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Enhancement of non-homologous end joining DNA repair capacity confers cancer cells resistance to the novel selenophene compound, D-501036.

Abstract：

:D-501036 is a promising anti-cancer compound that exhibits potent anti-proliferative activity against various types of human cancers through the induction of double strand DNA breaks. To determine drug resistance mechanism related to this class of DNA-damaging agents, a KB-derived D-501036-resistant cell line (S4) was established. Results showed that S4 cells exhibit enhanced DNA rejoining ability as compare to KB cells, through up-regulation of the non-homologous end joining activity. In conclusion, enhancement of NHEJ activity plays important role in the development of D-501036-resistance and targeting NHEJ-related molecules maybe able to overcome drug resistance to DNA damaging agents.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Yang YN,Chou KM,Pan WY,Chen YW,Tsou TC,Yeh SC,Cheung CH,Chen LT,Chang JY

doi

10.1016/j.canlet.2011.05.023

subject

Has Abstract

pub_date

2011-10-01 00:00:00

pages

110-8

issue

1

eissn

0304-3835

issn

1872-7980

pii

S0304-3835(11)00300-4

journal_volume

309

pub_type

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