Experimental hypoxia is a potent stimulus for radiotracer uptake in vitro: comparison of different tumor cells and primary endothelial cells.

abstract：:Both PTEN (encoding phosphate and tensin homologue) and p53 are known as cancer suppressor genes, and they are assumed that their gene mutations and loss of heterozygosity (LOH) occur frequently in various types of carcinoma. In the present study, we investigated both the p53 mutation and LOH of PTEN in 113 gastric ca...

journal_title：Cancer letters

authors： Oki E,Tokunaga E,Nakamura T,Ueda N,Futatsugi M,Mashino K,Yamamoto M,Watanabe M,Ikebe M,Kakeji Y,Baba H,Maehara Y

更新日期：2005-09-08 00:00:00

abstract：:Our purpose is to demonstrate the relationship between microvessel density (MVD), vascular cuffing (VC), vascular endothelial growth factor (VEGF) expression and clinicopathological parameters in ovarian cancer. Surgical specimens from 105 primary ovarian cancers were examined for vascularization and VEGF expression b...

journal_title：Cancer letters

authors： Ogawa S,Kaku T,Kobayashi H,Hirakawa T,Ohishi Y,Kinukawa N,Nakano H

更新日期：2002-02-08 00:00:00

abstract：:We present the data of 105 serum samples from 20 patients suffering from cervical cancer. Mean serum levels of basic fibroblast growth factor (bFGF) in patients with or without tumor present were 31.3 +/- 32.1 (minimum 0, maximum 156.7) pg/ml and 4.8 +/- 6.8 (minimum 0, maximum 29.6) pg/ml, respectively (P = 0.0001). ...

journal_title：Cancer letters

authors： Sliutz G,Tempfer C,Obermair A,Reinthaller A,Gitsch G,Kainz C

更新日期：1995-08-01 00:00:00

abstract：:Overexpression of HER-2/neu proto-oncogene is found in many human cancers including 20-30% of breast cancer and is a predictor of poor prognosis. To target breast cancer cells that overexpress HER-2/neu mRNA, we previously described a novel strategy that combines the principle of antisense (AS) and translational inhib...

journal_title：Cancer letters

authors： Li Z,Xia W,Fang B,Yan DH

更新日期：2001-12-28 00:00:00

abstract：:A hallmark of most cancer cells is an altered metabolism involving a shift to aerobic glycolysis with lactate production coupled with a higher uptake of glucose as the main source of energy. Lactate dehydrogenase 5 (LDH-5) catalyzes the reduction of pyruvate by NADH to form lactate, thus determining the availability o...

journal_title：Cancer letters

authors： Augoff K,Hryniewicz-Jankowska A,Tabola R

更新日期：2015-03-01 00:00:00

abstract：:N-nitrosobis(2-oxopropyl)amine (BOP)-induced pancreatic adenocarcinomas in Syrian hamsters produce considerable amounts of mucin. The mucin is immunogenic in rabbits and is predominately of A blood group antigenic specificity, as determined by immunodiffusion in agar gel. Indirect immunofluorescence studies with human...

journal_title：Cancer letters

authors： Runge RG,Pour P

更新日期：1980-10-01 00:00:00

abstract：:Heterocyclic amines (HCAs) present in cooked foods are suggested to be involved in human breast cancer development. Estrogen plays a pivotal role in mammary gland carcinogenesis. Therefore, we designed an in vivo experiment to investigate potential estrogenic effects of two HCAs, 2-amino-3-methylimidazo[4,5-f]quinolin...

journal_title：Cancer letters

authors： Kawamori T,Uchiya N,Watanabe K,Ohta T,Sugimura T,Wakabayashi K

更新日期：2001-01-10 00:00:00

abstract：:Human PRL-1, PRL-2, and PRL-3 tyrosine phosphatases induce the malignant transformation of epithelial cells. We tested the hypothesis that the oncogenic effects of PRL occur by increasing cellular proliferation. Cells stably transfected with PRL-1 or PRL-2 exhibited 2.7-3.3-fold increases over control cells in the rat...

journal_title：Cancer letters

authors： Werner SR,Lee PA,DeCamp MW,Crowell DN,Randall SK,Crowell PL

更新日期：2003-12-30 00:00:00

abstract：:Although the incidence is very low, the prognosis of anaplastic carcinoma of the thyroid is very poor regardless of the results of various therapeutic trials. We found that the mechanism of anti-cancer drug resistance in anaplastic carcinoma of the thyroid was not explicable only in terms of expression of the mdr1 and...

journal_title：Cancer letters

authors： Sugawara I,Arai T,Yamashita T,Yoshida A,Masunaga A,Itoyama S

更新日期：1994-07-29 00:00:00

abstract：:The capacity of the human adrenal gland to metabolize various xenobiotics was investigated. Adrenal microsomal and mitochondrial preparations showed a maximal absorption at 450 nm for dithionite-reduced cytochromes in the presence of carbon monoxide. Occasionally, absorption maxima at 448 nm were observed with both mi...

