Differentiation-inducing effect of retinoic acid, difluoromethylornithine, sodium butyrate and sodium suramin in human colon cancer cells.

abstract：:Certain polyunsaturated fatty acids can selectively kill tumor cell lines while causing little to no harm to normal cell lines. However, the mechanism of this cytotoxicity is only partially understood. Antioxidants such as vitamin E have been shown to be capable of completely blocking the cytotoxic response when admin...

journal_title：Cancer letters

authors： Ells GW,Chisholm KA,Simmons VA,Horrobin DF

更新日期：1996-01-02 00:00:00

abstract：:We constructed an SV40-derived expression vector containing a mutated albumin minigene of Nagase analbuminemic rats (NAR), and introduced it into cultured cells. Transient expression of the minigene mRNA was determined by RT-PCR. Three kinds of aberrant mRNAs were expressed by the non-hepatic cells COS-1, and the undi...

journal_title：Cancer letters

authors： Sugiyama K,Hitomi Y,Adachi H,Esumi H

更新日期：1994-08-15 00:00:00

abstract：:Primary liver cancer is the fifth most common cancer worldwide and hepatocellular carcinoma (HCC) accounts for over 85% of all primary liver cancers. The clinical management of advanced and metastatic HCC is challenging on many counts. Besides largely occurs within a background of underlying chronic liver disease and ...

journal_title：Cancer letters

authors： Hui KM

更新日期：2009-12-01 00:00:00

abstract：:The effects of di(2-ethylhexyl)phthalate (DEHP), a widely used plasticizer and environmental contaminant, on the emergence of gamma-glutamyltrans-peptidase positive (GGT+) preneoplastic foci in the liver was investigated. Sprague--Dawley male rats initiated with diethylnitrosamine (DEN) following partial hepatectomy w...

journal_title：Cancer letters

authors： Deangelo AB,Garrett CT

更新日期：1983-09-01 00:00:00

abstract：:Patients (459) with chronic gastritis, ulcers, polyposis and different types of gastric cancers were examined by endoscopic fluorescent technique using a special drug based on the sodium salt of fluorescein (F1). Eighty-five percent of gastric cancers showed positive fluorescence. The F1 distribution in the stomach of...

journal_title：Cancer letters

authors： Braginskaja OV,Lazarev VV,Polsachev VI,Rubin LB,Stoskii VE

更新日期：1993-04-30 00:00:00

abstract：:Endometrial cancer is the leading gynecologic cancer in women in the United States with 52,630 women predicted to be diagnosed with the disease in 2014. The objective of this study was to determine if progesterone (P4) receptor membrane component 1 (PGRMC1) influenced endometrial cancer cell viability in response to c...

journal_title：Cancer letters

authors： Friel AM,Zhang L,Pru CA,Clark NC,McCallum ML,Blok LJ,Shioda T,Peluso JJ,Rueda BR,Pru JK

更新日期：2015-01-28 00:00:00

abstract：:We subcutaneously inoculated parental and glioma cells genetically engineered to express interleukin-2 (SR/IL-2) into syngeneic mice. The tumor growth of the transfectants was slower than that of the parental cells. We then stereotactically inoculated transfectants into the brains of mice. The survival of the mice inj...

journal_title：Cancer letters

authors： Kikuchi T,Joki T,Akasaki Y,Abe T,Ohno T

更新日期：1999-01-08 00:00:00

abstract：:Macrophages that infiltrate tumor tissues, or tumor-associated macrophages (TAMs), affect the malignant behaviors of tumor cells. In this study, we attempted to induce monocytes to differentiate into TAM-like cells producing matrix metalloproteinases (MMPs) by co-culture with tumor cells. When human monocytes were co-...

journal_title：Cancer letters

authors： Kamoshida G,Matsuda A,Sekine W,Mizuno H,Oku T,Itoh S,Irimura T,Tsuji T

更新日期：2012-02-28 00:00:00

abstract：:Given its contribution to malignant phenotypes of cancer, tumor hypoxia has been considered as a potential therapeutic problem. In the stressful microenvironment condition, hypoxia inducible factor 1 (HIF1) is well known to mediate the transcriptional adaptation of cells to hypoxia and acts as a central player for the...

journal_title：Cancer letters

authors： Kim YH,Yoo KC,Cui YH,Uddin N,Lim EJ,Kim MJ,Nam SY,Kim IG,Suh Y,Lee SJ

更新日期：2014-11-01 00:00:00

abstract：:We examined the responsiveness of normal and neoplastic lung cells to agents which stimulate cAMP production. While their basal cAMP levels were similar, spontaneous in vitro transformant E9 cells and tumor-derived PCC4 cells produced much less cAMP in response to 1 microM isoproterenol compared to non-tumorigenic C10...

journal_title：Cancer letters

authors： Lange-Carter CA,Droms KA,Vuillequez JJ,Malkinson AM

更新日期：1992-12-24 00:00:00

abstract：:N-Nitrosodiethanolamine (NDE1A) was administered by gavage to male rats in single doses of 1000, 500 and 100 mg/kg body wt. More than 70% of a given dose was excreted unchanged in the urine, essentially within the first 24 h after exposure. This high excretion rate might explain the relatively low carcinogenic potenti...

journal_title：Cancer letters

authors： Preussmann R,Würtele G,Eisenbrand G,Spiegelhalder B

更新日期：1978-04-01 00:00:00

abstract：:Eighty samples of cervical invasive squamous cell carcinoma were examined for ras gene mutations using polymerase chain reaction (PCR) followed by restriction enzyme digestion. We found 28 (35%) cervical cancers contained ras mutations at H-ras codon 12, 49 (61%) at K-ras codon 12, and 5 (6%) at K-ras codon 13. There ...

