Effect of bile acids on formation of azoxymethane-induced aberrant crypt foci in colostomized F344 rat colon.

Abstract:

:The effect of bile acids on the formation of azoxymethane induced aberrant crypt foci (ACF) was investigated using the fecal stream-excluded colons of colostomized F344 rats. The excluded colon was irrigated with saline or bile acids (1 mg/0.5 ml per day, 5 days/week) for 4 weeks. The mean numbers of ACF per colon in rats given cholic acid, deoxycholic acid (DCA), chenodeoxycholic acid (CDCA), lithocholic acid, and ursodeoxycholic acid (UDCA) were 160.8, 118.2, 227.8, 150.7 and 87.3, respectively, while that of the control was 174.0. The number of ACF was significantly larger in CDCA, but smaller in UDCA and DCA-treated rats than the control (P<0.01). DCA did not induce apoptosis in the colon under the present conditions.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Lin CX,Umemoto A,Seraj MJ,Mimura S,Monden Y

doi

10.1016/s0304-3835(01)00525-0

keywords:

subject

Has Abstract

pub_date

2001-08-28 00:00:00

pages

121-6

issue

2

eissn

0304-3835

issn

1872-7980

pii

S0304383501005250

journal_volume

169

pub_type

杂志文章
  • The influence of asbestos dust on the oncogenic transformation of C3H10T 1/2 cells.

    abstract::The cell transforming ability of asbestos dust was investigated using C3H10T 1/2 murine fibroblasts. In a series of experiments both crocidolite and amosite caused no increase in the number of transformed foci over that seen in cultures from untreated cells. The dusts, were, however, capable of augmenting the oncogeni...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/0304-3835(83)90071-x

    authors: Brown RC,Poole A,Fleming GT

    更新日期:1983-03-01 00:00:00

  • Morphological detection of cell kinetics and progesterone receptor expression during growth and regression of pregnancy-dependent mammary tumors of GRS/A mice.

    abstract::Cell kinetics (cell proliferation and cell death) and the expression of progesterone receptor (PgR) during growth and regression of pregnancy-dependent mammary tumors (PDMT) of female GRS/A mice were investigated on the histologic level. Cell proliferation was determined using monoclonal anti-proliferating cell nuclea...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/0304-3835(96)04306-6

    authors: Yang J,Senzaki H,Nambu H,Tsubura A

    更新日期:1996-08-23 00:00:00

  • Enhanced antitumor activity of adriamycin in combination with allopurinol.

    abstract::Xanthine oxidase reduction of adriamycin (Am) and daunorubicin (Dm) to their respective 7-deoxy aglycones is inhibited by allopurinol. Administered to DBA/2 mice with L1210 leukemia, allopurinol (60 mg/kg per day X 3) enhances the antitumor activity of adriamycin. ...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/0304-3835(83)90189-1

    authors: Schwartz HS

    更新日期:1983-08-01 00:00:00

  • Deoxypodophyllotoxin triggers parthanatos in glioma cells via induction of excessive ROS.

    abstract::Parthanatos is a new form of programmed cell death that is regulated by hyper-activated PARP-1, and is emerging as a new strategy to kill cancer cells. Deoxypodophyllotoxin (DPT) is a natural chemical that is found to induce cancer cell death, in which the role of parthanatos is unknown. Thus, we investigated this iss...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2015.11.044

    authors: Ma D,Lu B,Feng C,Wang C,Wang Y,Luo T,Feng J,Jia H,Chi G,Luo Y,Ge P

    更新日期:2016-02-28 00:00:00

  • neu mutations and loss of normal allele in schwannomas induced by N-ethyl-N-nitrosourea in rats.

