Formation of mutagens in cooked foods. V. The mutagen reducing effect of soy protein concentrates and antioxidants during frying of beef.

Abstract:

:Cooking beef patties results in the formation of mutagens detectable by Salmonella typhimurium TA98 with metabolic activation. Decreased mutagenic activity results when frying beef with added soy protein concentrates (SPC). The reduction in mutagenicity takes place during the cooking process. Whereas fried beef hamburgers show high mutagenic activity, by comparison, similarly fried soy-hamburgers have much less mutagenic activity. Volumetric effects are responsible partly for the reduction on mutagenicity by SPC. Naturally occurring antioxidants in SPC, such as chlorogenic acid, also play a role. Also, a commonly used antioxidant, butylated hydroxyanisole (BHA), has been found effective in reducing the mutagenicity of fried beef. Thus, the addition of SPC or BHA in beef patties may provide a practical way of reducing mutagen formation during frying of beef.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Wang YY,Vuolo LL,Spingarn NE,Weisburger JH

doi

10.1016/0304-3835(82)90059-3

subject

Has Abstract

pub_date

1982-07-01 00:00:00

pages

179-89

issue

2

eissn

0304-3835

issn

1872-7980

pii

0304-3835(82)90059-3

journal_volume

16

pub_type

杂志文章
  • Anti-tumor and radiosensitization activities of the iron chelator HDp44mT are mediated by effects on intracellular redox status.

    abstract::A novel iron chelator, HDp44mT, has been reported to have potent anti-proliferative effects on cancer cells; however, the underlying mechanism of action is not well understood. In this study, we characterized the cytotoxic effect of HDp44mT in a chemo- and radio-resistant cell line (PC-3) of prostatic cancer origin. T...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2010.07.010

    authors: Tian J,Peehl DM,Zheng W,Knox SJ

    更新日期:2010-12-08 00:00:00

  • Neo-angiogenesis and the premalignant micro-circulatory augmentation of early colon carcinogenesis.

    abstract::Spectroscopic techniques have demonstrated that in the microscopically normal mucosa, there is an increase in mucosal micro-circulation in patients harboring neoplasia elsewhere in the colon (i.e. marker of field carcinogenesis). However, the physiological and molecular basis of this early increase in blood supply (EI...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2011.03.008

    authors: Tiwari AK,Crawford SE,Radosevich A,Wali RK,Stypula Y,Kunte DP,Mutyal N,Ruderman S,Gomes A,Cornwell ML,De La Cruz M,Brasky J,Gibson TP,Backman V,Roy HK

    更新日期:2011-07-28 00:00:00

  • Frequent loss of heterozygosity on multiple chromosomes in Chinese esophageal squamous cell carcinomas.

    abstract::Analysis of the loss of heterozygosity (LOH) detected by polymerase chain reaction techniques using 18 polymorphic markers localized to chromosomes 3p, 5, 17, and 18q in 40 Hong Kong Chinese esophageal squamous cell carcinoma (ESC) patients showed that multiple alterations on several chromosomes are involved in ESC de...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3835(01)00577-8

    authors: Ko JM,Wong CP,Tang CM,Lau KW,Lung ML

    更新日期:2001-09-20 00:00:00

  • A novel antitumor activity of deguelin targeting the insulin-like growth factor (IGF) receptor pathway via up-regulation of IGF-binding protein-3 expression in breast cancer.

    abstract::In this study, we investigated the antitumor effects of deguelin in several human breast cancer cells in vitro and in vivo. Deguelin inhibited cell viability and the anchorage-dependent and anchorage-independent colony formation of triple-negative (MDA-MB-231 and MDA-MB-468) and triple-positive (MCF-7) breast cancer c...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2013.01.022

    authors: Suh YA,Kim JH,Sung MA,Boo HJ,Yun HJ,Lee SH,Lee HJ,Min HY,Suh YG,Kim KW,Lee HY

    更新日期:2013-05-10 00:00:00

  • Effect of magnesium hydroxide on methylazoxymethanol acetate-induced epithelial proliferation in the large bowels of rats.