journal_title：Cancer letters

authors： Papadopoulos D,Seidegard J,Rydström J

更新日期：1984-02-01 00:00:00

abstract：:In situ markers for quantitative analysis of cell proliferation and apoptotic cell death have been used to evaluate both the proliferation level and net growth potential of preneoplastic nodules and malignant tumor tissues from rats experimentally induced for hepatocarcinogenesis by the dietary administration of 2-ace...

journal_title：Cancer letters

authors： Kong J,Ringer DP

更新日期：1996-08-02 00:00:00

abstract：:The addition of recombinant human interleukin-6 (rIL-6) to either soleus or extensor digitorum longus (EDL) muscle preparations did not affect the rate of protein breakdown as measured by the rate of tyrosine released to the medium. In addition, the presence of the cytokine did not influence either the rate of protein...

journal_title：Cancer letters

authors： García-Martínez C,López-Soriano FJ,Argilés JM

更新日期：1994-01-15 00:00:00

abstract：:Gastric cancers with and those without high-frequency microsatellite instability (MSI-H) represent distinctive pathways of carcinogenesis. The aim of this study was to clarify if expression of p53 related genes involved in angiogenesis is differentially regulated between these cancers. We systematically analyzed the e...

journal_title：Cancer letters

authors： Miyamoto N,Yamamoto H,Taniguchi H,Miyamoto C,Oki M,Adachi Y,Imai K,Shinomura Y

更新日期：2007-08-28 00:00:00

abstract：:The involvement by tumour of intervertebral foramina and the consequent invasion of the spinal space, accompanied or not by neurological symptoms, represent a well-recognised pattern of presentation of neuroblastoma. The main peculiarity of this condition stands in the fact that, in case of its late detection or inade...

journal_title：Cancer letters

authors： De Bernardi B,Balwierz W,Bejent J,Cohn SL,Garrè ML,Iehara T,Plantaz D,Simon T,Angelini P,Cama A,London WB,Kramer K,Katzenstein HM,Tortori-Donati P,Rossi A,D'Angio GJ,Evans AE

更新日期：2005-10-18 00:00:00

abstract：:Two hepatoma cell lines were incubated for 72 h with ATRA and its analog 13cisRA and according to MTT assay, Hep3B cells were highly susceptible whereas HepG2 cells were more resistant to the treatment. At the high concentration of 166 microM, retinoids were able to induce apoptosis in both cell lines and the highest ...

journal_title：Cancer letters

authors： Arce F,Gätjens-Boniche O,Vargas E,Valverde B,Díaz C

更新日期：2005-11-18 00:00:00

abstract：:It has been proposed that a 356 amino acid protein encoded by the MIM (Missing In Metastasis) gene on Chromosome 8q24.1, is a bladder cancer metastasis suppressor. Recently, Machesky and colleagues [Biochem. J. 371 (2003) 463] identified MIM-B, a 759 amino acid protein, of which the C-terminal 356 amino acids are almo...

journal_title：Cancer letters

authors： Nixdorf S,Grimm MO,Loberg R,Marreiros A,Russell PJ,Pienta KJ,Jackson P

更新日期：2004-11-25 00:00:00

abstract：:The effect of bile acids on the formation of azoxymethane induced aberrant crypt foci (ACF) was investigated using the fecal stream-excluded colons of colostomized F344 rats. The excluded colon was irrigated with saline or bile acids (1 mg/0.5 ml per day, 5 days/week) for 4 weeks. The mean numbers of ACF per colon in ...

journal_title：Cancer letters

authors： Lin CX,Umemoto A,Seraj MJ,Mimura S,Monden Y

更新日期：2001-08-28 00:00:00

abstract：:Transforming acidic coiled-coil protein 3 (TACC3) is a member of the TACC family, essential for mitotic spindle dynamics and centrosome integrity during mitosis. Mounting evidence suggests that deregulation of TACC3 is associated with various types of human cancer. However, the molecular mechanisms by which TACC3 cont...

journal_title：Cancer letters

authors： Ha GH,Park JS,Breuer EK

更新日期：2013-05-10 00:00:00

abstract：:Microphthalmia-associated transcription factor (MITF) is expressed in melanomas and has a critical role in melanocyte development and transformation. Because inhibition of MITF inhibits cell growth in melanoma, MITF is a potential therapeutic target molecule. Here, we report the identification of CH6868398, which has ...

journal_title：Cancer letters

authors： Aida S,Sonobe Y,Tanimura H,Oikawa N,Yuhki M,Sakamoto H,Mizuno T

更新日期：2017-11-28 00:00:00

abstract：:Costunolide, the predominant sesquiterpene lactone in Saussureae radix, has been reported to exhibit potent chemopreventive effects on carcinogenesis. Effects of costunolide on cellular activation induced by a tumor-promoting phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) were investigated using a reporter g...