    abstract::The mutational activation of the neu proto-oncogene was analyzed in schwannomas of the peripheral nervous system transplacentally induced by N-ethyl-N-nitrosourea (ENU) in rats. All nine primary schwannomas investigated contained a T-->A transversion mutation at nucleotide 2012 of the neu gene, leading to the substitu...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/0304-3835(93)90073-i

    authors: Ohgaki H,Vogeley KT,Kleihues P,Wechsler W

    更新日期:1993-06-15 00:00:00

  • The anti-obesity agent Orlistat is associated to increase in colonic preneoplastic markers in rats treated with a chemical carcinogen.

    abstract::Orlistat is an anti-obesity agent that increases the fecal fat excretion, which promotes colon carcinogenesis. Therefore, the present study was designed to verify the effects of Orlistat on the formation of rat colonic aberrant crypt foci (ACF) and cell proliferation evaluated by the PCNA method. Male Wistar rats rece...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2005.09.011

    authors: Garcia SB,Barros LT,Turatti A,Martinello F,Modiano P,Ribeiro-Silva A,Vespúcio MV,Uyemura SA

    更新日期:2006-08-28 00:00:00

  • Tannins from Syzygium guineense suppress Wnt signaling and proliferation of Wnt-dependent tumors through a direct effect on secreted Wnts.

    abstract::Triple-negative breast cancer (TNBC) and colon cancer (CC) are two stigmatic examples of poorly treatable tumors, whose progression critically depends upon hyperactivation of the Wnt signaling. Development of specific anti-Wnt inhibitors is required to develop drugs against these and other Wnt-dependent cancers. Natur...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2018.08.003

    authors: Koval A,Pieme CA,Queiroz EF,Ragusa S,Ahmed K,Blagodatski A,Wolfender JL,Petrova TV,Katanaev VL

    更新日期:2018-10-28 00:00:00

  • Effect of alcohol consumption, cigarette smoking and flushing response on esophageal cancer risk: a population-based cohort study (JPHC study).

    abstract::We examined the effect of alcohol consumption, cigarette smoking and flushing response on esophageal squamous cell carcinoma (ESCC) in a large-scale population-based cohort study. 44,970 middle-aged and older Japanese men were followed. A total of 215 cases of ESCC were newly diagnosed. Alcohol consumption and cigaret...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2008.10.020

    authors: Ishiguro S,Sasazuki S,Inoue M,Kurahashi N,Iwasaki M,Tsugane S,JPHC Study Group.

    更新日期:2009-03-18 00:00:00

  • A molecular study of EBV DNA and p53 mutations in nasopharyngeal carcinoma of Saudi Arab patients.

    abstract::Tumor biopsies obtained from 25 Saudi Arab patients with nasopharyngeal carcinoma (NPC) were examined for the presence of Epstein-Barr virus (EBV) DNA detected by the polymerase chain reaction (PCR) and for the incidence of p53 mutations screened by a combination of PCR, single strand conformation polymorphism (SSCP) ...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/0304-3835(94)90011-6

    authors: Nasrin N,Taiba K,Hannan N,Hannan M,al-Sedairy S

    更新日期:1994-07-29 00:00:00

  • Chemoprevention of NMU-induced rat mammary carcinoma with the combination of melatonin and 9-cis-retinoic acid.

    abstract::In experimental trials using the N-nitroso-N-methylurea (NMU)-induced rat mammary tumor model, a significant decrease in tumor incidence (to 5%) was observed in rats treated with melatonin and 9-cis-retinoic acid (9 cRA) compared to controls (55%). Although 9cRA alone decreased tumor incidence to 26%, this response di...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3835(01)00548-1

    authors: Teplitzky SR,Kiefer TL,Cheng Q,Dwivedi PD,Moroz K,Myers L,Anderson MB,Collins A,Dai J,Yuan L,Spriggs LL,Blask DE,Hill SM

    更新日期:2001-07-26 00:00:00

  • Transcriptional activation of H-ras, K-ras and N-ras proto-oncogenes in human bladder tumors.

