Abstract：
:Cultures of normal human peripheral blood lymphocytes stimulated by phytohaemagglutinin (PHA) were treated with withaferin A and examined by an electron microscope. The compound was found to affect the spindle microtubules of cells in metaphase. There were no intact pole-to-pole microtubules or pole-to-kinetochore microtubules found in the treated cells; the centrioles were located in the center. Furthermore, cells at interphase were also affected, the membrane system of the cells being damaged.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Shohat B,Ben-Bassat M,Shaltiel A,Joshua Hdoi
10.1016/s0304-3835(76)80013-4keywords:
subject
Has Abstractpub_date
1976-11-01 00:00:00pages
63-70issue
2eissn
0304-3835issn
1872-7980pii
S0304-3835(76)80013-4journal_volume
2pub_type
杂志文章相关文献
CANCER LETTERS文献大全abstract：:Oxidative phosphorylation (OXPHOS) in cancer has attracted a considerable attention in the past decades, and accumulated evidence has suggested that it plays an important role in tumor proliferation, metastasis and drug resistance. However, the mechanisms involved in these effects are still ambiguous to date. In this ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2019.04.021
更新日期：2019-07-28 00:00:00
abstract：:The mechanism underlying the chemopreventive effects of the non-steroidal anti-inflammatory drug sulindac remains unclear. Its active metabolite, sulindac sulfide, induces cell cycle arrest as well as apoptosis in mammalian cell lines. We now show that in murine thymocytes, sulindac sulfide-induced cell death is p53, ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2004.06.015
更新日期：2005-02-28 00:00:00
abstract：:The mesenchymal (MES) subtype of glioblastoma (GBM) indicated a more malignant phenotype and worse prognosis compared with their proneural (PN) counterpart. The plasticity between PN and MES transcriptome signatures provided an approach for clinical intervention. However, few miRNAs have been identified to participate...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2017.03.002
更新日期：2017-06-28 00:00:00
abstract：:Aristolochic acid (AA), a naturally occurring nephrotoxin and carcinogen, has been associated with the development of urothelial cancer in humans. Using the 32P-postlabeling assay we showed that AAI is activated by human recombinant cytochrome P450 (CYP) 1A1, CYP1A2 and NADPH:CYP reductase to species generating DNA ad...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2005.06.038
更新日期：2005-11-18 00:00:00
abstract：:Tamoxifen (TAM)-induced DNA adduct formation in mouse skin was determined by a nuclease P1-enhanced 32P-postlabelling technique. Topical application of TAM significantly induced a number of DNA-adducts in mouse skin in a dose- and time-dependent manner. When SENCAR mice were topically treated with different doses of T...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(95)03802-4
更新日期：1995-06-08 00:00:00
abstract：:In situ markers for quantitative analysis of cell proliferation and apoptotic cell death have been used to evaluate both the proliferation level and net growth potential of preneoplastic nodules and malignant tumor tissues from rats experimentally induced for hepatocarcinogenesis by the dietary administration of 2-ace...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(96)04291-7
更新日期：1996-08-02 00:00:00
abstract：:Starting with an extract derived from the bark of Mundulea sericea Willd. (Leguminosae) that was active in the process of inhibiting 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced ornithine decarboxylase activity (ODC) in cultured mouse epidermal ME 308 cells, the isoflavonoid munetone was isolated and identified ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(98)00309-7
更新日期：1999-02-08 00:00:00
abstract：:The serial analysis of gene expression (SAGE) technique was used to generate a database of the most abundant transcripts of the MYCN-amplified neuroblastoma cell line IMR-5. A total of 8568 tags were sequenced and shown to represent 4034 unique tags, each of which corresponds to an individual transcript. Expression le...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(02)00581-5
更新日期：2003-02-10 00:00:00
abstract：:Multidrug-resistant MCF-7 breast adenocarcinoma cells (originally named MCF-7/AdrR cells and later re-designated NCI/ADR-RES) have served as an important and widely used research tool during the last two decades. However, the real identity of these cells has been in doubt since 1998 and has since been debated. The ori...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2006.01.013
更新日期：2007-01-08 00:00:00
abstract：:BAT monoclonal antibody exhibited anti-tumor activity mediated by T and NK cells. We have evaluated the efficacy of murine and humanized BAT for the treatment of human colorectal carcinoma liver metastases in nude mice. HM7, a human colorectal carcinoma was injected into the spleen to colonize the liver. A single intr...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2005.06.046
更新日期：2005-11-18 00:00:00
abstract：:Mutation of the p53 gene has been reported in hepatocellular carcinoma (HCC) occurring worldwide. The most frequent p53 mutation has been found in HCCs in regions with high hepatitis B virus (HBV) infection and intake of aflatoxin B1 (AFB1). The aim of our study was to examine p53 protein expression in HCCs from a hig...
