An inverse correlation between hepatic ornithine decarboxylase and S-adenosylmethionine in rats.

abstract：:We present here a new cell line, NOR-P1, established from a metastatic subcutaneous tumor of a patient with pancreatic cancer. The cells show rapid growth in culture with a doubling time of 16 h and high migration activity. Genetic and molecular analyses revealed high telomerase activity and a mutation in the K-ras on...

journal_title：Cancer letters

authors： Sato N,Mizumoto K,Beppu K,Maehara N,Kusumoto M,Nabae T,Morisaki T,Katano M,Tanaka M

更新日期：2000-07-31 00:00:00

abstract：:Cancer cells often exhibit altered epigenetic signatures that can misregulate genes involved in processes such as transcription, proliferation, apoptosis and DNA repair. As regulation of chromatin structure is crucial for DNA repair processes, and both DNA repair and epigenetic controls are deregulated in many cancers...

journal_title：Cancer letters

authors： Agarwal P,Jackson SP

更新日期：2016-10-01 00:00:00

abstract：:The therapeutic efficacy of antineoplastic purine analogs can be jeopardized by the emergence of drug-resistant mutant subpopulations of tumor cells. To determine whether such mutant populations might be eradicable in vivo with the type of HAT combination (hypoxanthine + an antifolate + thymidine) known to be selectiv...

journal_title：Cancer letters

authors： Moolten FL

更新日期：1986-06-01 00:00:00

abstract：:Diabetes mellitus type II (DM) and immune cell infiltration determine patient outcome in many tumor entities. Here we studied a possible link between the metabolic and immune cell status of OSCC patients. Glucose transporter (GLUT) 1 mRNA expression was elevated in all tumor samples, whereas other glycolytic markers s...

journal_title：Cancer letters

authors： Spanier G,Ugele I,Nieberle F,Symeou L,Schmidhofer S,Brand A,Meier J,Spoerl S,Krupar R,Rümmele P,Siska P,Renner K,Peter K,Gerken M,Beckhove P,Reichert TE,Kreutz M,Singer K

更新日期：2021-02-28 00:00:00

abstract：:These studies examined the impact of dietary corn oil and its major constituent fatty acids on the occurrence of 7,12-dimethylbenz[a]anthracene (DMBA)-induced mammary DNA adducts. In study 1, rats were fed diets containing 5, 10 or 20% corn oil for 2 weeks prior to DMBA treatment (25 mg/kg). Mammary DNA adducts increa...

journal_title：Cancer letters

authors： Schaffer EM,Milner JA

更新日期：1996-09-10 00:00:00

abstract：:Sprague-Dawley rats were injected weekly with either 1,2-dimethylhydrazine (DMH) or methylazoxymethanol acetate (MAM). Addition of 4 ppm selenium (sodium selenite) in the drinking water reduced the number of rats developing DMH-induced colon tumors from 13 to 6 groups of 15 each. The total number of tumors observed in...

journal_title：Cancer letters

authors： Jacobs MM,Jansson B,Griffin AC

更新日期：1977-01-01 00:00:00

abstract：:The regulator of G protein signaling 10 (RGS10) protein is a GTPase activating protein that accelerates the hydrolysis of GTP and therefore canonically inactivates G proteins, ultimately terminating signaling. Rheb is a small GTPase protein that shuttles between its GDP- and GTP-bound forms to activate mTOR. Since RGS...

journal_title：Cancer letters

authors： Altman MK,Alshamrani AA,Jia W,Nguyen HT,Fambrough JM,Tran SK,Patel MB,Hoseinzadeh P,Beedle AM,Murph MM

更新日期：2015-12-01 00:00:00

abstract：:Autophagy is a membrane process that results in the transporting of cellular contents to lysosomes for degradation. Autophagic cell death is another way of programed cell death called type II PCD, which has complicated connection with apoptosis, both of these two types of cell death play an important role in tumor dev...

