Abstract:
:The effect of bile acids on the formation of azoxymethane induced aberrant crypt foci (ACF) was investigated using the fecal stream-excluded colons of colostomized F344 rats. The excluded colon was irrigated with saline or bile acids (1 mg/0.5 ml per day, 5 days/week) for 4 weeks. The mean numbers of ACF per colon in rats given cholic acid, deoxycholic acid (DCA), chenodeoxycholic acid (CDCA), lithocholic acid, and ursodeoxycholic acid (UDCA) were 160.8, 118.2, 227.8, 150.7 and 87.3, respectively, while that of the control was 174.0. The number of ACF was significantly larger in CDCA, but smaller in UDCA and DCA-treated rats than the control (P<0.01). DCA did not induce apoptosis in the colon under the present conditions.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Lin CX,Umemoto A,Seraj MJ,Mimura S,Monden Ydoi
10.1016/s0304-3835(01)00525-0keywords:
subject
Has Abstractpub_date
2001-08-28 00:00:00pages
121-6issue
2eissn
0304-3835issn
1872-7980pii
S0304383501005250journal_volume
169pub_type
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