journal_title：Cancer letters
pub_type： 临床试验,杂志文章
doi：10.1016/s0304-3835(97)00352-2
更新日期：1997-12-23 00:00:00
abstract：:Pancreatic cancer is an aggressive malignancy and unresponsive to conventional chemotherapies. Here, the anti-inflammatory and anti-tumor effects of embelin on pancreatic cancer were investigated. Embelin significantly attenuated cells invasion, proliferation and induced apoptosis through inhibition of STAT3 and activ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2014.08.011
更新日期：2014-11-28 00:00:00
abstract：:uPA system plays an important role in cancer invasion and metastasis. The binding of uPA to its receptor, uPAR, is necessary for the activation of uPA system. We studied by immunohistochemistry the distribution pattern of uPAR on 173 paraffin-embedded samples of invasive breast carcinomas in relation to clinicopatholo...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2006.03.003
更新日期：2007-02-08 00:00:00
abstract：:The age-standardized mortality rates by sex for cancer of all sites and some specific sites were calculated in the 22 areas of Rosario (Argentina). The rates by area were correlated with education, occupation, housing quality and population density, applying Kendall's tau. Cervical cancer rates showed the strongest co...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(90)90159-u
更新日期：1990-03-01 00:00:00
abstract：:Sulofenur treatment (12.5 microM-1 mM) of colon adenocarcinoma cell lines resulted in dose- and time-dependent cell killing. LYc5 cells were viable longer than GC3/c1 cells. Each concentration resulted in elevation of cytosolic calcium [Ca2+]i) for both cell lines. At lower doses, elevation was delayed for LYc5 cells....
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(94)03607-k
更新日期：1995-01-06 00:00:00
abstract：:Tumor-associated mesenchymal stem cells (MSCs) play a critical role in the growth and metastasis of hepatocellular carcinoma (HCC). However, the mechanism underlying the crosstalk between MSCs and HCC cells is not completely understood. Here, HCC cells were treated with or without conditioned medium of MSCs (CM-MSC), ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2021.01.011
更新日期：2021-01-17 00:00:00
abstract：:Tumor-associated macrophages (TAMs) are important immunocytes associated with cancer metastasis. However, whether TAMs play a dominant role in mediating CXCL12/CXCR4-induced liver metastasis of colorectal cancer (CRC) remains unexplored. Herein, we found that CD206+ TAMs, which infiltrated at the invasive front, were ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2020.01.005
更新日期：2020-04-01 00:00:00
abstract：:Artesunate (ART), a semi-synthetic derivative of artemisinin extracted from the Chinese herb Artemisia annua, is a safe and effective antimalarial drug. ART has now been analyzed for its anti-angiogenic activity in vivo and in vitro. The anti-angiogenic effect in vivo was evaluated on chicken chorioallantoic membrane ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2004.03.014
更新日期：2004-08-10 00:00:00
abstract：:We have developed a simple system for rapid detection and measurement of glutathione S-transferase placental form (GSTP1) that detoxify polycyclic aromatic hydrocarbons using the cultured rat normal liver epithelial cell line, (RL34) cells. Survey of fruit extracts for GST inducing ability identified both papaya and a...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(00)00487-0
更新日期：2000-09-01 00:00:00
abstract：:In this report we demonstrated that [3H]suramin enters polarized human colon adenocarcinoma cells when added to the apical side of the monolayer. Using light microscopic quantitative autoradiography, we showed that suramin was accumulated in the apical cytoplasm and in the nucleus. In contrast, a weak labeling was not...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(93)90057-g
更新日期：1993-12-20 00:00:00