journal_title：Cancer letters

authors： Xiong HY,Guo XL,Bu XX,Zhang SS,Ma NN,Song JR,Hu F,Tao SF,Sun K,Li R,Wu MC,Wei LX

更新日期：2010-02-01 00:00:00

abstract：:Hypoxia-inducible factor 1 alpha (HIF-1 alpha) that regulates genes involved in response to hypoxia and promotes neo-angiogenesis, is a transcriptional factor for vascular endothelial cell growth factor (VEGF). The aim of this study was to examine the expression of HIF-1 alpha and VEGF gene expressions and their relat...

journal_title：Cancer letters

authors： Nakayama K,Kanzaki A,Hata K,Katabuchi H,Okamura H,Miyazaki K,Fukumoto M,Takebayashi Y

更新日期：2002-02-25 00:00:00

abstract：:Pancreatic cancer remains a highly lethal malignancy. We have recently shown that simultaneous expression of Kras and mutant Tp53R175H promotes invasive ductal adenocarcinoma from pancreatic ductal cells. We hypothesized specific mutations in TP53 have divergent mechanisms of transforming ductal cells. In order to und...

journal_title：Cancer letters

authors： Polireddy K,Singh K,Pruski M,Jones NC,Manisundaram NV,Ponnela P,Ouellette M,Van Buren G,Younes M,Bynon JS,Dar WA,Bailey JM

更新日期：2019-07-01 00:00:00

abstract：:Malignant mesothelioma (MM) frequently exhibits Hippo signaling pathway inactivation (HPI) mainly due to NF2 and/or LATS2 mutations, which leads to the activation of YAP transcriptional co-activator. Here, we show antitumor effects of statin on MM cells with HPI, through the interplay of the mevalonate and Hippo signa...

journal_title：Cancer letters

authors： Tanaka K,Osada H,Murakami-Tonami Y,Horio Y,Hida T,Sekido Y

更新日期：2017-01-28 00:00:00

abstract：:Hyperthermia induces cell death and the usual endpoint to study this is the ability of the cells to form colonies. Hyperthermia is also known to alter membrane characteristics, especially transmembrane potential and this has been correlated with duration and degree of heating. The aim of the present study was to see t...

journal_title：Cancer letters

authors： Remani P,Ostapenko VV,Akagi K,Bhattathiri VN,Nair MK,Tanaka Y

更新日期：1999-10-01 00:00:00

abstract：:We previously identified Hop as over expressed in invasive pancreatic cancer cell lines and malignant tissues of pancreatic cancer patients, suggesting an important role for Hop in the biology of invasive pancreatic cancer. Hop is a co-chaperone protein that binds to both Hsp70/Hsp90. We hypothesised that by targeting...

journal_title：Cancer letters

authors： Walsh N,Larkin A,Swan N,Conlon K,Dowling P,McDermott R,Clynes M

更新日期：2011-07-28 00:00:00

abstract：:In order to understand the differences and similarities between tumorigenic and non-tumorigenic HeLaxhuman fibroblast hybrids, gene expression profiles were examined with synthetic oligonucleotide arrays containing nearly 7000 gene probe sets. We used two pairs of genetically related hybrids, each pair representing in...

journal_title：Cancer letters

authors： Nishizuka S,Winokur ST,Simon M,Martin J,Tsujimoto H,Stanbridge EJ

更新日期：2001-04-26 00:00:00

abstract：:Aurora-A (Aur-A) is a centrosome-associated serine/threonine kinase that is overexpressed in various cancers and potentially correlated with chemoresistance. In the Ara-C-sensitive leukemia cell lines, silencing of Aur-A by small interfering RNA transfection led to a significant increase in the Ara-C-induced cell deat...

