Inhibitory effect of a prostaglandin E receptor subtype EP(1) selective antagonist, ONO-8713, on development of azoxymethane-induced aberrant crypt foci in mice.

abstract：:To search for possible cancer chemopreventive agents from natural sources, we performed primary screening of ten flavanones isolated from plants belonging to Rutaceae and Leguminosae by examining their possible inhibitory effects on Epstein-Barr virus (EBV) early antigen activation induced by 12-O-tetradecanoylphorbol...

journal_title：Cancer letters

authors： Itoigawa M,Ito C,Ju-ichi M,Nobukuni T,Ichiishi E,Tokuda H,Nishino H,Furukawa H

更新日期：2002-02-08 00:00:00

abstract：:V600E being the most common mutation in BRAF, leads to constitutive activation of the MAPK signaling pathway. The majority of V600E BRAF positive melanoma patients treated with the BRAF inhibitor vemurafenib showed initial good clinical responses but relapsed due to acquired resistance to the drug. The aim of the pres...

journal_title：Cancer letters

authors： Zubrilov I,Sagi-Assif O,Izraely S,Meshel T,Ben-Menahem S,Ginat R,Pasmanik-Chor M,Nahmias C,Couraud PO,Hoon DS,Witz IP

更新日期：2015-05-28 00:00:00

abstract：:High doses of folate and its quinazoline analogue with antitumour activity, N10-propargyl-5,8-dideazafolic acid (CB 3717), caused severe renal damage in mice, leading in the case of folate to death. The mouse kidneys increased in weight, which was accompanied by time- and dose-dependent induction of ornithine decarbox...

journal_title：Cancer letters

authors： Manteuffel-Cymborowska M,Chmurzyńska W,Grzelakowska-Sztabert B

更新日期：1991-09-01 00:00:00

abstract：:The identification of frameshift mutations in the coding region of the bax gene in Western cases of hereditary non-polyposis colorectal cancer provided evidence that the disease could be caused by the disruption of a tumor suppressor gene associated with microsatellite instability. In order to determine whether this o...

journal_title：Cancer letters

authors： Sakakibara T,Nakamura T,Yamamoto M,Matsuo M

更新日期：1998-02-27 00:00:00

abstract：:D-501036 is a promising anti-cancer compound that exhibits potent anti-proliferative activity against various types of human cancers through the induction of double strand DNA breaks. To determine drug resistance mechanism related to this class of DNA-damaging agents, a KB-derived D-501036-resistant cell line (S4) was...

journal_title：Cancer letters

authors： Yang YN,Chou KM,Pan WY,Chen YW,Tsou TC,Yeh SC,Cheung CH,Chen LT,Chang JY

更新日期：2011-10-01 00:00:00

abstract：:Sprague-Dawley rats were injected weekly with either 1,2-dimethylhydrazine (DMH) or methylazoxymethanol acetate (MAM). Addition of 4 ppm selenium (sodium selenite) in the drinking water reduced the number of rats developing DMH-induced colon tumors from 13 to 6 groups of 15 each. The total number of tumors observed in...

journal_title：Cancer letters

authors： Jacobs MM,Jansson B,Griffin AC

更新日期：1977-01-01 00:00:00

abstract：:An emerging trend in cancer chemoimmunotherapeutics is to develop 'two-in-one' therapies, which directly inhibit tumor growth and progression, as well as enhance anti-tumor immune surveillance. Protein kinase A (PKA) is a cAMP-dependent protein kinase that mediates signal transduction of G-protein coupled receptors (G...

journal_title：Cancer letters

authors： Hussain M,Tang F,Liu J,Zhang J,Javeed A

更新日期：2015-12-01 00:00:00

abstract：:Enhanced expression of the nucleotide excision repair gene XPA is associated with resistance to cisplatin treatment in human ovarian cancer. Understanding the cause of enhanced XPA expression will provide new molecular targets for therapy directed at overcoming chemoresistance. Enhanced gene expression in cancer cells...

journal_title：Cancer letters

authors： States JC,Reed E

更新日期：1996-11-29 00:00:00

abstract：:The basic fraction of tryptophan pyrolysis products (TBF) showed strong mutagenic activity on somatic cells of the lung of Chinese hamsters. In this somatic mutation test, TBF was demonstrated to have 5.6 times higher mutagenicity than diethylnitrosamine (DEN) when mutants were selected with 8-azaguanine, and 13.5-fol...

journal_title：Cancer letters

authors： Inui N,Nishi Y,Hasegawa MM,Kawachi T

更新日期：1980-05-01 00:00:00

abstract：:It has been nearly 9years since the FDA (Food and Drug Administration) approved the first anti-angiogenic drug (bevacizumab) for treatment of metastatic colorectal cancer. Other angiogenic inhibitors have since been approved or are in different stages of clinical trials. However, continued clinical and preclinical inv...

