Abstract:
:NF-kappaB is activated in many types of cancer. Phosphorylation of p65 at serine 276 is required for the expression of a subset of NF-kappaB regulated genes, including vascular cell adhesion molecule-1 (VCAM-1) and interleukin-8 (IL-8). Thus, inhibition of serine 276 phosphorylation may prevent metastasis and angiogenesis in certain tumor types. Using in silico molecular docking, small molecules that are predicted to bind to a structural pocket near serine 276 were identified. One compound, NSC-127102, hinders serine 276 phosphorylation and the expression of IL-8 and VCAM-1. Small molecules such as NSC-127102 may be optimized for the future treatment of cancer.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Law M,Corsino P,Parker NT,Law BKdoi
10.1016/j.canlet.2009.10.015subject
Has Abstractpub_date
2010-05-28 00:00:00pages
217-24issue
2eissn
0304-3835issn
1872-7980pii
S0304-3835(09)00637-5journal_volume
291pub_type
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