    abstract::The effect of magnesium hydroxide on the epithelial proliferation of the large bowel was examined using rats given methylazoxymethanol (MAM) acetate. Dietary administration of magnesium hydroxide at 250, 500, 1000 or 2000 ppm. for 1, 3 or 5 weeks did not influence the cell cycle of the cryptal cells of the large bowel...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/0304-3835(92)90196-3

    authors: Mori H,Morishita Y,Mori Y,Yoshimi N,Sugie S,Tanaka T

    更新日期:1992-02-14 00:00:00

  • Suppression of the promoter effect of polyunsaturated fatty acids by the absence of dietary vitamin E in experimental mammary carcinoma.

    abstract::Because lipoperoxides seem able to modulate tumor growth, we have examined the concomitant effects of dietary antioxidant (vitamin E) and of a high amount of polyunsaturated fatty acids (PUFA) in a model of chemically-induced mammary carcinogenesis. Two groups of rats received a high fat diet with or without added vit...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3835(97)04671-5

    authors: Lhuillery C,Cognault S,Germain E,Jourdan ML,Bougnoux P

    更新日期:1997-03-19 00:00:00

  • The predictive power of CD3+ T cell infiltration of oral squamous cell tumors is limited to non-diabetic patients.

    abstract::Diabetes mellitus type II (DM) and immune cell infiltration determine patient outcome in many tumor entities. Here we studied a possible link between the metabolic and immune cell status of OSCC patients. Glucose transporter (GLUT) 1 mRNA expression was elevated in all tumor samples, whereas other glycolytic markers s...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2020.11.029

    authors: Spanier G,Ugele I,Nieberle F,Symeou L,Schmidhofer S,Brand A,Meier J,Spoerl S,Krupar R,Rümmele P,Siska P,Renner K,Peter K,Gerken M,Beckhove P,Reichert TE,Kreutz M,Singer K

    更新日期:2021-02-28 00:00:00

  • Progesterone receptor membrane component 1 deficiency attenuates growth while promoting chemosensitivity of human endometrial xenograft tumors.

    abstract::Endometrial cancer is the leading gynecologic cancer in women in the United States with 52,630 women predicted to be diagnosed with the disease in 2014. The objective of this study was to determine if progesterone (P4) receptor membrane component 1 (PGRMC1) influenced endometrial cancer cell viability in response to c...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2014.09.036

    authors: Friel AM,Zhang L,Pru CA,Clark NC,McCallum ML,Blok LJ,Shioda T,Peluso JJ,Rueda BR,Pru JK

    更新日期:2015-01-28 00:00:00

  • Factors influencing the activity of dimethylnitrosamine demethylase in hamster, rat and chicken liver microsomes.

    abstract::In vitro metabolism of dimethylnitrosamine (DMN) by liver microsomal fractions of hamster, rat and chicken revealed that the three species under certain assay conditions, were capable of metabolizing DMN at different rates (hamster greater than rat greater than chicken). The magnitude of the demethylase activity was f...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/0304-3835(85)90169-7

    authors: Prasanna HR,Lotlikar PD,Brandt C,Magee PN

    更新日期:1985-02-01 00:00:00

  • Long non-coding RNAs: Emerging regulators for chemo/immunotherapy resistance in cancer stem cells.

    abstract::Cancer stem cells (CSCs) are a small subpopulation of tumor cells critical for tumor development. Their unique abilities, such as self-renewal, have resulted in tumor resistance to various cancer treatments, including traditional chemotherapy and latest immunotherapy. CSCs-targeting therapy is a promising treatment to...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2020.11.010

    authors: Shen C,Yang C,Xia B,You M

    更新日期:2021-03-01 00:00:00

  • Drug accumulation and DNA platination in cells exposed to aquated cisplatin species.