journal_title：Cancer letters

authors： Shojaei F

更新日期：2012-07-28 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are the first type of stem cells to be utilized in clinical regenerative medicine, mainly owing to their capacity for multipotent differentiation and the feasibility of autologous transplantation. More recently, the specific tumor-oriented migration and incorporation of MSCs have been dem...

journal_title：Cancer letters

authors： Dai LJ,Moniri MR,Zeng ZR,Zhou JX,Rayat J,Warnock GL

更新日期：2011-06-01 00:00:00

abstract：:The regulator of G protein signaling 10 (RGS10) protein is a GTPase activating protein that accelerates the hydrolysis of GTP and therefore canonically inactivates G proteins, ultimately terminating signaling. Rheb is a small GTPase protein that shuttles between its GDP- and GTP-bound forms to activate mTOR. Since RGS...

journal_title：Cancer letters

authors： Altman MK,Alshamrani AA,Jia W,Nguyen HT,Fambrough JM,Tran SK,Patel MB,Hoseinzadeh P,Beedle AM,Murph MM

更新日期：2015-12-01 00:00:00

abstract：:Interferon induced transmembrane protein 1 (IFITM1) belongs to a family of interferon stimulated genes (ISGs) that is associated with tumor progression and DNA damage resistance; however, its role in endocrine resistance is not known. Here, we correlate IFITM1 expression with clinical stage and poor response to endocr...

journal_title：Cancer letters

authors： Lui AJ,Geanes ES,Ogony J,Behbod F,Marquess J,Valdez K,Jewell W,Tawfik O,Lewis-Wambi J

更新日期：2017-07-28 00:00:00

abstract：:Many clinical studies have shown that circulating RNA rises in cancer patients, but little is known about the origins of abnormally elevated extracellular RNA (exRNA). We designed four different culture conditions: serum-deprived, hypoxia, low temperature and exposure to an anticancer drug to investigate the origins i...

journal_title：Cancer letters

authors： Zhou H,Xu W,Qian H,Yin Q,Zhu W,Yan Y

更新日期：2008-01-18 00:00:00

abstract：:Midkine (MK) is a heparin binding growth factor identified as a product of a retinoic acid-responsive gene; it is frequently expressed at high levels in many human carcinomas. Although the expression of the mRNA encoding truncated MK (tMK) in unique human cancer cells has been reported, the tMK polypeptide itself has ...

journal_title：Cancer letters

authors： Paul S,Mitsumoto T,Yamamoto I,Shinozawa T

更新日期：2001-02-26 00:00:00

abstract：:Staurosporine and its derivative 7-hydroxystaurosporine are protein kinase inhibitors that are being considered for treatments of cancers. Several recent studies have shown that cells with defective pRB protein are resistant to the G(1) cell cycle-inhibiting effects of staurosporine compounds. In this study, we examin...

journal_title：Cancer letters

authors： Zhou W,Lin Y,Wersto R,Chrest J,Gabrielson E

更新日期：2002-09-08 00:00:00

abstract：:Human hepatoma Hep 3B cells underwent apoptosis in response to 100 microM all-trans retinoic acid (RA) in full serum (10% fetal calf serum) condition in vitro. Cell death began approximately 24 h following treatment, with more than 80% of the cells dead after 60 h. The dead cells, mainly detached cells, exhibited cond...

journal_title：Cancer letters

authors： Kim DG,Jo BH,You KR,Ahn DS

更新日期：1996-10-01 00:00:00

abstract：:Glucocorticoids (GCs) are pro-apoptotic as a co-medication to treat leukemia and lymphoma. However, the effects in breast cancer (BC) are diverse with mechanisms less understood. In this study using BC model cell MCF7, we found that dexamethasone (Dex) promotes cell proliferation. Gene expression analysis identified t...

journal_title：Cancer letters

authors： Khan S,Lopez-Dee Z,Kumar R,Ling J

更新日期：2013-08-28 00:00:00

abstract：:Fifteen samples from 11 patients suffering from chronic lymphocytic leukaemia (CLL; 5 untreated, 6 chemotherapeutically treated) were analysed for their individual gene expression of the multidrug resistance (MDR) associated genes encoding mdr1/P-glycoprotein, mrp, and topoisomerase II alpha/beta-isoenzymes by a compl...

journal_title：Cancer letters

authors： Beck J,Niethammer D,Gekeler V

更新日期：1994-10-28 00:00:00

abstract：:Myosin light-chain kinase (MLCK) plays a crucial role in the cell migration and tumor metastasis. Herein, we investigated the signaling pathways involved in MLCK using ML-7, a specific inhibitor of MLCK, in breast cancer cell proliferation and migration. Our data showed that reduction of MLCK in breast cancer cells me...