journal_title：Cancer letters

authors： Cheong JW,Jung HI,Eom JI,Kim SJ,Jeung HK,Min YH

更新日期：2010-11-28 00:00:00

abstract：:V600E being the most common mutation in BRAF, leads to constitutive activation of the MAPK signaling pathway. The majority of V600E BRAF positive melanoma patients treated with the BRAF inhibitor vemurafenib showed initial good clinical responses but relapsed due to acquired resistance to the drug. The aim of the pres...

journal_title：Cancer letters

authors： Zubrilov I,Sagi-Assif O,Izraely S,Meshel T,Ben-Menahem S,Ginat R,Pasmanik-Chor M,Nahmias C,Couraud PO,Hoon DS,Witz IP

更新日期：2015-05-28 00:00:00

abstract：:The plant sterol guggulsterone has recently been shown to have anti-tumorigenic potential. This study was designed to investigate the anti-tumor efficacy of guggulsterone and to elucidate its molecular mechanisms in colon cancer. Guggulsterone significantly increased apoptosis in HT-29 cells by activating caspases-3 a...

journal_title：Cancer letters

authors： An MJ,Cheon JH,Kim SW,Kim ES,Kim TI,Kim WH

更新日期：2009-06-28 00:00:00

abstract：:Hamster liver S9 prepared from control animals and animals given 30% glucose in drinking water 48 h before killing was used in studies of benzo[a]pyrene (BaP) and aflatoxin (AFB1)-induced mutagenesis, metabolism of BaP and AFB1, and metabolite binding to calf thymus DNA. BAP-induced mutagenesis in Salmonella typhimuri...

journal_title：Cancer letters

authors： Rubano DC,Teel RW,Strother A

更新日期：1990-07-16 00:00:00

abstract：:The over-expression of N-myc down-regulated gene 1 (NDRG1) in hepatocellular carcinoma (HCC) was previously reported to correlate with vascular invasion and patient survival. Our current study aims to elucidate its functions in HCC. We found that it lacked the tumorigenic ability to promote soft agar colony formation ...

journal_title：Cancer letters

authors： Yan X,Chua MS,Sun H,So S

更新日期：2008-04-08 00:00:00

abstract：:We describe an optimized systematic screen of known kinases using osteosarcoma cell lines (KHOS and U-2OS) and a lentiviral-based short hairpin RNA (shRNA) human kinase library. CellTiter 96(R)AQueous One Solution Cell Proliferation Assay was used to measure cell growth and survival. We identified several kinases, inc...

journal_title：Cancer letters

authors： Duan Z,Ji D,Weinstein EJ,Liu X,Susa M,Choy E,Yang C,Mankin H,Hornicek FJ

更新日期：2010-07-28 00:00:00

abstract：:Resveratrol is a plant polyphenol found in grapes and red wine. It has been found to have beneficial effects on the cardiovascular system. Resveratrol also inhibits the growth of various tumor cell lines in vitro and inhibits carcinogenesis in vivo. In this study we examined the effect of resveratrol on growth of two ...

journal_title：Cancer letters

authors： Niles RM,McFarland M,Weimer MB,Redkar A,Fu YM,Meadows GG

更新日期：2003-02-20 00:00:00

abstract：:Time trends and the geographical variation of mortality from gastric cancer in Spain are analysed. The national (1961-1980) and the provincial (1975-1980) crude death rates as well as the age adjusted death rates were calculated using the population census (years 1960 and 1970) and the figures for national and provinc...

journal_title：Cancer letters

authors： Palmeiro R,Senra A,Garcia-Blanco P,Millan J

更新日期：1988-09-01 00:00:00

abstract：:MUTYH-associated polyposis (MAP) is an autosomal recessive condition predisposing to colorectal cancer, caused by constitutional biallelic mutations in the base excision repair (BER) gene MUTYH. Colorectal tumours from MAP patients display an excess of somatic G>T mutations in the APC and KRAS genes due to defective B...

journal_title：Cancer letters

authors： Tricarico R,Bet P,Ciambotti B,Di Gregorio C,Gatteschi B,Gismondi V,Toschi B,Tonelli F,Varesco L,Genuardi M

