Abstract:
:The therapeutic efficacy of antineoplastic purine analogs can be jeopardized by the emergence of drug-resistant mutant subpopulations of tumor cells. To determine whether such mutant populations might be eradicable in vivo with the type of HAT combination (hypoxanthine + an antifolate + thymidine) known to be selectively cytotoxic to them in vitro, 2 thioguanine-resistant BALB/c murine myeloma lines were transplanted into BALB/c mice to produce tumors capable of progressive growth in the absence of therapy. Treatment of these mice with a modified HAT regimen induced permanent tumor regressions in 37/44 mice; the same treatment was ineffective against tumors produced by a non-mutant myeloma line from which one of the mutant sublines had been derived.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Moolten FLdoi
10.1016/0304-3835(86)90152-7subject
Has Abstractpub_date
1986-06-01 00:00:00pages
305-9issue
3eissn
0304-3835issn
1872-7980pii
0304-3835(86)90152-7journal_volume
31pub_type
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