Cancer chemopreventive activity of 3beta-methoxyserrat-14-en-21beta-ol and several serratane analogs on two-stage mouse skin carcinogenesis.

abstract：:We have demonstrated previously that a phosphorothioate antisense oligonucleotide to the p65 subunit of the inducible transcription factor NF-kappaB produced rapid changes in the expression of leukocyte integrin CD11b (Mo 1) and in the adhesion of dimethylsulfoxide (DMSO)-differentiated HL-60 cells stimulated by 12-O-...

journal_title：Cancer letters

authors： Sokoloski JA,Narayanan R,Sartorelli AC

更新日期：1998-03-13 00:00:00

abstract：:Glioblastoma (GBM) has limited therapeutic options. DNA repair mechanisms contribute GBM cells to escape therapies and re-establish tumor growth. Multiple studies have shown that POLD2 plays a critical role in DNA replication, DNA repair and genomic stability. We demonstrate for the first time that POLD2 is highly exp...

journal_title：Cancer letters

authors： Xu Q,Hu C,Zhu Y,Wang K,Lal B,Li L,Tang J,Wei S,Huang G,Xia S,Lv S,Laterra J,Jiang Y,Li Y

更新日期：2020-07-10 00:00:00

abstract：:Peroxiredoxin 2 (Prdx2) has been shown to act as an antioxidant whose main function is to reduce hydrogen peroxide (H2O2) in cells, and Prdx2 is abnormally elevated in colorectal cancer (CRC). However, the functional significance of this up-regulation and the detailed molecular mechanism behind the regulatory effect o...

journal_title：Cancer letters

authors： Lu W,Fu Z,Wang H,Feng J,Wei J,Guo J

更新日期：2014-02-28 00:00:00

abstract：:Cancer stem cells (CSCs) are involved in tumorigenesis and progression of prostate cancer (PCa). Conventional anticancer therapeutics failed to eradicate CSCs, which may eventually lead to the disease relapse and metastasis. Therefore, targeting prostate CSCs may be an ideal strategy to cure PCa. Genistein is a major ...

journal_title：Cancer letters

authors： Zhang L,Li L,Jiao M,Wu D,Wu K,Li X,Zhu G,Yang L,Wang X,Hsieh JT,He D

更新日期：2012-10-01 00:00:00

abstract：:Lysophosphatidic acid (LPA) receptors including LPA(1), LPA(2), and LPA(3) mediate lysophosphatidic acid signals. We analyzed the expression of LPA receptors, vascular endothelial growth factor (VEGF), and interleukin-8 in 97 patients from normal ovary to ovarian cancer, using reverse transcription polymerase chain re...

journal_title：Cancer letters

authors： Fujita T,Miyamoto S,Onoyama I,Sonoda K,Mekada E,Nakano H

更新日期：2003-03-31 00:00:00

abstract：:Immunohistochemically detected expression of sialyl Lewis(x) (Le(x)) antigen was analyzed in 101 stage 0-II gastric cancers to clarify its prognostic value after curative gastrectomy. Patients with a high-expression of sialyl Le(x) antigen within their tumors had shorter disease-specific intervals than those with nega...

journal_title：Cancer letters

authors： Nakagoe T,Fukushima K,Sawai T,Tsuji T,Jibiki Ma,Nanashima A,Tanaka K,Yamaguchi H,Yasutake T,Ayabe H,Arisawa K,Ishikawa H

更新日期：2002-01-25 00:00:00

abstract：:Disinfection of drinking water has been one of the greatest public health successes. Numerous halogenated disinfection by-products (DBPs) occur and chronic ingestion has been associated with an increased risk for colorectal cancer in human populations. Because the intestinal microbiota can bioactivate xenobiotics, stu...

journal_title：Cancer letters

authors： George SE,Wolf DC,Brooks LR,Bailey KC,Hooth MJ,Nelson GM

更新日期：2004-02-10 00:00:00

abstract：:Carbaryl (1-naphthyl methyl carbamate: C12H11NO2) CAS Reg. No. 63-25-2) is a widely used broad spectrum carbamate insecticide known to exert various toxic effects on experimental animals. Along with various other toxicological effects carbaryl is reported to increase the incidence of neoplasm in various tissues in rat...

journal_title：Cancer letters

authors： Shukla Y,Antony M,Mehrotra NK

更新日期：1992-02-29 00:00:00

abstract：:The emerging roles of integrin β3 in the epithelial-mesenchymal transition (EMT) and drug resistance underline its significance in cancer metastasis and recurrence. However, the molecular mechanism underlying the distinctive expression of integrin β3 is less understood. In the present report, we demonstrated that repe...

journal_title：Cancer letters

authors： Hong SK,Park JR,Kwon OS,Kim KT,Bae GY,Cha HJ

更新日期：2016-07-01 00:00:00

abstract：:Electron microscopic studies were made on an in vitro cultured cell line obtained from the FCB transplantable murine bladder tumour. The cells exhibited a loss of differentiation compared with solid tumour and the presence of C-type virus particles, many in the process of budding. The possible relation of this virus t...

