any cross reactivity with normal cells and ascitic tumors such as Zajdela ascites hepatoma or Meth A. One of the antibodies was conjugated to daunomycin and used in the chemotherapeutic treatment. Total regression of AK-5 histiocytoma was obtained after injection of daunomycin-MAb conjugate into tumor bearing animals suggesting the specific targeting of the antineoplastic drug to the tumor. The histology of the tumor sections showed extensive necrosis of the tumors after treatment of the animals with drug-MAb conjugate.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Khar A,Varalakshmi C,Pardhasaradhi BV,Ali AMdoi
10.1016/0304-3835(92)90077-9keywords:
subject
Has Abstractpub_date
1992-06-15 00:00:00pages
163-9issue
2eissn
0304-3835issn
1872-7980pii
0304-3835(92)90077-9journal_volume
64pub_type
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