Abstract：
:Vascular normalisation, the process that reverses the structural and functional abnormalities seen in tumour-associated vessels, is also accompanied by changes in leucocyte trafficking. Our previous studies have shown the normalisation effects of the agent CD5-2 which acts to stabilise VE-Cadherin leading to increased penetration of CD8+ T cells but decreased infiltration of neutrophils (CD11b+Gr1hi) into tumour parenchyma. In the present study, we demonstrate that VE-Cadherin stabilisation through CD5-2 treatment of purified endothelial cells (ECs) results in a similar leucocyte-selective regulation of transmigration, suggesting the existence of an endothelial specific intrinsic mechanism. Further, we show by RNA sequencing (RNA-seq)-based transcriptomic analysis, that treatment of ECs with CD5-2 regulates chemokines known to be involved in leucocyte transmigration, including upregulation of CCL2 and CXCL10 that facilitate CD8+ T cell transmigration. Both in vitro and in vivo mechanistic studies revealed that the increased CCL2 expression was dependent on expression of VE-Cadherin and downstream activation of the AKT/GSK3β/β-catenin/TCF4 signalling pathway. CD5-2 treatment also contributed to the reorganisation of the cytoskeleton, inducing reorganisation of stress fibres to circumferential actin, which previously has been described as associated with the stabilisation of the endothelial barrier, and amplification of the transcellular migration of CD8+ T cells. Thus, we propose that promotion of endothelial junctional integrity during vascular normalisation not only inhibits vascular leak but also resets the endothelial dependent regulation of immune cell infiltration.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Zhao Y,Li J,Ting KK,Chen J,Coleman P,Liu K,Wan L,Moller T,Vadas MA,Gamble JRdoi
10.1016/j.canlet.2020.09.026subject
Has Abstractpub_date
2021-01-01 00:00:00pages
1-15eissn
0304-3835issn
1872-7980pii
S0304-3835(20)30496-1journal_volume
496pub_type
杂志文章相关文献
CANCER LETTERS文献大全abstract：:ING family genes (Inhibitor of Growth) are tumor suppressor genes that play a vital role in cell homeostasis. It has been shown that their expression is lost or diminished in many cancers and other diseases. The main mechanisms by which they are regulated in oncogenesis have not yet been fully elucidated. The involvem...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2019.01.006
更新日期：2019-04-10 00:00:00
abstract：:Mining and mineral processing are important industries in the United States. A large number of workers are potentially exposed to silica during mining and to glass fibers during manufacturing. There is a concern regarding lung cancer risk among workers exposed to silica and glass fibers. Our previous studies showed th...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(96)04546-6
更新日期：1997-01-15 00:00:00
abstract：:The tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a lung carcinogen in the rat and believed to be a causative agent for lung cancer in smokers. To exert its carcinogenic potential NNK is metabolically activated by cytochrome P450-catalyzed alpha-hydroxylation. Nicotine and NNK s...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2003.07.004
更新日期：2003-12-08 00:00:00
abstract：:We investigated the relative effectiveness of four differentiation-inducing chemicals to induce a more normal or benign phenotype in the human colon cancer cell lines Moser and HT29. The differentiation-inducing capability of all-trans retinoic acid (ATRA), difluoromethylornithine (DFMO), sodium butyrate (NaB) and sod...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(98)00242-0
更新日期：1998-12-11 00:00:00
abstract：:6-(1-Hydroxyimino-4-methylpentyl)5,8-dimethyoxy 1,4-naphthoquinone S-52 (DMNQ S-52) was reported to have cytotoxic activity against L1210 leukemia cells. In the present study, we investigated the apoptotic mechanism of DMNQ S-52 in vitro and in vivo in murine solid cancer cells. DMNQ S-52 exerted cytotoxicity against ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2005.02.042
更新日期：2006-02-20 00:00:00
abstract：BACKGROUND AND AIMS:Understanding the molecular pathogenesis of hepatocellular carcinoma (HCC) is essential to identify therapeutic targets. A hepatitis B virus (HBV) related double transgenic murine model was developed. METHODS:Liver specific expression of HBV X protein (HBx) and insulin receptor substrate 1 (IRS1) w...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2015.09.016
更新日期：2016-01-01 00:00:00
abstract：:Berberine, an isoquinoline alkaloid, has a wide range of pharmacological effects, including anti-inflammation, yet the exact mechanism is unknown. Because cyclooxygenase-2 (COX-2) plays a key role in prostaglandins (PGs) synthesis, which is elevated in inflammation, we examined whether the anti-inflammatory mechanism ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2003.09.002
更新日期：2004-01-20 00:00:00