journal_title：Cancer letters

authors： Flaks A

更新日期：1977-07-01 00:00:00

abstract：:Microtubule targeting based therapies have revolutionized cancer treatment; however, resistance and side effects remain a major limitation. Therefore, novel strategies that can overcome these limitations are urgently needed. We made a novel discovery that fisetin, a hydroxyflavone, is a microtubule stabilizing agent. ...

journal_title：Cancer letters

authors： Mukhtar E,Adhami VM,Sechi M,Mukhtar H

更新日期：2015-10-28 00:00:00

abstract：:Dysregulation of circular RNA Foxo3 (circFoxo3) has been reported to be involved in breast cancer and non-small lung cancer progression. However, little is known about the role of circFoxo3 in prostate cancer, which the present study seeks to investigate. CircFoxo3 expression was analyzed in 22 low-grade prostate canc...

journal_title：Cancer letters

authors： Shen Z,Zhou L,Zhang C,Xu J

更新日期：2020-01-01 00:00:00

abstract：:The effect of the naturally occurring flavonol, quercetin, was investigated on cell growth and metabolism of two human carcinoma cell lines, HT29 and Caco-2 cells, both during the exponentially growing phase and after confluence. Our results show clearly that, after a 48-h period of treatment, quercetin (in the range ...

journal_title：Cancer letters

authors： Agullo G,Gamet L,Besson C,Demigné C,Rémésy C

更新日期：1994-11-25 00:00:00

abstract：:The RB-E2F1 pathway is an important mechanism of cell-cycle control, and deregulation of this pathway is one of the key factors contributing to tumorigenesis. Cyclin-dependent kinases (CDKs) and Cyclin D have been known to increase in aggressive thyroid cancer. However, there has been no study to investigate effects o...

journal_title：Cancer letters

authors： Lee HJ,Lee WK,Kang CW,Ku CR,Cho YH,Lee EJ

更新日期：2018-03-28 00:00:00

abstract：:Herein we report a method for studying slow acting pharmaceutical COX-2 inhibitors in the MCF-7 breast cancer cell line where cells are grown in a three-dimensional format within an agarose matrix. The cancer cells are suspended in agarose and plated in a cell culture dish, where they will form small multicellular 'tu...

journal_title：Cancer letters

authors： Kinder DH,Aulthouse AL

更新日期：2004-03-08 00:00:00

abstract：:In experimental cancer chemoprevention studies, the doses of the agent used to produce an inhibitory response are generally very high, sometimes bordering on levels that will result in toxicity to the test animals. The present study was designed to test the hypothesis that low doses of two or more agents may be just a...

journal_title：Cancer letters

authors： Ip C

更新日期：1988-04-01 00:00:00

abstract：:We have used human procathepsin D isolated from supernatant of human breast cancer cell line ZR-75-1 to test its mitogenic activity for a broad spectrum of human-derived cell lines. These cell lines included: breast cancer cell lines ZR-75-1, MDA-MB-436, MBA-MD-483 and MDA-MB-231, B lymphoblastoid cell line Raji, the ...

journal_title：Cancer letters

authors： Vĕtvicka V,Vĕktvicková J,Fusek M

更新日期：1994-05-16 00:00:00

abstract：:Many studies have shown that the activation of beta-catenin signaling can promote oncogenesis, and it is therefore of interest to find agents that modulate this pathway. Recent work has shown using B lymphoma cells that infection by Epstein-Barr virus (EBV) and expression of its latent membrane protein (LMP)-1, cause ...

journal_title：Cancer letters

authors： Min HJ,Cho IR,Srisuttee R,Park EH,Cho DH,Ahn JH,Lee IS,Johnston RN,Oh S,Chung YH

更新日期：2009-04-18 00:00:00

abstract：:The B cell lymphomas associated with Epstein-Barr virus (EBV) are not limited to any specific stage of B cell differentiation but covers widely different B cell phenotypes. In vitro infection of the virus negative tumors with a recombinant EBV strain has provided important insights into virus-tumor interaction. Here, ...

journal_title：Cancer letters

authors： Anastasiadou E,Vaeth S,Cuomo L,Boccellato F,Vincenti S,Cirone M,Presutti C,Junker S,Winberg G,Frati L,Wade PA,Faggioni A,Trivedi P

更新日期：2009-11-01 00:00:00

abstract：:Poly(ADP-ribose) synthetase activity in human cervical cancer cell nuclei was found to be approximately twice that of normal cervical cell nuclei. Using antipoly(ADP-ribose) antibody, frozen section of normal tissue were stained by indirect-immunofluorescence and it was demonstrated that the fluorescence of nuclei in ...

journal_title：Cancer letters

authors： Fukushima M,Kuzuya K,Ota K,Ikai K

更新日期：1981-12-01 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) is one of the most malignant tumors in Southern China and southeast Asia, which is characterized by a dense lymphocyte infiltration and a poor prognosis. The emergence of single-cell sequencing represents a powerful tool to resolve tumor heterogeneity and delineate the complex communicat...