journal_title：Cancer letters

authors： Fukuda K,Akao S,Ohno Y,Yamashita K,Fujiwara H

更新日期：2001-03-10 00:00:00

abstract：:To date, dozens of melanoma-associated antigens (MAGE) have been identified. Based on the differences in tissue-specific gene expression and gene structure, the MAGE family has been divided into two big subfamilies: MAGE-I and MAGE-II. MAGE-I genes were identified as a group of highly attractive targets for cancer imm...

journal_title：Cancer letters

authors： Sang M,Wang L,Ding C,Zhou X,Wang B,Wang L,Lian Y,Shan B

更新日期：2011-03-28 00:00:00

abstract：:Both insulin-like growth factor II (IGF2) and H19 gene are located on chromosome 11p15.5 in close vicinity to each other, and are imprinted on different parental alleles. Although the exact mechanism remains unclear, loss of imprinting (LOI) leading to the biallelic expression of IGF2 and H19 genes has recently been r...

journal_title：Cancer letters

authors： Wu MS,Wang HP,Lin CC,Sheu JC,Shun CT,Lee WJ,Lin JT

更新日期：1997-11-25 00:00:00

abstract：:The stability of P-glycoprotein expression by high and low expressing cells obtained by flow sorting from two cell lines established from colonic tumors was assessed. Low expressing cells rapidly recovered expression to a level that was comparable to that determined for uncloned cells. High expressing cells maintained...

journal_title：Cancer letters

authors： Frommel TO

更新日期：1995-08-01 00:00:00

abstract：:Endometrial cancer is the leading gynecologic cancer in women in the United States with 52,630 women predicted to be diagnosed with the disease in 2014. The objective of this study was to determine if progesterone (P4) receptor membrane component 1 (PGRMC1) influenced endometrial cancer cell viability in response to c...

journal_title：Cancer letters

authors： Friel AM,Zhang L,Pru CA,Clark NC,McCallum ML,Blok LJ,Shioda T,Peluso JJ,Rueda BR,Pru JK

更新日期：2015-01-28 00:00:00

abstract：:Osteosarcoma (OS) is the most common primary bone malignancy and is frequently lethal via metastasis to the lung. While surgical techniques and adjuvant chemotherapies have emerged to combat this deadly cancer, the 5-year survival rate has plateaued over the past four decades. Therapeutic progress has been notably poo...

journal_title：Cancer letters

authors： Zhao J,Dean DC,Hornicek FJ,Yu X,Duan Z

更新日期：2020-04-01 00:00:00

abstract：:Epstein-Barr virus (EBV) has been well documented in the aetiology of nasopharyngeal carcinoma (NPC), although its role as well as the genetic basis in the genesis of NPC have not been elucidated. The p53 gene mutations are infrequently found in NPC, but the expression of p53 protein, as well as bcl-2 oncoprotein, has...

journal_title：Cancer letters

authors： Niemhom S,Kitazawa S,Murao S,Kunachak S,Maeda S

更新日期：2000-11-28 00:00:00

abstract：:Inadequate immunity that occurs in a tumor environment is in part due to the presence of M2-type tumor-associated macrophages (TAMs). TGF-β has a multi-functional role in tumor development including modulating the biological activity of both the tumor and TAMs. In this study, using an in vitro TAM/tumor cell co-cultur...

journal_title：Cancer letters

authors： Peng J,Tsang JY,Li D,Niu N,Ho DH,Lau KF,Lui VC,Lamb JR,Chen Y,Tam PK

更新日期：2013-05-01 00:00:00

abstract：:The possibility that lithium ions stimulate growth of mammary tumors in vivo has been suggested by their mitogenic action in vitro on normal and neoplastic mammary epithelium [8] and their clinical use as stimulators of neutrophil production in tumor-bearing patients treated with cytotoxic drugs [14,15]. Three experim...

journal_title：Cancer letters

authors： Ziche M,Maiorana A,Oka T,Gullino PM

更新日期：1980-05-01 00:00:00

abstract：:The recurrence rate of soft tissue and bone sarcomas strongly correlates to the status of the surgical margin after excision, yet excessive removal of tissue may lead to distinct, otherwise avoidable morbidity. Therefore, adequate margination of sarcomas both pre- and intra-operatively is a clinical necessity that has...

journal_title：Cancer letters

authors： Baljer BC,Kolhe S,Chan CD,Nicoli F,Ghanbasha A,Brookes MJ,Gamie Z,Ghosh KM,Beckingsale TB,Saleh DB,Ragbir M,Gerrand CH,Jeys L,Knight JC,Petrides G,Rankin KS

更新日期：2020-07-28 00:00:00

abstract：:Pancreatic adenocarcinoma cells show characteristics of macrophages as phagocytosis and exocytosis. These phagocytic activities can be inhibited in macrophages by antirheumatic drugs, e.g. gold compounds and antimalarials. We have now tested the activity of auranofin and chloroquine to inhibit growth of a pancreatic t...

journal_title：Cancer letters

authors： Zeilhofer HU,Mollenhauer J,Brune K

更新日期：1989-01-01 00:00:00