N-nitrosation and N-nitration of morpholine by nitrogen dioxide: inhibition by ascorbate, glutathione and alpha-tocopherol.

abstract：:Cyclooxygenase-2 (COX-2) is a transcriptional target and downstream effector of the ErbB-1 (EGFR) and ErbB-2 signaling pathways. We found that anti-EGFR and anti-ErbB-2 antibodies inhibited ERK phosphorylation and downregulated COX-2 protein expression in HCA-7 human colon carcinoma cells. Both antibodies also augment...

journal_title：Cancer letters

authors： Half E,Sun Y,Sinicrope FA

更新日期：2007-06-28 00:00:00

abstract：:Although it is well known that ovarian endometriosis occasionally gives rise to ovarian cancers with specific histology such as endometrioid and clear cell carcinomas, its etiology is not fully understood. We have shown that a stressful microenvironment within the endometriotic cyst may lead to cancer development by i...

journal_title：Cancer letters

authors： Mandai M,Matsumura N,Baba T,Yamaguchi K,Hamanishi J,Konishi I

更新日期：2011-11-28 00:00:00

abstract：:Epidemiological reports suggest that Asians consuming a diet high in soy have a low incidence of clinically manifested prostate cancer. We have tested the hypothesis that life-time exposure to genistein, the primary isoflavone component of soy, is responsible for this protective effect. Lobund-Wistar rats were exposed...

journal_title：Cancer letters

authors： Wang J,Eltoum IE,Lamartiniere CA

更新日期：2002-12-01 00:00:00

abstract：:Microphthalmia-associated transcription factor (MITF) is expressed in melanomas and has a critical role in melanocyte development and transformation. Because inhibition of MITF inhibits cell growth in melanoma, MITF is a potential therapeutic target molecule. Here, we report the identification of CH6868398, which has ...

journal_title：Cancer letters

authors： Aida S,Sonobe Y,Tanimura H,Oikawa N,Yuhki M,Sakamoto H,Mizuno T

更新日期：2017-11-28 00:00:00

abstract：:Twenty C57BL/6 male and 20 C3H female mice carrying a methyl cholanthrene-induced fibrosarcoma received, daily, intraperitoneal injections of histamine dihydrochloride (1.8 mg or 6 mg histamine base/mouse). In all histamine-treated C57BL/6 mice, tumour growth was significantly slower than in control mice until day 18....

journal_title：Cancer letters

authors： Burtin C,Scheinmann P,Salomon JC,Lespinats G,Loisillier F,Canu P

更新日期：1981-04-01 00:00:00

abstract：:It has been proposed that a 356 amino acid protein encoded by the MIM (Missing In Metastasis) gene on Chromosome 8q24.1, is a bladder cancer metastasis suppressor. Recently, Machesky and colleagues [Biochem. J. 371 (2003) 463] identified MIM-B, a 759 amino acid protein, of which the C-terminal 356 amino acids are almo...

journal_title：Cancer letters

authors： Nixdorf S,Grimm MO,Loberg R,Marreiros A,Russell PJ,Pienta KJ,Jackson P

更新日期：2004-11-25 00:00:00

abstract：:Inhibition of angiogenesis provides a potential anti-cancer therapy. Here we describe a novel recombinant peptide composed of active fragments of two distinct angiogenesis inhibitors, platelet factor-4 (C-13 fragment) and vasostatin (N-terminal amino acids 135-164) with a nonpolar peptide bridge of Gly-Pro-Gly. This f...

journal_title：Cancer letters

authors： Li X,Jiang L,Wang Y,Xiao Y,Huang Y,Yao Q,Yang Y,Wu X

更新日期：2007-10-18 00:00:00

abstract：:Tyrosine kinase inhibitor (TKI) treatment is the first-line therapy for non-small cell lung cancer (NSCLC) caused by activating mutations of epidermal growth factor receptor (EGFR). However, acquired resistance to EGFR-TKI occurs almost inevitably. Aberrant activation of proto-oncogene MET has been known to confer EGF...

journal_title：Cancer letters

authors： Quan C,Chen Y,Wang X,Yang D,Wang Q,Huang Y,Petersen RB,Liu X,Zheng L,Li Y,Huang K

更新日期：2020-12-28 00:00:00

abstract：:A variety of metal-binding compounds have been found to exert anti-cancer activity. We postulated that N-acetylcysteine (NAC), which is a membrane-permeable metal-binding compound, might have anti-cancer activity in the presence of metals. We found that NAC/Cu(II) significantly alters growth and induces apoptosis in h...

journal_title：Cancer letters

authors： Zheng J,Lou JR,Zhang XX,Benbrook DM,Hanigan MH,Lind SE,Ding WQ

更新日期：2010-12-08 00:00:00

abstract：:Although brain tumors are classified as if their lineage were well understood, the relationship between the molecular events that specify neural cell lineage and brain tumors remains enigmatic. Traditionally, cell surface membrane antigens have served as biomarkers that distinguish brain tumor origin and malignancy. I...

