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Candidate regions of tumor suppressor gene by loss of heterozygosity analysis on chromosome 8p11.1-q13.3 in gastric cancer.

Abstract：

:Loss of heterozygosity (LOH) is an important event of tumorigenesis. In this paper, we report the comprehensive LOH analyses with microsatellite markers and their results at chromosome 8p11.1-q13.3 in gastric cancer. The microsatellite markers D8S2323 and D8S2330 exhibited high LOH frequencies, 54.2 and 57.1%, respectively. However, LOH at 8q showed no relationship to either histological types or stages of gastric cancer. Finally, we settled six candidate regions on 8q in gastric cancer where there was a high possibility of being the tumor suppressor gene(s), and concluded that the LOH of 8q occurred in the primary tumorigenesis of gastric cancer.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Kakinuma N,Kohu K,Sato M,Yamada T,Nakajima M,Akiyama T,Ohwada S,Shibanaka Y

doi

10.1016/j.canlet.2004.03.041

keywords:

subject

Has Abstract

pub_date

2004-09-15 00:00:00

pages

111-6

issue

1

eissn

0304-3835

issn

1872-7980

pii

S0304383504002733

journal_volume

213

pub_type

杂志文章

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