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Cloning of 67-kDa laminin receptor cDNA and gene expression in normal and malignant cell lines of the human lung.

Abstract：

:Cell-adhesive protein laminin and its specific receptor play an important role in the processes of cancer proliferation, invasion and metastasis. In the present study, we cloned the cDNAs of the 67-kDa laminin receptor both from a human lung cell line (IMR90) and from a human lung cancer cell line (SBC3), and determined the nucleotide sequences. In comparison with both cDNA sequences of the protein-coding region, three nucleotide differences were found. These differences in the secondary structure of the protein, however, were caused by nucleotide substitutions. It was also demonstrated that the level of 67-kDa-laminin receptor mRNA was higher in SBC3 than in IMR90.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Satoh K,Narumi K,Sakai T,Abe T,Kikuchi T,Matsushima K,Sindoh S,Motomiya M

doi

10.1016/0304-3835(92)90096-e

keywords:

subject

Has Abstract

pub_date

1992-03-15 00:00:00

pages

199-203

issue

3

eissn

0304-3835

issn

1872-7980

pii

0304-3835(92)90096-E

journal_volume

62

pub_type

杂志文章

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