journal_title：Cancer letters

authors： Seyfried NT,Huysentruyt LC,Atwood JA 3rd,Xia Q,Seyfried TN,Orlando R

更新日期：2008-05-18 00:00:00

abstract：:Dihydroambazone (DHA) is a water-soluble derivative of the experimental anticancer drug ambazone. In vitro, a combination of DHA and human recombinant tumor necrosis factor alpha (TNF) exerted a strong synergism of cytotoxicity against both mouse melanoma B16K cells and the TNF-sensitive mouse fibroblast line L-M (S)....

journal_title：Cancer letters

authors： Baumgart J,Gase K,Schulze W,Suehnel J,Gutsche W,Behnke D

更新日期：1990-11-05 00:00:00

abstract：:Four glycoglycerolipid analogues, 1-O-hexanoyl-2-O-beta-D-glucopyranosyl-sn-glycerol (1), 1-O-hexanoyl-2-O-beta-D-galactopyranosyl-sn-glycerol (2), 2-O-(6-O-hexanoyl-beta-D-galactopyranosyl)-sn-glycerol (3) and 2-O-(6-O-hexanoyl-alpha-D-galactopyranosyl)-sn-glycerol (4), potent in vitro inhibitors of 12-O-tetradecanoy...

journal_title：Cancer letters

authors： Colombo D,Compostella F,Ronchetti F,Scala A,Toma L,Kuchide M,Tokuda H,Nishino H

更新日期：2000-12-20 00:00:00

abstract：:Sorafenib is the approved systemic drug of choice for advanced hepatocellular carcinoma (HCC), but has demonstrated limited benefits because of drug resistance. 2-Methoxyestradiol (2ME2) has been shown to be a promising anticancer drug against various types of cancers and acts by dysregulating hypoxia-inducible factor...

journal_title：Cancer letters

authors： Ma L,Li G,Zhu H,Dong X,Zhao D,Jiang X,Li J,Qiao H,Ni S,Sun X

更新日期：2014-12-01 00:00:00

abstract：:Growing epidemiological evidence points out the carcinogenic hazard of inhaled aflatoxin B1 (AFB1) to the pulmonary system. Metabolism of AFB1 by lung microsomes and its binding to calf thymus DNA are reported for the first time in this paper. In addition, the ability of dietary butylated hydroxyanisole (BHA) to modul...

journal_title：Cancer letters

authors： Allameh A,Saxena M,Raj HG

更新日期：1988-05-01 00:00:00

abstract：:In experimental trials using the N-nitroso-N-methylurea (NMU)-induced rat mammary tumor model, a significant decrease in tumor incidence (to 5%) was observed in rats treated with melatonin and 9-cis-retinoic acid (9 cRA) compared to controls (55%). Although 9cRA alone decreased tumor incidence to 26%, this response di...

journal_title：Cancer letters

authors： Teplitzky SR,Kiefer TL,Cheng Q,Dwivedi PD,Moroz K,Myers L,Anderson MB,Collins A,Dai J,Yuan L,Spriggs LL,Blask DE,Hill SM

更新日期：2001-07-26 00:00:00

abstract：:Administration of mannoheptulose partially protected mice infected with Listeria monocytogenes against the lethal effect of a subsequent endotoxin challenge. The ability of these animals to produce tumour necrosis factor was however unaffected. Mannoheptulose was observed to reverse the hypoglycaemic effect of endotox...

journal_title：Cancer letters

authors： Choy YM,Cheng CP,Luey LU,Loh SC,Fung KP,Lee CY

更新日期：1987-10-01 00:00:00

abstract：:The RB-E2F1 pathway is an important mechanism of cell-cycle control, and deregulation of this pathway is one of the key factors contributing to tumorigenesis. Cyclin-dependent kinases (CDKs) and Cyclin D have been known to increase in aggressive thyroid cancer. However, there has been no study to investigate effects o...

journal_title：Cancer letters

authors： Lee HJ,Lee WK,Kang CW,Ku CR,Cho YH,Lee EJ

更新日期：2018-03-28 00:00:00

abstract：:The primary aim of this study was to find novel chemopreventive agents effective against breast cancer. Endoplasmic reticulum (ER) stress can induce apoptosis through the unfolded protein response (UPR). 2'-Hydroxy-2,3,5'-trimethoxychalcone (DK143) is a synthetic flavonoid derivative. The present study provides eviden...

journal_title：Cancer letters

authors： Lee DH,Jung Jung Y,Koh D,Lim Y,Lee YH,Shin SY

更新日期：2016-03-01 00:00:00

abstract：:Not-targeted effects represent a paradigm shift from the "DNA centric" view that ionizing radiation only elicits biological effects and subsequent health consequences as a result of an energy deposition event in the cell nucleus. While this is likely true at higher radiation doses (>1 Gy), at low doses (<100 mGy) non-...

journal_title：Cancer letters

authors： Morgan WF,Sowa MB

更新日期：2015-01-01 00:00:00

abstract：:The kinetics of total DNA adducts were compared in the liver, bladder epithelium and small intestinal epithelium of rats and mice following a single oral dose (100 mg/kg) of 3,3'-dichlorobenzidine [( 14C]DCB). Peak DNA binding (expressed as pmol DCB bound/mg DNA) in rat tissues was 153.5, 144.8 and 36.9 in the intesti...

