Dietary flavonoid fisetin binds to β-tubulin and disrupts microtubule dynamics in prostate cancer cells.

abstract：:Cell-adhesive protein laminin and its specific receptor play an important role in the processes of cancer proliferation, invasion and metastasis. In the present study, we cloned the cDNAs of the 67-kDa laminin receptor both from a human lung cell line (IMR90) and from a human lung cancer cell line (SBC3), and determin...

journal_title：Cancer letters

authors： Satoh K,Narumi K,Sakai T,Abe T,Kikuchi T,Matsushima K,Sindoh S,Motomiya M

更新日期：1992-03-15 00:00:00

abstract：:Human epidermal growth factor receptor 2 (HER2), a member of the HER family of tyrosine kinases and a binding partner of Heat shock protein 90 (Hsp90), is found amplifies in approximately 25% breast cancers. Treatment of HER2+ breast cancers has been greatly improved in recent years, but the accompanying upregulation ...

journal_title：Cancer letters

authors： Huang W,Wu QD,Zhang M,Kong YL,Cao PR,Zheng W,Xu JH,Ye M

更新日期：2015-01-28 00:00:00

abstract：:Sulforaphane (SFN) is an isothiocyanate found in cruciferous vegetables, with particularly high levels detected in broccoli and broccoli sprouts. Over a decade ago, this phytochemical was identified as a likely chemopreventive agent based on its ability to induce Phase 2 detoxification enzymes, as well as to inhibit P...

journal_title：Cancer letters

authors： Myzak MC,Dashwood RH

更新日期：2006-02-28 00:00:00

abstract：:The ability to recognize and respond to universal molecular patterns on invading microorganisms allows our immune system to stay on high alert, sensing danger to our self-integrity. Our own damaged cells and tissues in pathological situations activate similar warning systems as microbes. In this way, the body is able ...

journal_title：Cancer letters

authors： Ratikan JA,Micewicz ED,Xie MW,Schaue D

更新日期：2015-11-28 00:00:00

abstract：:The polymorphism in the ALDH2 gene plays a central role in Asian alcohol hypersensitivity and has been associated with the risk for esophageal cancer. In the present study, we attempted to examine associations between the ADH2 and ALDH2 polymorphisms, alcohol drinking and hepatocellular carcinoma (HCC) development in ...

journal_title：Cancer letters

authors： Takeshita T,Yang X,Inoue Y,Sato S,Morimoto K

更新日期：2000-02-28 00:00:00

abstract：:The capacity of enteric bacteria (E. coli, Salmonella, Pseudomonas, Shigella and Klebsiella) to catalyze the covalent binding of benzo(a)pyrene (BP), cholic acid, deoxycholic acid and cholesterol was investigated. In general, these bacteria were incapable of activating BP to a covalently bound product with calf thymus...

journal_title：Cancer letters

authors： Zachariah PK,Slaga TJ,Berry DL,Bracken WM,Buty SG,Martinsen CM,Juchau MR

更新日期：1977-07-01 00:00:00

abstract：:To clarify the roles of Bmi-1 in colorectal carcinoma, we examined the expression of Bmi-1 in 41 samples out of 46 colorectal carcinomas by reverse transcription-PCR, whereas all 46 were analyzed by immunostaining. In addition, we analyzed the expression patterns of Bmi-1 in association with p16INK4a and p14ARF (in mo...

journal_title：Cancer letters

authors： Kim JH,Yoon SY,Kim CN,Joo JH,Moon SK,Choe IS,Choe YK,Kim JW

更新日期：2004-01-20 00:00:00

abstract：:Anticancer properties of chemically synthesized compounds have continuously been optimized for better efficacy and selectivity. Derivatives of heterocyclic compounds are well known to have selective antiproliferative effect against many types of cancer. In this study, we investigated the ability of an indigenously syn...

journal_title：Cancer letters

authors： Saleh AM,Taha MO,Aziz MA,Al-Qudah MA,AbuTayeh RF,Rizvi SA

更新日期：2016-06-01 00:00:00

abstract：:Inclusion of 10% ethanol with 6.8 ppm N-nitrosodiethylamine in the drinking water of strain A male mice resulted in a 4-fold enhancement of multiplicity of lung tumors and a 16-fold increase in incidence of fore-stomach tumors, compared with carcinogen alone. Given with 40 ppm N-nitrosopyrrolidine, ethanol caused a 5....

journal_title：Cancer letters

authors： Anderson LM,Carter JP,Driver CL,Logsdon DL,Kovatch RM,Giner-Sorolla A

更新日期：1993-01-15 00:00:00

abstract：:To be capable of selective killing of tumor cells, the non-selective Pseudomonas aeruginosa exotoxin A must have its cell-binding domain inactivated or removed and then be chemically linked to, or genetically fused with, a specific targeting agent. In the present study, epsilon-NH2 groups of lysine residues of the cel...

journal_title：Cancer letters

authors： Bourdenet S,Doyonnas R,Vacheron MJ,Guinand M,Fasciotto B,Ristic A,Michel G,Cozzone AJ,Durkin JP,Whitfield JF