abstract：:As a continuation of studies using natural and synthetic products as cancer chemopreventive agents, we examined the reduction-oxidation potentials of hydroxylated emodin derivatives prepared from emodin in phosphate buffer at pH 7.2 using cyclic voltammetry. A significant correlation was found between the reduction po...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2005.10.043
更新日期：2006-09-28 00:00:00
abstract：:Celecoxib has a potential role for oral cancer chemoprevention but its systemic side effects are a concern. Topical chemoprevention is a promising way to reduce the toxicity. This study was designed to determine whether topical application of polymer delivered celecoxib would have an inhibitory effect on human oral ca...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(03)00272-6
更新日期：2003-07-30 00:00:00
abstract：:Gastric cancer (GC) is a major threat to human health, and its prognosis is poor due to the lack of appropriate biomarkers. LncRNAs are a group of non-protein-coding RNAs that regulate gene expression at the transcriptional or posttranscriptional level. LncRNAs play essential roles in GC initiation and development in ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2015.11.011
更新日期：2016-02-01 00:00:00
abstract：:Gene methylation is an important molecular event in prostate carcinogenesis that may have diagnostic and prognostic significance. We evaluated the methylation status of eight genes implicated in prostate carcinogenesis. DNA was extracted from archived paraffin-embedded tumor blocks from 90 prostate cancer patients. Ge...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2003.11.027
更新日期：2004-03-18 00:00:00
abstract：:Application of functional imaging to radiotherapy (RT) is a rapidly expanding field with the development of new modalities and techniques. Functional imaging of PET in conjunction with RT provides new avenues towards the clinical application of dose painting - a new RT strategy delivering optimized dose redistribution...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2014.07.042
更新日期：2014-12-28 00:00:00
abstract：:Costunolide, the predominant sesquiterpene lactone in Saussureae radix, has been reported to exhibit potent chemopreventive effects on carcinogenesis. Effects of costunolide on cellular activation induced by a tumor-promoting phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) were investigated using a reporter g...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(00)00704-7
更新日期：2001-03-10 00:00:00
abstract：:It was found that free radical intermediates, pyrazine cation radial and carbon-centered radicals, generated in the Maillard reaction of sugars/amino acids, were involved in the production of mutagenic and carcinogenic imidazoquinoquizaline heterocyclic amines. Prevention of the generation of these radical intermediat...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(99)00140-8
更新日期：1999-09-01 00:00:00
abstract：:Two hair dye components, carcinogenic 4-nitro-2-aminophenol and 5-nitro-2-aminophenol, induced Cu(II)-dependent DNA cleavage frequently at thymine and guanine residues in DNA fragments obtained from the c-Ha-ras-1 protooncogene. When the p53 tumor suppressor gene was used, 4-nitro-2-aminophenol caused Cu(II)-dependent...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(97)00533-8
更新日期：1998-04-10 00:00:00
abstract：:Monitoring angiogenesis is potentially an effective strategy for the early detection of cancer. In this study, early detection was achieved by evaluating blood vessel density in the liver using a three-dimensional contrast-enhanced high-frequency ultrasound (CE-HFUS) system and Sonazoid microbubbles. Three-dimensional...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2013.06.006
更新日期：2013-10-10 00:00:00
abstract：:Metastatic colonization involves paracrine/juxtacrine interactions with the microenvironment inducing an adaptive response through transcriptional regulation. However, the identities of transcription factors (TFs) induced by the metastatic microenvironment in ovarian cancer (OC) and their mechanism of action is poorly...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2017.11.012
更新日期：2018-02-01 00:00:00
abstract：:Human promyelocytic leukemia cells (HL-60) were found to be induced by dimethylsulfoxide and several other compounds to phagocytize, reduce NBT dye, and change into forms that were morphologically similar to granulocytes and macrophages. Arginase also induced these differentiation-associated properties of the cells. T...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(80)90044-0
更新日期：1980-10-01 00:00:00
abstract：:In many parts of the world, green tea and black tea are produced from the plant Camellia sinensis. Tea is one of the most widely consumed beverages, second only to water. It is one of the safest beverages since it is made with boiling, sterile water and has been popular for over 4000 years. Dogma has it that people kn...