    abstract::Since CP always exists in aqueous solution as a mixture of native drug and various aqua and hydroxo species, it is conceivable that one or more of these aquated species is the main form of the drug that enters the cell. To test this hypothesis, we examined the accumulation by 2008 human ovarian carcinoma cells of CP a...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/0304-3835(94)90205-4

    authors: Jennerwein M,Andrews PA

    更新日期:1994-06-30 00:00:00

  • Suppression of Ehrlich ascites tumor growth in mice by starvation and streptozotocin-induced diabetes.

    abstract::Starvation-induced hypoglycaemia and streptozotocin-induced diabetes suppressed the growth of Ehrlich ascites tumor in mice. The suppression of tumor growth by diabetes was alleviated by administration of insulin. The number of glucose carriers on tumour cells was found to be reduced in diabetes and partial resumption...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/0304-3835(85)90035-7

    authors: Fung KP,Chan TW,Choy YM

    更新日期:1985-09-30 00:00:00

  • Microsatellite instability in Japanese hereditary non-polyposis colorectal cancer does not induce mutation of a simple repeat sequence of the bax gene.

    abstract::The identification of frameshift mutations in the coding region of the bax gene in Western cases of hereditary non-polyposis colorectal cancer provided evidence that the disease could be caused by the disruption of a tumor suppressor gene associated with microsatellite instability. In order to determine whether this o...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3835(97)00477-1

    authors: Sakakibara T,Nakamura T,Yamamoto M,Matsuo M

    更新日期:1998-02-27 00:00:00

  • Proteomics-based identification of autoantibody against heat shock protein 70 as a diagnostic marker in esophageal squamous cell carcinoma.

    abstract::Detection of novel tumor-related antigens and autoantibodies in cancer patients is expected to facilitate the diagnosis of early-stage malignant tumor and establish effective new immunotherapies. The purpose of this study was to identify novel tumor antigens in an esophageal squamous cell carcinoma (ESCC) cell line (T...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2008.01.013

    authors: Fujita Y,Nakanishi T,Miyamoto Y,Hiramatsu M,Mabuchi H,Miyamoto A,Shimizu A,Takubo T,Tanigawa N

    更新日期:2008-05-18 00:00:00

  • Heterogeneity of liver cancer and personalized therapy.

    abstract::Liver cancer is an extraordinarily heterogeneous malignant disease among the tumors that have so far been identified. Hepatocellular carcinoma (HCC) arises most frequently in the setting of chronic liver inflammation and fibrosis, and takes a variety of course in individual patients to process to tumor. The risk facto...

    journal_title:Cancer letters

    pub_type: 杂志文章,评审

    doi:10.1016/j.canlet.2015.07.018

    authors: Li L,Wang H

    更新日期:2016-09-01 00:00:00

  • Staurosporine-induced G(1) arrest in cancer cells depends on an intact pRB but is independent of p16 status.

    abstract::Staurosporine and its derivative 7-hydroxystaurosporine are protein kinase inhibitors that are being considered for treatments of cancers. Several recent studies have shown that cells with defective pRB protein are resistant to the G(1) cell cycle-inhibiting effects of staurosporine compounds. In this study, we examin...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3835(02)00101-5

    authors: Zhou W,Lin Y,Wersto R,Chrest J,Gabrielson E

    更新日期:2002-09-08 00:00:00

  • Human p53(264-272) HLA-A2 binding peptide is an immunodominant epitope in DNA-immunized HLA-A2 transgenic mice.

    abstract::C57BL/10 mice transgenic for HLA-A2 were immunized with either a full-length DNA-construct of the tumor suppressor p53 or with a minigene encoding the p53-derived immunodominant peptide p53(264)LLGRNSFEV272 (L9V). Vaccination with the full-length p53 construct induced potent cytotoxic activity of splenocytes against L...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3835(98)00353-x

    authors: Petersen TR,Bregenholta S,Pedersen LO,Nissen MH,Claesson MH

    更新日期:1999-04-01 00:00:00

  • Deoxycytidine in human plasma: potential for protecting leukemic cells during chemotherapy.