    abstract::In this study we demonstrate the involvement of ras oncogenes in bladder cancer at the level of RNA overexpression. We examined 26 bladder specimens, consisting of paired tumor and adjacent normal tissue and found that H-ras transcripts were overexpressed in 39% of the specimens while K-ras and N-ras in 58% of total s...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/0304-3835(96)04372-8

    authors: Vageli D,Kiaris H,Delakas D,Anezinis P,Cranidis A,Spandidos DA

    更新日期:1996-10-22 00:00:00

  • A novel histone deacetylase inhibitor TMU-35435 enhances etoposide cytotoxicity through the proteasomal degradation of DNA-PKcs in triple-negative breast cancer.

    abstract::Triple-negative breast cancer (TNBC) treatment offers only limited benefits, and it is very relevant given the significant number of deaths that it causes. DNA repair pathways can enable tumor cells to survive DNA damage that is induced by chemotherapeutic or radiation treatments. Histone deacetylase inhibitors (HDACi...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2017.04.023

    authors: Wu YH,Hong CW,Wang YC,Huang WJ,Yeh YL,Wang BJ,Wang YJ,Chiu HW

    更新日期:2017-08-01 00:00:00

  • Effect of potent antiglucocorticoids on dexamethasone induced enzymes in cultured hepatoma and rat liver cells.

    abstract::The antagonism by 3 synthetic steroids of the induction of tyrosine aminotransferase and tryptophan dioxygenase by dexamethasone were compared in HTC and FAZA hepatoma cells and in isolated liver cells. It was observed: (i) the sensitivity of liver cells to glucocorticoid agonists and antagonists changed in relation t...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/0304-3835(85)90192-2

    authors: Santana MA,Chasserot-Bolaz S,Beck B,Pogson CI

    更新日期:1985-07-01 00:00:00

  • Trilostane, an inhibitor of 3β-hydroxysteroid dehydrogenase, has an agonistic activity on androgen receptor in human prostate cancer cells.

    abstract::The intracellular androgen metabolism and cell activity in prostate cancer cells with mutated (LNCaP-FGC) or wild-type (VCaP) androgen receptors in the presence of trilostane, an inhibitor of 3β-hydroxysteroid dehydrogenase, were examined. Trilostane suppressed the intracellular production of androstenedione, testoste...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2010.05.015

    authors: Takizawa I,Nishiyama T,Hara N,Hoshii T,Ishizaki F,Miyashiro Y,Takahashi K

    更新日期:2010-11-28 00:00:00

  • A comparison of adrenergic receptors of rat ascites hepatoma AH130 cells with those of normal rat hepatocytes.

    abstract::The pharmacological specificity of adrenergic receptors in the plasma membrane of rat ascites hepatoma AH130 cells was compared with that in normal rat hepatocytes. The number of [125I]iodocyanopindolol-binding sites was much greater in AH130 cells than in the hepatocytes. We characterized the alpha-adrenergic recepto...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/0304-3835(88)90069-9

    authors: Sanae F,Miyamoto K,Koshiura R

    更新日期:1988-04-01 00:00:00

  • Epigenetic silencing of HOPX contributes to cancer aggressiveness in breast cancer.

    abstract::Epigenetic silencing of HOPX has been shown to be frequent and specific in human cancers. HOPX is thought as a tumor suppressor gene and its promoter methylation is the main mechanism of down-regulation. In non-hereditary breast cancer, since roles of epigenetic modifications are more critical than in other cancers, t...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2016.10.017

    authors: Kikuchi M,Katoh H,Waraya M,Tanaka Y,Ishii S,Tanaka T,Nishizawa N,Yokoi K,Minatani N,Ema A,Kosaka Y,Tanino H,Yamashita K,Watanabe M

    更新日期:2017-01-01 00:00:00

  • Cancer chemopreventive agents, 4-phenylcoumarins from Calophyllum inophyllum.