更新日期：1990-04-20 00:00:00

abstract：:The development of multidrug resistance (MDR) to chemotherapy remains a major challenge in the treatment of cancer. Numerous mechanisms have been recognized that cause MDR, but one of the most important mechanisms is overexpression of adenosine triphosphate (ATP)-binding cassette (ABC) transporters, through which the ...

journal_title：Cancer letters

authors： Fan YF,Zhang W,Zeng L,Lei ZN,Cai CY,Gupta P,Yang DH,Cui Q,Qin ZD,Chen ZS,Trombetta LD

更新日期：2018-05-01 00:00:00

abstract：:To determine the genotoxic risk associated with therapeutic exposure to 131I, we studied the presence of micronuclei (MN) in binucleated peripheral blood lymphocytes of a group of 22 women, patients of thyroid cancer, who received 131I sodium iodide orally as an adjuvant after total thyroidectomy. The cytogenetic stud...

journal_title：Cancer letters

authors： Gutiérrez S,Carbonell E,Galofréa P,Xamena N,Creus A,Marcos R

更新日期：1995-05-08 00:00:00

abstract：:The effects of carotenoids--alpha-carotene, beta-carotene, lycopene, beta-cryptoxanthin, zeaxanthin, lutein, canthaxanthin, astaxanthin--on the invasion of rat ascites hepatoma AH109A cells were investigated by co-culturing the hepatoma cells with rat mesentery-derived mesothelial cells (M-cells). All the carotenoids ...

journal_title：Cancer letters

authors： Kozuki Y,Miura Y,Yagasaki K

更新日期：2000-04-03 00:00:00

abstract：:Mutations of Ki-ras and p53 genes in hepatocellular carcinomas (HCCs) induced by the choline deficient L-amino acid defined (CDAA) diet in rats were investigated by polymerase chain reaction (PCR), single strand conformation polymorphism (SSCP) analysis followed by direct sequencing. Male Fischer 344 rats, 6 weeks old...

journal_title：Cancer letters

authors： Tsujiuchi T,Kido A,Nakae D,Takahama M,Majima T,Kobitsu K,Okajima E,Tsutsumi M,Denda A,Konishi Y

更新日期：1996-11-12 00:00:00

abstract：:Ibrutinib, an inhibitor of Bruton tyrosine kinase (BTK), has shown promising pharmacologic effects in acute myeloid leukemia (AML). In this study, we report that abivertinib or AC0010, a novel BTK inhibitor, inhibits cell proliferation, reduces colony-forming capacity, and induces apoptosis and cell cycle arrest in AM...

journal_title：Cancer letters

authors： Huang S,Pan J,Jin J,Li C,Li X,Huang J,Huang X,Yan X,Li F,Yu M,Hu C,Jin J,Xu Y,Ling Q,Ye W,Wang Y,Jin J

更新日期：2019-10-01 00:00:00

abstract：:Innate resistance to various therapeutic interventions is a hallmark of cancer. In recent years, however, acquired resistance has emerged as a daunting challenge to anticancer treatments including chemotherapy, radiation and targeted therapy, which abolishes the efficacy of otherwise successful regimens. Cancer cells ...

journal_title：Cancer letters

authors： Sun Y

更新日期：2016-09-28 00:00:00

abstract：:We reported that poor prognoses of hepatocellular carcinoma (HCC) patients after radiofrequency ablation (RFA) are owing to up-regulation of expression of hypoxia-inducible factor-1 and epithelial cell adhesion molecule. We investigated aggressive progression in residual liver tumors (RLTs) after RFA to focus on expre...

journal_title：Cancer letters

authors： Iwahashi S,Shimada M,Utsunomiya T,Imura S,Morine Y,Ikemoto T,Takasu C,Saito Y,Yamada S

更新日期：2016-05-28 00:00:00

abstract：:Effects of cis-dichlorodiammineplatinum-(II) (cis-DDP), an anticancer agent, on capping of membrane receptors were investigated in mouse spleen cells in vitro, using fluorescein labeled ligands. Cap formations of surface immunoglobulin and of concanavalin A receptors were significantly reduced by cis-DDP in relation t...

journal_title：Cancer letters

authors： Tsokos GC,Choie DD

更新日期：1980-09-01 00:00:00

abstract：:One of the 2 main components of the commercially available carcinogenic aristolochic acid (AA) was isolated, the other was enriched. Three different aristolochic acid samples (AAI 99% pure; AAI 65% + AAII 35%; AAI 32% + AAII 68%) were assayed for mutagenic activity in Salmonella typhimurium TA1537, TA100 and TA100 NR ...

journal_title：Cancer letters

authors： Schmeiser HH,Pool BL,Wiessler M

更新日期：1984-05-01 00:00:00

abstract：:Mice with hereditary intestinal polyposis have mutations of the APC gene which causes formation of multiple polyps. At least one other gene influences the susceptibility for development of polyps in mice, and the locus was named Mom1. The causative gene for the Mom1 locus has recently been cloned and was found to be i...