    abstract::Degradation of DNA produces deoxycytidine. Metabolism of deoxycytidine to dCTP inhibits phosphorylation of cytosine arabinoside (araC), fludarabine (FaraA) and 2-chlorodeoxyadenosine (CdA) by deoxycytidine kinase. This study measured plasma deoxycytidine in healthy adults and two leukemia patients and then determined ...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3835(97)00185-7

    authors: Cohen JD,Strock DJ,Teik JE,Katz TB,Marcel PD

    更新日期:1997-06-24 00:00:00

  • The inhibition of tumor growth by triplex-forming oligonucleotides.

    abstract::We have previously shown that oligonucleotides designed to bind in triplex fashion to a specific p53 binding site homology inhibit the proliferation of colon cancer cells in vitro. The present study was designed to extend these observations in an in vivo model. HCT 116 human colon carcinoma cells were injected subcuta...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2004.02.002

    authors: Re RN,Cook JL,Giardina JF

    更新日期:2004-06-08 00:00:00

  • The soluble EP2 receptor FuEP2/Ex2 suppresses endometrial cancer cell growth in an orthotopic xenograft model in nude mice.

    abstract::Endometrial cancer is one of the most common gynecologic malignancies and many factors influence in its growth and development. As in many other types of cancer, prostaglandin E(2) (PGE(2)) is thought to be an accelerator of cell proliferation and endometrial cancer progression. In this study, we examined the effect o...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2011.02.033

    authors: Takahashi T,Ogawa H,Izumi K,Uehara H

    更新日期:2011-07-01 00:00:00

  • A novel class of antitumour agents. II. In vitro testing.

    abstract::Suspensions of Walker and HeLa cells, rat fibroblasts and human stimulated lymphocytes were incubated over various periods with the synthetic amino steroid, 2 beta,16 beta-dipiperidino-5 alpha-androstane-3 alpha,17 beta-diol dipivalate (DAP). The acute cell destroying effect was found to be exponentially time and dose...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3835(77)80032-3

    authors: Emminger A,Kahmann E,Savage DS

    更新日期:1977-03-01 00:00:00

  • Comparative reduction of 1-nitro-3-nitrosopyrene and 1-nitro-6-nitrosopyrene: implications for the tumorigenicity of dinitropyrenes.

    abstract::Dinitropyrenes are mutagenic environmental pollutants. Of these compounds, 1,6-dinitropyrene is a potent tumorigen while 1,3-dinitropyrene appears to be weakly or non-tumorigenic. Two-electron reduction of dinitropyrenes yields nitro-nitrosopyrenes, which have been shown previously to be the major aerobic metabolites ...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/0304-3835(92)90215-h

    authors: Djuric Z

    更新日期:1992-07-31 00:00:00

  • Activation of reactive oxygen species/AMP activated protein kinase signaling mediates fisetin-induced apoptosis in multiple myeloma U266 cells.

    abstract::We investigated the molecular mechanisms responsible for fisetin-induced apoptosis in U266 cells. Fisetin elicited the cytotoxicity in U266 cells, manifested as an increased fraction of the cells with sub-G1 content or stained positively with TUNEL labeling. Fisetin enhanced caspase-3 activation, downregulation of Bcl...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2012.01.008

    authors: Jang KY,Jeong SJ,Kim SH,Jung JH,Kim JH,Koh W,Chen CY,Kim SH

    更新日期:2012-06-28 00:00:00

  • The inhibitor of differentiation-1 (Id1) enables lung cancer liver colonization through activation of an EMT program in tumor cells and establishment of the pre-metastatic niche.

    abstract::Id1 promotes carcinogenesis and metastasis, and predicts prognosis of non-small cell lung cancer (NSCLC)-adenocarcionoma patients. We hypothesized that Id1 may play a critical role in lung cancer colonization of the liver by affecting both tumor cells and the microenvironment. Depleted levels of Id1 in LLC (Lewis lung...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2017.05.012

    authors: Castañón E,Soltermann A,López I,Román M,Ecay M,Collantes M,Redrado M,Baraibar I,López-Picazo JM,Rolfo C,Vidal-Vanaclocha F,Raez L,Weder W,Calvo A,Gil-Bazo I

