Abstract:
:Aurora-A (Aur-A) is a centrosome-associated serine/threonine kinase that is overexpressed in various cancers and potentially correlated with chemoresistance. In the Ara-C-sensitive leukemia cell lines, silencing of Aur-A by small interfering RNA transfection led to a significant increase in the Ara-C-induced cell death rate through induction of mitochondria-mediated, caspase-dependent apoptosis. In contrast, combined treatment of the Ara-C-resistant leukemia cell lines with Aur-A siRNA and Ara-C remarkably enhanced the cell death rate via non-caspase-dependent mitotic catastrophe. Taken together, Aur-A inhibition was an effective treatment for both the Ara-C-sensitive and resistant leukemia cells by increasing apoptosis and mitotic catastrophe, respectively.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Cheong JW,Jung HI,Eom JI,Kim SJ,Jeung HK,Min YHdoi
10.1016/j.canlet.2010.05.009subject
Has Abstractpub_date
2010-11-28 00:00:00pages
171-81issue
2eissn
0304-3835issn
1872-7980pii
S0304-3835(10)00285-5journal_volume
297pub_type
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