journal_title：Cancer letters

authors： Zhao J,Guo C,Xiong F,Yu J,Ge J,Wang H,Liao Q,Zhou Y,Gong Q,Xiang B,Zhou M,Li X,Li G,Xiong W,Fang J,Zeng Z

更新日期：2020-05-01 00:00:00

abstract：:Oral squamous cell carcinoma (OSCC) is a characteristic locally aggressive tumor in which hypoxia levels are very high, causing a low response to chemotherapy and providing basic resistance to anticancer drugs. Tumoral hypoxia directly depends on hypoxia-inducible factors (HIF). The goal of this paper is to describe H...

journal_title：Cancer letters

authors： Pérez-Sayáns M,Suárez-Peñaranda JM,Pilar GD,Barros-Angueira F,Gándara-Rey JM,García-García A

更新日期：2011-12-26 00:00:00

abstract：:To understand the role of cyclooxygenase-2 (COX-2) in gastric cancer, we examined the abundance of COX-2, vascular endothelial growth factor-A (VEGF-A), and CD34 in 45 surgically resected human gastric cancers and paired normal gastric mucosa by immunohistochemical analysis. In addition, the message RNA (mRNA) express...

journal_title：Cancer letters

authors： Yu HG,Li JY,Yang YN,Luo HS,Yu JP,Meier JJ,Schrader H,Bastian A,Schmidt WE,Schmitz F

更新日期：2003-05-30 00:00:00

abstract：:Neuroendocrine (carcinoid) tumours of the thymus are rare neoplasms characterized by a highly malignant clinical behavior. Some of these tumors are associated with MEN1. In this study we evaluated 10 cases of sporadic thymic neuroendocrine tumours using immunohistochemistry and comparative genomic hybridization (CGH)....

journal_title：Cancer letters

authors： Rieker RJ,Aulmann S,Penzel R,Schnabel PA,Blaeker H,Esposito I,Morresi-Hauf A,Otto HF,Hecker E,Dienemann H,Schirmacher P,Mechtersheimer G

更新日期：2005-06-01 00:00:00

abstract：:The induction of differentiation of SENCAR murine granulocyte-macrophage precursor cells (GM-CFU) by the tumor-promoting phorbol diester 12-O--tetradecanoyl-phorbol-13-acetate (TPA) was inhibited by agents reported to inhibit specific aspects of arachidonic acid metabolism. These agents included phospholipase A2 inhib...

journal_title：Cancer letters

authors： Baxter CS,Lawrence AT

更新日期：1987-11-01 00:00:00

abstract：:One of the most promising substances used in photodynamic therapy (PDT) is 5-aminolevulinic acid (ALA), which induces endogenous synthesis and accumulation of porphyrins in malignant cells. In this paper we have shown that both topical and intratumoral administration of ALA in a subcutaneously implanted mammary carcin...

journal_title：Cancer letters

authors： Casas A,Fukuda H,Meiss R,Batlle AM

更新日期：1999-07-01 00:00:00

abstract：:The chemokine CXCL12 (SDF-1) and its receptor, CXCR4, have been implicated in organ-specific metastases of several malignancies. Head and neck squamous cell carcinoma (HNSCC) predominantly metastasizes to lymph nodes, and recent evidence has shown that CXCL12 stimulates HNSCC migration. We explored the potential role ...

journal_title：Cancer letters

authors： Samara GJ,Lawrence DM,Chiarelli CJ,Valentino MD,Lyubsky S,Zucker S,Vaday GG

更新日期：2004-10-28 00:00:00

abstract：:Sulofenur treatment (12.5 microM-1 mM) of colon adenocarcinoma cell lines resulted in dose- and time-dependent cell killing. LYc5 cells were viable longer than GC3/c1 cells. Each concentration resulted in elevation of cytosolic calcium [Ca2+]i) for both cell lines. At lower doses, elevation was delayed for LYc5 cells....

journal_title：Cancer letters

authors： Phelps PC,Jain PT,Berezesky IK,Boder GB,Trump BF

更新日期：1995-01-06 00:00:00

abstract：:Calcium/calmodulin-dependent kinase (CaMK) I and II expression in endometrial cancer cells correlates with the malignant potential of this tumor, and CaMKI and II are potential therapeutic targets in endometrial cancer. CaMKI and II expression was significantly associated with PCNA-labeling index, clinical stage, hist...

journal_title：Cancer letters

authors： Takai N,Ueda T,Nasu K,Yamashita S,Toyofuku M,Narahara H

更新日期：2009-05-18 00:00:00

abstract：:The mutagenicity of a non-carcinogenic nitrosamine, N,N-dibenzylnitrosamine (I), and a chemically synthesized alpha-acetoxy derivative, N-(alpha-acetoxy-benzyl)-N-benzylnitrosamine (II), has been examined in Salmonella typhimurium TA100 and TA1535. Compound (I) was non-mutagenic when tested directly or in the presence...

journal_title：Cancer letters

authors： Jacobson MK,Barton RA,Yoder SS,Sigh S,Lyle RE

更新日期：1979-02-01 00:00:00