journal_title：Cancer letters

authors： Ghosal A,Iba MM

更新日期：1990-09-01 00:00:00

abstract：:The 825C>T polymorphism in the gene for the G-protein beta3 subunit (GNB3) has been linked to the occurrence of a splice variant of GNB3 and distinct cellular and metabolic features and may be associated with malignant disease. 500 patients with histologically confirmed breast cancer and 500 female age-matched healthy...

journal_title：Cancer letters

authors： Krippl P,Langsenlehner U,Renner W,Yazdani-Biuki B,Wolf G,Wascher TC,Paulweber B,Samonigg H

更新日期：2004-03-31 00:00:00

abstract：:p66(Shc), one of the SHC1 gene encoding proteins, promotes cell death and reports cell anchorage status, mediating anoikis in vitro and functioning as a metastasis suppressor in vivo. However, very little is known about p66(Shc) gene regulation in cancer cells. Here, we show that methylation of a specific CpG site in ...

journal_title：Cancer letters

authors： Du W,Jiang Y,Zheng Z,Zhang Z,Chen N,Ma Z,Yao Z,Terada L,Liu Z

更新日期：2013-08-28 00:00:00

abstract：:The time-dependent promotion activity of 17beta-estradiol (E2) by initiation with N-ethyl-N-nitrosourea (ENU) on induction of mouse uterine endometrial proliferative lesions was examined. Illumination-induced persistent estrous female CD-1 mice were divided into five groups at 9 weeks of age. At 10 weeks of age, mice ...

journal_title：Cancer letters

authors： Takahashi M,Nishimura S,Miyajima K,Sasahara K,Yoshida M,Ando J,Maekawa A

更新日期：2001-04-26 00:00:00

abstract：:Breast cancer, especially triple-negative breast cancer (TNBC), has limited treatment options. We repurposed the FDA-approved drug bazedoxifene as a novel inhibitor of interleukin 6/glycoprotein 130 signaling. In this study, we investigated the inhibitory effects of bazedoxifene alone or in combination with paclitaxel...

journal_title：Cancer letters

authors： Fu S,Chen X,Lo HW,Lin J

更新日期：2019-04-28 00:00:00

abstract：:The comparative effects of the subchronic administration to rats of ethionine-supplemented and of chemically defined methyl-deficient diets on the hepatic levels of S-adenosylmethionine (SAM) and of ornithine decarboxylase (ODC), an enzyme marker of cell proliferation, were studied. Both treatments led to decreased he...

journal_title：Cancer letters

authors： Mikol YB,Poirier LA

更新日期：1981-08-01 00:00:00

abstract：:Bombesin (BBS) has been shown to promote pancreatic growth as well as the development of pancreatic (pre)neoplasia in rats. The present study was carried out to determine the effects of bombesin on pancreatic growth and on the development of pancreatic (pre)neoplastic lesions in hamsters treated with N-nitrosobis(2-ox...

journal_title：Cancer letters

authors： Meijers M,van Garderen-Hoetmer A,Lamers CB,Rovati LC,Jansen JB,Woutersen RA

更新日期：1991-07-26 00:00:00

abstract：:It is now increasingly evident that the immune system represents a barrier to tumor emergence, growth, and recurrence. Although this idea was originally proposed almost 50 years ago as the "immune surveillance hypothesis", it is commonly recognized that, with few rare exceptions, tumor cells always prevail. Thus, one ...

journal_title：Cancer letters

authors： Rodvold JJ,Mahadevan NR,Zanetti M

更新日期：2016-09-28 00:00:00

abstract：:Trastuzumab (or Herceptin), as the first erbB2-targeted therapy, has been successfully used to treat breast cancer patients with erbB2-overexpressing tumors. However, resistances to trastuzumab frequently occur, and novel strategies/agents are urgently needed to abrogate the resistant phenotype. Our current study expl...

journal_title：Cancer letters

authors： Huang X,Wang S,Lee CK,Yang X,Liu B

更新日期：2011-08-01 00:00:00

abstract：:To date, several kinds of immunomodulating monoclonal antibodies (mAbs) have been applied in clinical trials, such as anti-cytotoxic T-lymphocyte antigen-4 (anti-CTLA-4) mAb and anti-programmed death-1 (anti-PD-1) mAb. With the recent success of cancer immunotherapy, especially the checkpoint inhibitors, the renewed i...

journal_title：Cancer letters

authors： Teng F,Kong L,Meng X,Yang J,Yu J

更新日期：2015-08-28 00:00:00

abstract：:Cucurbitacin B is a natural anti-cancer compound found in Cucurbitaceae. Although the anti-cancer activity of cucurbitacin B in human leukemia cells has been reported, the underlining mechanism is still unclear. To clarify its anti-cancer activity and the mechanism of action, five different leukemia cell lines (CCRF-C...

journal_title：Cancer letters

authors： Chan KT,Li K,Liu SL,Chu KH,Toh M,Xie WD

更新日期：2010-03-01 00:00:00