    更新日期:2017-08-28 00:00:00

  • Synergistic anti-tumor effect of combination radio- and immunotherapy by electro-gene therapy plus intra-tumor injection of dendritic cells.

    abstract::Interleukin-2 (IL-2) and granulocyte-macrophage colony stimulating factor (GM-CSF) facilitate the maturation and functioning of injected DC. We developed a method of in situ electroporation using IL-2 and GM-CSF genes (EGT/cytokines), followed by intra-tumoral (i.t.) immature DC to determine the immune response at the...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2008.02.063

    authors: Wang YS,Tsang YW,Chi CH,Chang CC,Chu RM,Chi KH

    更新日期:2008-08-08 00:00:00

  • Decreased plasma levels of cholecystokinin in healthy males after chronic ingestion of a heat-treated soya product.

    abstract::Administration of raw soya containing a trypsin inhibitor stimulated excessive release of cholecystokinin (CCK) which led to pancreatic hypertrophy, hyperplasia and cancer in the rats (Booth et al. (1964) Proc. Soc. Exp. Biol. Med., 116, 1067). More postprandial CCK release in healthy humans was observed after ingesti...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/0304-3835(95)03697-u

    authors: Lu LJ,Anderson KE,Gomez G,Nealon WH

    更新日期:1995-04-14 00:00:00

  • Transplacental carcinogenic effect of n-nitrosoethylurea in dogs.

    abstract::During the late period of pregnancy (on the 50th and 53rd days post coitum) 2 dogs were injected intraperitoneally with 100 mg/kg (a single administration) of nitrosoethylurea. Nine puppies were born. During the 9 year period of observation no tumours were detected in mother-dogs. Three of 9 offspring developed the fo...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/0304-3835(81)90052-5

    authors: Napalkov NP,Alexandrov VA,Anisimov VN

    更新日期:1981-03-01 00:00:00

  • Secretory Stanniocalcin 1 promotes metastasis of hepatocellular carcinoma through activation of JNK signaling pathway.

    abstract::The hypoxic microenvironment is well-characterized in hepatocellular carcinoma (HCC). Delineation of hypoxia-responsive events is an integral part to understand the pathogenesis of HCC. We studied the functional role and clinical relevance of Stanniocalcin 1 (STC1), a hypoxia-induced molecular target, in HCC. In our c...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2017.06.034

    authors: Chan KK,Leung CO,Wong CC,Ho DW,Chok KS,Lai CL,Ng IO,Lo RC

    更新日期:2017-09-10 00:00:00

  • Engineering death receptor ligands for cancer therapy.

    abstract::CD95, TNFR1, TRAILR1 and TRAILR2 belong to a subgroup of TNF receptors which is characterized by a conserved cell death-inducing protein domain that connects these receptors to the apoptotic machinery of the cell. Activation of death receptors in malignant cells attracts increasing attention as a principle to fight ca...

    journal_title:Cancer letters

    pub_type: 杂志文章,评审

    doi:10.1016/j.canlet.2010.12.019

    authors: Wajant H,Gerspach J,Pfizenmaier K

    更新日期:2013-05-28 00:00:00

  • Strain comparison of systemic N-nitrosohexamethyleneimine carcinogenesis in BALB/c, SENCAR and CD-1 mice.

    abstract::SENCAR mice have been selectively bred for hypersusceptibility to 2-stage chemical skin carcinogenesis. In this study the relative susceptibilities of SENCAR, BALB/c and CD-1 mice to systemic carcinogenesis by N-nitrosohexamethyleneimine (NHEX) were examined. NHEX was administered twice weekly (1 mg/mouse) in corn oil...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/0304-3835(88)90110-3

    authors: Strickland PT,Lijinsky W,Thomas B,Kovatch RM

    更新日期:1988-08-15 00:00:00