    abstract::In a search for anti-tumor-promoting agents, we carried out a primary screening of ten 4-phenylcoumarins isolated from Calophyllum inophyllum L. (Guttiferae), by examining their possible inhibitory effects on Epstein--Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate in Raji ...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3835(01)00521-3

    authors: Itoigawa M,Ito C,Tan HT,Kuchide M,Tokuda H,Nishino H,Furukawa H

    更新日期:2001-08-10 00:00:00

  • Differences in the migration capacity of primary human colon carcinoma cells (SW480) and their lymph node metastatic derivatives (SW620).

    abstract::Two human cell lines, one established from a colon carcinoma (SW480) and the other from its lymph node metastasis (SW620), were compared with respect to their migration capacity employing a three-dimensional collagen matrix and time-lapse video recording. Non-motile cells were characterized by a round shape, whereas m...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3835(98)00201-8

    authors: Kubens BS,Zänker KS

    更新日期:1998-09-11 00:00:00

  • The actin-bundling protein TRIOBP-4 and -5 promotes the motility of pancreatic cancer cells.

    abstract::TRIOBP isoforms 4 and 5 (TRIOBP-4/-5) are an actin-bundling protein associated with hearing loss. Here, we showed that TRIOBP-4/-5 was up-regulated in human pancreatic carcinoma cells. Knockdown of TRIOBP-4/-5 led to a loss of filopodia and a decrease in cell motility. Confocal microscopy showed that re-expression of ...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2014.08.005

    authors: Bao J,Wang S,Gunther LK,Kitajiri S,Li C,Sakamoto T

    更新日期:2015-01-28 00:00:00

  • Recent advances in strategies for overcoming hypoxia in photodynamic therapy of cancer.

    abstract::The selectivity of photodynamic therapy (PDT) derived from the tailored accumulation of photosensitizing drug (photosensitizer; PS) in the tumor microenvironment (TME), and from local irradiation, turns it into a "magic bullet" for the treatment of resistant tumors without sparing the healthy tissue and possible adver...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2020.07.007

    authors: Pucelik B,Sułek A,Barzowska A,Dąbrowski JM

    更新日期:2020-11-01 00:00:00

  • Bacteria-derived minicells for cancer therapy.

    abstract::Bacteria are always a considerable tool for the cancer therapy. The bacteria-derived minicells are re-emerged as a promising drug delivery system for cancer therapy. The minicells are nano-sized, anucleated, non-dividing, and metabolically active cells produced by abnormal bacterial cell division that are able to tran...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2020.07.024

    authors: Ali MK,Liu Q,Liang K,Li P,Kong Q

    更新日期:2020-10-28 00:00:00

  • Mutagenicity of some congeners of benzidine in the Salmonella typhimurium assay system.

    abstract::The analogs of benzidine were assay for mutagenicity using Salmonella typhimurium TA-98 and TA-100 and a mouse liver enzyme preparation. Only 4-aminobiphenyl produced both frameshift and base pair substitution mutations and 3,3'-dichlorobenzidine was the only compound which was mutagenic without the mammalian enzyme f...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3835(78)93137-3

    authors: Lazear EJ,Louie SC

    更新日期:1978-01-01 00:00:00

  • Cucurbitacin B inhibits STAT3 and the Raf/MEK/ERK pathway in leukemia cell line K562.

    abstract::Cucurbitacin B is a natural anti-cancer compound found in Cucurbitaceae. Although the anti-cancer activity of cucurbitacin B in human leukemia cells has been reported, the underlining mechanism is still unclear. To clarify its anti-cancer activity and the mechanism of action, five different leukemia cell lines (CCRF-C...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2009.07.015

    authors: Chan KT,Li K,Liu SL,Chu KH,Toh M,Xie WD

    更新日期:2010-03-01 00:00:00

  • Association of inhibition of cell growth by O-phospho-L-tyrosine with decreased tyrosine phosphorylation.

