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Radiotherapy combined with immune checkpoint blockade immunotherapy: Achievements and challenges.

Abstract：

:To date, several kinds of immunomodulating monoclonal antibodies (mAbs) have been applied in clinical trials, such as anti-cytotoxic T-lymphocyte antigen-4 (anti-CTLA-4) mAb and anti-programmed death-1 (anti-PD-1) mAb. With the recent success of cancer immunotherapy, especially the checkpoint inhibitors, the renewed interest in immunotherapy as a treatment modality has gained extensive attention. The irradiated tumor cell death can enhance antitumor immunity by inducing antigen expression on tumor cells and activating lymphocytes. Radiotherapy (RT) combined with immunotherapy has revealed promising outcomes in various animal models. However, this new paradigm is often considered as a medical spectacle without a unifying model, and its mechanisms have yet to be elucidated. The purpose of this review is to investigate previously published studies of radiotherapy combined with checkpoint blockades by the following aspects: exploring the potential mechanisms; identifying the most beneficial dose, fraction and target site for RT; finding an appropriate time window to combine these two treatments; and discussing the toxicity and suitable treatment evaluating criteria.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Teng F,Kong L,Meng X,Yang J,Yu J

doi

10.1016/j.canlet.2015.05.012

subject

Has Abstract

pub_date

2015-08-28 00:00:00

pages

23-9

issue

1

eissn

0304-3835

issn

1872-7980

pii

S0304-3835(15)00340-7

journal_volume

365

pub_type

杂志文章,评审

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