更新日期：2009-02-18 00:00:00

abstract：:A field for cancerization, or a field defect, is formed by the accumulation of genetic and epigenetic alterations in normal-appearing tissues, and is involved in various cancers, especially multiple cancers. Epigenetic alterations are frequently present in chronic inflammation-exposed tissues, but information on indiv...

journal_title：Cancer letters

authors： Takeshima H,Niwa T,Takahashi T,Wakabayashi M,Yamashita S,Ando T,Inagawa Y,Taniguchi H,Katai H,Sugiyama T,Kiyono T,Ushijima T

更新日期：2015-02-01 00:00:00

abstract：:Both PTEN (encoding phosphate and tensin homologue) and p53 are known as cancer suppressor genes, and they are assumed that their gene mutations and loss of heterozygosity (LOH) occur frequently in various types of carcinoma. In the present study, we investigated both the p53 mutation and LOH of PTEN in 113 gastric ca...

journal_title：Cancer letters

authors： Oki E,Tokunaga E,Nakamura T,Ueda N,Futatsugi M,Mashino K,Yamamoto M,Watanabe M,Ikebe M,Kakeji Y,Baba H,Maehara Y

更新日期：2005-09-08 00:00:00

abstract：:The aim of this study was to clarify candidate peptides for peptide-based specific immunotherapy of patients with oral squamous cell carcinoma (SCC). Thirteen peptides were examined for in vitro induction of peptide-specific CD8(+) T lymphocyte (CD8(+)TL) activity in peripheral blood mononuclear cells from 35 patients...

journal_title：Cancer letters

authors： Toyoshima T,Kumamaru W,Hayashida JN,Moriyama M,Kitamura R,Tanaka H,Yamada A,Itoh K,Nakamura S

更新日期：2012-09-01 00:00:00

abstract：:The tumorigenicity of 4-aminobiphenyl (4-ABP) and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) were studied in combination with caloric restriction in the male neonatal CD1 mouse bioassay. 4-ABP and PhIP exhibited moderate and weak tumorigenicity, respectively, in ad libitum fed mice; however, none of the ca...

journal_title：Cancer letters

authors： Von Tungeln LS,Bucci TJ,Hart RW,Kadlubar FF,Fu PP

更新日期：1996-07-12 00:00:00

abstract：:Putrescine (PU), spermidine (SPD) and spermine (SPM) levels in blood serum of MC Sa 1828 P-bearing rats have been studied in relation to tumour weight and the histological picture. A statistically significant increase of PU and SPD was found in the course of tumour development. Decrease in the level of polyamines in t...

journal_title：Cancer letters

authors： Kaminski K,Maslinski C,Stanosek J,Szczurek Z

更新日期：1987-01-01 00:00:00

abstract：:Ring1 and YY1 binding protein (RYBP) is a member of the Polycomb group (PcG) proteins and regulates cell growth through both PcG-dependent and -independent mechanisms. Our initial study indicated that RYBP is down-regulated in human non-small cell lung cancer (NSCLC) tissues. The present study determined the molecular...

journal_title：Cancer letters

authors： Voruganti S,Xu F,Qin JJ,Guo Y,Sarkar S,Gao M,Zheng Z,Wang MH,Zhou J,Qian B,Zhang R,Wang W

更新日期：2015-12-28 00:00:00

abstract：:Standard chemotherapeutic protocols, based on maximum tolerated doses, do not prevent nor overcome chemoresistance caused by the efflux transporter P-glycoprotein (Pgp). We compared the effects of two consecutive low doses versus a single high dose of doxorubicin in drug-sensitive Pgp-negative and drug-resistant Pgp-p...

journal_title：Cancer letters

authors： Riganti C,Gazzano E,Gulino GR,Volante M,Ghigo D,Kopecka J

更新日期：2015-05-01 00:00:00