    abstract::We have previously demonstrated that O-phospho-L-tyrosine (P-Tyr), a substrate for a wide range of PTPases, inhibits the growth of human renal cell carcinoma and human breast cancer cell lines and suppresses EGF-mediated EGFR tyrosine phosphorylation. We now show that P-Tyr inhibited the growth of the human hepatoma c...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/0304-3835(96)04164-x

    authors: Mishra S,Hamburger AW

    更新日期:1996-04-19 00:00:00

  • Significant allelic loss of ANX7region (10q21) in hormone receptor negative breast carcinomas.

    abstract::Loss of heterozygosity (LOH) in the 10q21 region that harbors the tumor suppressor gene ANX7-GTPase gene have been found in 35% of prostate tumors. Therefore, the rationale for this study is that this gene could also be implicated in breast pathogenesis as well. We investigated allelic losses in microsatellites of the...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2004.01.018

    authors: Leighton X,Srikantan V,Pollard HB,Sukumar S,Srivastava M

    更新日期:2004-07-16 00:00:00

  • Activation of blood coagulation and the activity of cancer procoagulant (EC 3.4.22.26) in breast cancer patients.

    abstract::The activity of cancer procoagulant (CP), prothrombin time (PT), activated partial thromboplastin time (APTT), the concentration of thrombin-antithrombin complexes (TAT) and the concentration of fibrinogen were analysed in blood of breast cancer patients scheduled for surgery. The serum level of CP activity was depend...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3835(99)00230-x

    authors: Mielicki WP,Tenderenda M,Rutkowski P,Chojnowski K

    更新日期:1999-11-01 00:00:00

  • Alphoid DNA nucleotide sequences from two human cell lines and the corresponding cis-diamminedichloroplatinum(II)-resistant sublines.

    abstract::In order to study the interaction between cis-diamminedichloroplatinum(II) (CDDP) and representative human DNA in a highly defined manner, alphoid sequence DNA was isolated from two human parental cancer lines (one of head and neck squamous cell origin, SCC-25, and one of breast carcinoma origin, MCF-7) as well as fro...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/0304-3835(88)90174-7

    authors: Chan V,Elliott KE,Herman TS,Teicher BA

    更新日期:1988-12-15 00:00:00

  • Overexpression of c-Jun induced by quercetin and resverol inhibits the expression and function of the androgen receptor in human prostate cancer cells.

    abstract::Previously, we reported that quercetin and resveratrol inhibit the function of androgen receptor (AR). Further studies showed that these two polyphenols caused an increase in expression of c-Jun as well as its phosphorylated form in a dose-dependent manner in prostatic cell lines. Gel shift assay showed that induced c...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2004.04.003

    authors: Yuan H,Pan Y,Young CY

    更新日期:2004-09-30 00:00:00

  • Stress-induced upregulation of TNFSF4 in cancer-associated fibroblast facilitates chemoresistance of lung adenocarcinoma through inhibiting apoptosis of tumor cells.

    abstract::Stress conditions induced by routine treatments might affect cancer-associated fibroblasts in lung adenocarcinoma. The present study tried to explore transcriptome changes in lung fibroblasts under chemotherapeutics, irradiation, and hypoxia, which were induced by chemotherapy, radiotherapy, and anti-angiogenesis ther...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2020.10.032

    authors: Li Y,Chen Y,Miao L,Wang Y,Yu M,Yan X,Zhao Q,Cai H,Xiao Y,Huang G

    更新日期:2021-01-28 00:00:00

  • Comparative metabolism and macromolecular binding of benzo[a]pyrene in explant cultures of human bladder, skin, bronchus and esophagus from eight individuals.

    abstract::Benzo[a]pyrene (B[a]P) metabolism and macromolecular binding have been studied in explants from 4 tissues, bladder, skin, bronchus and esophagus from 8 donors sampled within 4 h after death. Explants were incubated with [3H]benzo[a]pyrene for 24 h, then the metabolites extracted and analyzed by high-pressure liquid ch...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/0304-3835(83)90112-x

    authors: Selkirk JK,Nikbakht A,Stoner GD

    更新日期:1983-02-01 00:00:00