Abstract:
:In situ markers for quantitative analysis of cell proliferation and apoptotic cell death have been used to evaluate both the proliferation level and net growth potential of preneoplastic nodules and malignant tumor tissues from rats experimentally induced for hepatocarcinogenesis by the dietary administration of 2-acetylaminofluorene. The findings show that although tumors have a much higher level of cell proliferation than preneoplastic liver nodules, the nodules have a higher potential for net growth when apoptosis is taken into account. These results support a role for a decrease in apoptosis during the promotion stage of carcinogenesis.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Kong J,Ringer DPdoi
10.1016/0304-3835(96)04291-7subject
Has Abstractpub_date
1996-08-02 00:00:00pages
241-8issue
2eissn
0304-3835issn
1872-7980pii
0304383596042917journal_volume
105pub_type
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