journal_title：Cancer letters
pub_type： 历史文章,杂志文章
doi：10.1016/s0304-3835(97)04691-0
更新日期：1997-03-19 00:00:00
abstract：:The mucosal glutathione content of the gastrointestinal wall amounted to 50-60% of its concentration in the liver. GSH S-aryltransferase activity (CDNB) was very low in the glandular stomach, colon and rectum amounting to only 5% of liver enzyme activity. There was a marked postpyloric increase in GSH S-aryltransferas...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(88)90263-7
更新日期：1988-05-01 00:00:00
abstract：:The identification of the breast cancer susceptibility genes BRCA1 and BRCA2 a few years ago has been greeted with great excitement and has raised hopes that they might illuminate the common mechanisms of this disease. Today we have to recognize that these expectations remain unfulfilled. Mutations in BRCA1 and BRCA2 ...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/s0304-3835(01)00752-2
更新日期：2002-01-10 00:00:00
abstract：:The environmental mutagens, 1-nitropyrene, 1,3-dinitropyrene, 1,6-dinitropyrene and 1,8-dinitropyrene were evaluated for their ability to initiate skin tumors in male and female SENCAR mice. 1-Nitropyrene (greater than 99.5% purity) did not induce papilloma formation over a dose range of 0-3.0 mg/mouse after 30 weeks ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(84)90055-7
更新日期：1984-05-01 00:00:00
abstract：:Medroxyprogesterone acetate (MPA) is currently used therapeutically in the treatment of mammary and endometrial carcinomas. In order to develop a more potent and useful drug, we synthesized the novel compound, 9alpha-fluoromedoroxyprogesterone acetate (FMPA), by fluorinating MPA, and we also previously reported that F...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(00)00375-x
更新日期：2000-06-01 00:00:00
abstract：:We evaluated the influence of age and sex on rectal cell proliferation of 69 hospital controls and 66 patients with colorectal adenomas, by means of incubation of rectal biopsies with tritiated thymidine and autoradiography. In particular, we evaluated the labeling frequency in the upper 40% of rectal crypts (0 h), ac...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(90)90203-a
更新日期：1990-09-01 00:00:00
abstract：:Effects of eight heterocyclic amines (HCAs) on pancreatic duct carcinogenesis were investigated in a rapid production model in hamsters. N-Nitrosobis(2-oxopropyl)amine (BOP) was given to effect initiation, followed by augmentation pressure consisting of four daily i.p. injections of 500 mg/kg DL-ethionine, a choline-d...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(99)00131-7
更新日期：1999-09-01 00:00:00
abstract：:The mixed lineage kinase domain-like protein (MLKL) has emerged as a critical mediator of necroptosis, which results in the release of cellular damage-associated molecular patterns (DAMPs). However, its physiological role in regulating inflammation is not fully understood. We herein showed that Mlkl-/- mice were highl...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2019.05.034
更新日期：2019-09-10 00:00:00
abstract：:The past two decades have seen a dramatic change in cancer treatment paradigms. Anticancer agents are no longer being developed based on empiricism and serendipity, but are now being aimed to inhibit a validated target that is relatively specific for tumours rather than normal cells. The vast majority of cancers arise...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2006.03.012
更新日期：2007-01-08 00:00:00
abstract：:The carcinogenic effect of dimethylnitrosamine (DMN) s.c. injected at two different dose levels was studied in laboratory bred European hamsters (EH) and data compared to findings for captured EH. Malignant haemangioendotheliomas of the liver and kidney, hepatocellular carcinomas and cholangiocarcinomas were induced. ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(78)92972-5
更新日期：1978-01-01 00:00:00
abstract：:The present study aims to evaluate the antitumor activity of silybin nanosuspension on human prostatic carcinoma PC-3 cell line in vitro. Silybin nanosuspension was prepared by the high pressure homogenization (HPH) method. MTT assay, observation of morphological changes and apoptotic body showed that silybin nanosusp...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2011.03.028
更新日期：2011-08-28 00:00:00
abstract：:Hepatocytes were isolated from B6C3F1 male mouse neoplastic livers (containing hepatocellular adenomas and carcinomas) or two-thirds partially hepatectomized livers and tested in primary culture for their cytotoxic response to hepatotoxins. Partially hepatectomized mouse hepatocytes were less sensitive to lindane, met...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(85)90053-9
更新日期：1985-04-01 00:00:00
