Abstract:
:Analysis of the loss of heterozygosity (LOH) detected by polymerase chain reaction techniques using 18 polymorphic markers localized to chromosomes 3p, 5, 17, and 18q in 40 Hong Kong Chinese esophageal squamous cell carcinoma (ESC) patients showed that multiple alterations on several chromosomes are involved in ESC development. The LOH rates detected for markers on chromosome 3 ranged from 44.0 to 85.7%, for chromosome 5 from 40.9 to 61.9%, for chromosome 17 from 40.0 to 100%, and for chromosome 18 from 38.9 to 58.3%. No significant association was observed between LOH and the clinical and histopathological parameters.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Ko JM,Wong CP,Tang CM,Lau KW,Lung MLdoi
10.1016/s0304-3835(01)00577-8keywords:
subject
Has Abstractpub_date
2001-09-20 00:00:00pages
131-8issue
2eissn
0304-3835issn
1872-7980pii
S0304383501005778journal_volume
170pub_type
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