journal_title：Cancer letters

authors： Kawamata N,Seriu T,Bartram CR,Koeffler HP

更新日期：1997-01-01 00:00:00

abstract：:We previously reported that prostaglandin E(2) contributes to colon carcinogenesis through its binding to the prostaglandin E receptor subtype EP(1) using a genetic approach in EP(1)-knockout mice and a pharmacological approach with the EP(1) selective antagonist, ONO-8711. In the present study, we examined the effect...

journal_title：Cancer letters

authors： Watanabe K,Kawamori T,Nakatsugi S,Ohta T,Ohuchida S,Yamamoto H,Maruyama T,Kondo K,Narumiya S,Sugimura T,Wakabayashi K

更新日期：2000-08-01 00:00:00

abstract：:We studied the effect of staurosporine (SSP), a broad-spectrum protein kinase inhibitor, on the levels of protein kinase C (PKC) activity and proliferation in two murine neuroblastoma cell lines, Neuro2a and its clone NB41A3. The PKC activity was examined in whole cell lysate, cytosolic and particulate fractions. A di...

journal_title：Cancer letters

authors： Mohan DR,Nagarathna R,Krishna M,Jagtap JC,Shastry P

更新日期：1999-05-24 00:00:00

abstract：:The vectors PAI2, C595 and Herceptin target the membrane-bound uPA, MUC1 and HER2 antigens expressed by cancer cells, respectively. The expression of these receptors was tested in the ovarian cancer cell line OVCAR-3; MUC-1 was strongly expressed (3+), uPA moderately expressed (2+), but HER2 was negative (-). The alph...

journal_title：Cancer letters

authors： Song YJ,Qu CF,Rizvi SM,Li Y,Robertson G,Raja C,Morgenstern A,Apostolidis C,Perkins AC,Allen BJ

更新日期：2006-03-28 00:00:00

abstract：:Tumor tissues are chronically exposed to hypoxia owing to aberrant vascularity. Hypoxia induces metabolic alterations in cancer, thereby promoting aggressive malignancy and metastasis. While previous efforts largely focused on adaptive responses in glucose and glutamine metabolism, recent studies have begun to yield i...

journal_title：Cancer letters

authors： Povero D,Johnson SM,Liu J

更新日期：2020-11-28 00:00:00

abstract：:Integrin cell adhesion molecules play a crucial role in tumor cell resistance to radio- and chemotherapy and are therefore considered attractive targets for cancer therapy. Here, we assessed the role of β1 integrin-interacting α integrin subunits in more physiological three-dimensional extracellular matrix grown head ...

journal_title：Cancer letters

authors： Steglich A,Vehlow A,Eke I,Cordes N

更新日期：2015-02-28 00:00:00

abstract：:The promoting potential of oxymetholone (OXM) administration on development of liver cell foci was investigated in male F344 rats previously treated with N-diethylnitrosamine (DEN). One week after a single injection of DEN (100 mg/kg, i.p.), rats were given OXM at a dietary level of 0.2% for the first 4 weeks and then...

journal_title：Cancer letters

authors： Shimoji N,Imaida K,Hasegawa R,Matsuoka C,Uneyama CT,Takahashi M,Hayashi Y

更新日期：1990-02-01 00:00:00

abstract：:The mutagenicity of a non-carcinogenic nitrosamine, N,N-dibenzylnitrosamine (I), and a chemically synthesized alpha-acetoxy derivative, N-(alpha-acetoxy-benzyl)-N-benzylnitrosamine (II), has been examined in Salmonella typhimurium TA100 and TA1535. Compound (I) was non-mutagenic when tested directly or in the presence...

journal_title：Cancer letters

authors： Jacobson MK,Barton RA,Yoder SS,Sigh S,Lyle RE

更新日期：1979-02-01 00:00:00

abstract：:In continuation of our studies of natural and synthetic products as cancer chemopreventive agents, we have examined a number of naphthoquinone derivatives including monomeric, dimeric and tetrameric naphthaquinones occurring in the Diospyros and other selected plant genera. Several synthetic naphthoquinones were also ...

journal_title：Cancer letters

authors： Kapadia GJ,Balasubramanian V,Tokuda H,Konoshima T,Takasaki M,Koyama J,Tagahaya K,Nishino H

更新日期：1997-02-26 00:00:00

abstract：:Because lipoperoxides seem able to modulate tumor growth, we have examined the concomitant effects of dietary antioxidant (vitamin E) and of a high amount of polyunsaturated fatty acids (PUFA) in a model of chemically-induced mammary carcinogenesis. Two groups of rats received a high fat diet with or without added vit...

journal_title：Cancer letters

authors： Lhuillery C,Cognault S,Germain E,Jourdan ML,Bougnoux P

更新日期：1997-03-19 00:00:00

abstract：:We generated three anti-ErbB-2 monoclonal antibodies (mAbs) by using surface-epitope masking method (SEM method). They were characterized and shown to recognize the extracellular domain (ECD) of ErbB-2 specifically. In order to detect ErbB-2 in the sera of breast cancer patients, we used two of them: A18 and A21 to de...

journal_title：Cancer letters

authors： Li P,Li Y,Li JY,Liu J

更新日期：2003-04-25 00:00:00