Abstract:
:Starvation-induced hypoglycaemia and streptozotocin-induced diabetes suppressed the growth of Ehrlich ascites tumor in mice. The suppression of tumor growth by diabetes was alleviated by administration of insulin. The number of glucose carriers on tumour cells was found to be reduced in diabetes and partial resumption of glucose carriers was observed in tumour cells of diabetes after insulin administration. Insulin had no direct effect on tumour growth in vivo and did not affect the number of glucose carriers on tumour cells in vitro. The physiological significance of these observations is discussed.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Fung KP,Chan TW,Choy YMdoi
10.1016/0304-3835(85)90035-7subject
Has Abstractpub_date
1985-09-30 00:00:00pages
273-80issue
3eissn
0304-3835issn
1872-7980pii
0304-3835(85)90035-7journal_volume
28pub_type
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