journal_title：Cancer letters

authors： Zhou X,Liu Y,You J,Zhang H,Zhang X,Ye L

更新日期：2008-11-08 00:00:00

abstract：:This study investigated the relationship between clinicopathological or immunohistochemical factors and postoperative prognosis for Dukes' C colorectal cancer. Short-term survivors died from cancer within 2 years of surgery, whereas long-term survivors were disease-free for over 10 years. The groups differed in Ki-67 ...

journal_title：Cancer letters

authors： Ishida H,Miwa H,Tatsuta M,Masutani S,Imamura H,Shimizu J,Ezumi K,Kato H,Kawasaki T,Furukawa H,Kawakami H

更新日期：2004-04-15 00:00:00

abstract：:The mdm2 oncogene is amplified and overexpressed in a variety of human tumours and the oncogenic potential of MDM2 is partly due to its ability to inactivate tumour suppressor p53 function. In the present communication we describe the cloning, sequence analysis and expression of the complete wildtype canine and equine...

journal_title：Cancer letters

authors： Nasir L,Burr PD,McFarlane ST,Gault E,Thompson H,Argyle DJ

更新日期：2000-04-28 00:00:00

abstract：:The quality and frequency of mutations in PTEN gene were assessed in 59 carcinomas and 6 hyperplasias of the endometrium in women. Screening for mutations was done in all exons of PTEN gene by the PCR-SSCP analysis and DNA sequencing. Results were correlated with histological status and clinical features of endometria...

journal_title：Cancer letters

authors： Konopka B,Paszko Z,Janiec-Jankowska A,Goluda M

更新日期：2002-04-08 00:00:00

abstract：:Currently, animal models are used to test the efficacy of tumor treatment. A significant reduction of tumor mass is lauded as great improvement. As we begin the 21st century, one wonders if this is sufficient and acceptable for cancer treatment. Although the presence of cancer stem cell (CSCs) is not a new phenomenon,...

journal_title：Cancer letters

authors： Nahas G,Bliss SA,Sinha G,Ganta T,Greco SJ,Rameshwar P

更新日期：2015-01-28 00:00:00

abstract：:Treatment resistance in acute lymphoblastic leukemia (ALL) is often caused by defects in programmed cell death, e.g. by overexpression of Inhibitor of Apoptosis (IAP) proteins. Here, we report that small-molecule Smac mimetics (i.e. BV6, LCL161, birinapant) that neutralize x-linked IAP (XIAP), cellular IAP (cIAP)1 and...

journal_title：Cancer letters

authors： Gerges S,Rohde K,Fulda S

更新日期：2016-05-28 00:00:00

abstract：:Increased intramedullary apoptotic death of hematopoietic cells is thought to contribute to the ineffective hematopoiesis in myelodysplastic syndromes (MDS). Furthermore, high amounts of tumor necrosis factor alpha (TNF alpha) have previously been correlated with apoptosis in MDS marrows. The present studies were unde...

journal_title：Cancer letters

authors： Mundle SD,Reza S,Ali A,Mativi Y,Shetty V,Venugopal P,Gregory SA,Raza A

更新日期：1999-06-01 00:00:00

abstract：:To investigate the monoclonality of hepatocellular carcinoma (HCC) and dysplastic nodule (DN) and the origin of multiple lesions, patterns of inactivation of X-linked human androgen receptor gene were studied. Fourteen of 15 patients (93%) were heterozygous in the size of the target, and were informative for clonal an...

journal_title：Cancer letters

authors： Okuda T,Wakasa K,Kubo S,Hamada T,Fujita M,Enomoto T,Haba T,Hirohashi K,Kinoshita H

更新日期：2001-03-10 00:00:00

abstract：:Genomic instability is characteristic of malignant cells, and a strong correlation exists between abnormal karyotype and tumorigenicity. Increased expression of the homologous recombination and DNA repair protein Rad51 has been reported in immortalized cell lines and multiple primary tumor cell types which could alter...

journal_title：Cancer letters

authors： Richardson C

更新日期：2005-02-10 00:00:00

abstract：:Application of functional imaging to radiotherapy (RT) is a rapidly expanding field with the development of new modalities and techniques. Functional imaging of PET in conjunction with RT provides new avenues towards the clinical application of dose painting - a new RT strategy delivering optimized dose redistribution...

journal_title：Cancer letters

authors： Shi X,Meng X,Sun X,Xing L,Yu J

更新日期：2014-12-28 00:00:00

abstract：:The intracellular concentrations of adenosine 3',5'-cyclic monophosphate (cAMP) in colonic tumors induced in adult male Holtzman rats by 1,2-dimethylhydrazine (DMH) were found to be 1/2 the concentration found in normal large bowel tissue. Intracellular concentrations of guanosine 3'-5'-cyclic monophosphate (cGMP) in ...

journal_title：Cancer letters

authors： Stevens RH,Loven DP,Osborne JW,Prall JP,Lawson AJ

更新日期：1978-01-01 00:00:00