abstract：:Post-transplant lymphoproliferative disorders (PTLDs) represent the most severe complication of both solid organ and hematopoietic stem cell transplantation. The Epstein-Barr Virus (EBV) is the main driver of PTLD, particularly those occurring early after transplantation. EBV-driven malignancies are associated with se...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2015.08.007
更新日期：2015-12-01 00:00:00
abstract：:5-fluorouracil (5-FU) is widely used in chemotherapy for colorectal cancer (CRC), but a high rate of chemoresistance reduces its effectiveness in clinical treatment. We found remarkably decreased expression of forkhead box 3 (FoxO3) protein, a tumor inhibitor, in 5-FU-resistant SW620 and HCT-8 (SW620/5-FU and HCT-8/5-...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2019.11.042
更新日期：2020-02-01 00:00:00
abstract：:Interferon-beta (IFN-β) is reported to augment anti-tumor effects by temozolomide in glioblastoma via down-regulation of MGMT. Promyelocytic leukemia (PML), a gene induced by IFN-β, is a tumor suppressor. Here, we report for the first time that in combination therapy, an IFN-β-induced increase in endogenous PML contri...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2012.04.013
更新日期：2012-10-28 00:00:00
abstract：:The acquisition and persistence of fetal microchimerism, small numbers of genetically disparate cells from the fetus in the mother, is now a well-recognized consequence of normal pregnancy. Fetal microchimerism has been associated with several classical autoimmune diseases, but its role in normal health remains undefi...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2008.07.025
更新日期：2009-04-08 00:00:00
abstract：:Relative frequencies of diethylnitrosamine (DEN)-initiated foci of altered hepatocytes appearing in response to promotion by either dietary phenobarbital or a topically applied coal-derived organic mixture (CDM) were investigated in male and female rats. The focus population was examined for two histochemical markers,...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(87)90155-8
更新日期：1987-10-30 00:00:00
abstract：:We evaluated the ability of brain-derived neurotrophic factor (BDNF) to decrease the chemosensitivity of neuroblastoma cells to cisplatin. Two cell lines, one derived from SH-SY5Y (SY5Y-TB8) and the other from SK-N-AS (AS-TB8), transfected with a TrkB plasmid were generated, and used to assess the effects of activatio...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(02)00723-1
更新日期：2003-04-10 00:00:00
abstract：:In this study we demonstrate the involvement of ras oncogenes in bladder cancer at the level of RNA overexpression. We examined 26 bladder specimens, consisting of paired tumor and adjacent normal tissue and found that H-ras transcripts were overexpressed in 39% of the specimens while K-ras and N-ras in 58% of total s...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(96)04372-8
更新日期：1996-10-22 00:00:00
abstract：:Low-frequency electromagnetic fields enhance the induction of mammary gland tumors in rats using nitrosomethyl urea. The incidence of tumors depended on the duration of exposure to static (dc) and variable (ac) magnetic fields. Variable magnetic fields induced mammary gland cancer much more frequently than static ones...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(91)90079-w
更新日期：1991-12-09 00:00:00
abstract：:Background is presented to suggest that a great many biologic processes are chaotic. It is well known that chaotic processes can be accurately characterized by non-linear technologies. Evidence is presented that an artificial neural network, which is a known method for the application of non-linear statistics, is able...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(94)90090-6
更新日期：1994-03-15 00:00:00
abstract：:In esophageal squamous cell carcinoma (SCC), we used immunohistochemical analysis to further elucidate the correlation of p53 protein expression with clinicopathological factors, as well as with risk factors, such as tobacco smoking, alcohol consumption and a family history of cancer, using odds ratios (ORs). The expr...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(01)00461-x
更新日期：2001-06-10 00:00:00