journal_title：Cancer letters

authors： Wong YF,Chung TK,Cheung TH,Lam SK,Xu YG,Chang AM

更新日期：1995-08-16 00:00:00

abstract：:Oesophageal cancer is associated with high morbidity and mortality rates because it is highly invasive and prone to recurrence and metastasis, with a five-year survival rate of <20%. Therefore, there is an urgent need for new methods aimed at improving therapeutic intervention. Several studies have shown that targeted...

journal_title：Cancer letters

authors： Zhang Y,Liu S,Zhou S,Yu D,Gu J,Qin Q,Cheng Y,Sun X

更新日期：2021-01-01 00:00:00

abstract：:The present study evaluates the postnatal efficacy of Momordica charantia peel, pulp, seed and whole fruit extract via assessing the modulation in the biotransformation system enzymes of suckling neonates and lactating mice. The peel, seed or whole fruit extract of Momordica (100 microl/animal/day) independently induc...

journal_title：Cancer letters

authors： Singh A,Singh SP,Bamezai R

更新日期：1998-01-09 00:00:00

abstract：:Deregulation of cell metabolism is an established cancer hallmark that contributes to tumor initiation and progression, as well as tumor heterogeneity. In solid tumors, alterations in different metabolic pathways, including glycolysis, pentose phosphate pathway, glutaminolysis and fatty acid metabolism, support the hi...

journal_title：Cancer letters

authors： Miranda-Gonçalves V,Lameirinhas A,Henrique R,Baltazar F,Jerónimo C

更新日期：2020-05-01 00:00:00

abstract：:In a series of invasive ductal breast carcinoma, we investigated the status of chromosomal and intrachromosomal instability by fluorescence in situ hybridisation and determined the level of mRNA expression for two genes involved in the mitotic spindle checkpoint pathway, BUB1B and MAD2L1. All breast cancers demonstrat...

journal_title：Cancer letters

authors： Scintu M,Vitale R,Prencipe M,Gallo AP,Bonghi L,Valori VM,Maiello E,Rinaldi M,Signori E,Rabitti C,Carella M,Dallapiccola B,Altomare V,Fazio VM,Parrella P

更新日期：2007-09-08 00:00:00

abstract：:Epigenetic events have emerged as key mechanisms in the regulation of critical biological processes and in the development of a wide variety of human malignancies, including gastric cancer (GC), however precise gene targets of aberrant DNA methylation in GC remain largely unknown. Here, we have combined pyrosequencing...

journal_title：Cancer letters

authors： Balassiano K,Lima S,Jenab M,Overvad K,Tjonneland A,Boutron-Ruault MC,Clavel-Chapelon F,Canzian F,Kaaks R,Boeing H,Meidtner K,Trichopoulou A,Laglou P,Vineis P,Panico S,Palli D,Grioni S,Tumino R,Lund E,Bueno-de-Mesqui

更新日期：2011-12-01 00:00:00

abstract：:The effect of methoxsalen, the inhibitor of the hepatic mixed function oxidase, on the expression of liver cytochrome P450s was examined in rats. Administration of methoxsalen to rats significantly increased the hepatic content of P450 and activities of microsomal ethoxyresorufin O-deethylase (EROD), methoxyresorufin ...

journal_title：Cancer letters

authors： Gwang JH

更新日期：1996-12-03 00:00:00

abstract：:Synovial sarcoma is a relatively common soft tissue sarcoma with an aggressive clinical course. Although surgery is currently the first treatment modality, improvement of adjuvant chemotherapy is deemed essential to improve the clinical outcome. Nuclear factor-kappaB (NF-kappaB) is constitutively activated in various ...

journal_title：Cancer letters

authors： Horiuchi K,Morioka H,Nishimoto K,Suzuki Y,Susa M,Nakayama R,Kawai A,Sonobe H,Takaishi H,Ozaki T,Yabe H,Umezawa K,Toyama Y

更新日期：2008-12-18 00:00:00

abstract：:Colorectal cancer (CRC) is one of the most common neoplasms and a leading cause of death related to cancer worldwide. Hereditary nonpolyposis colorectal cancer (HNPCC) is the most frequent autosomal dominant predisposition to the development of CRC, accounting for approximately 2.5% of the total CRC burden in Spain. G...

journal_title：Cancer letters

authors： Castellví-Bel S,Castells A,Strunk M,Ferrández A,Piazuelo E,Milà M,Piñol V,Rodríguez-Moranta F,Andreu M,Lanas A,Piqué JM,Gastrointestinal Oncology Group of the Spanish Gastroenterological Association.

更新日期：2005-07-08 00:00:00

abstract：:In this study, we investigated the antitumor effects of deguelin in several human breast cancer cells in vitro and in vivo. Deguelin inhibited cell viability and the anchorage-dependent and anchorage-independent colony formation of triple-negative (MDA-MB-231 and MDA-MB-468) and triple-positive (MCF-7) breast cancer c...

journal_title：Cancer letters

authors： Suh YA,Kim JH,Sung MA,Boo HJ,Yun HJ,Lee SH,Lee HJ,Min HY,Suh YG,Kim KW,Lee HY

更新日期：2013-05-10 00:00:00

abstract：:Neoxanthin and fucoxanthin, which have the characteristic structure of 5,6-monoepoxide and an allenic bond, were previously found to reduce the viability of human prostate cancer cells most intensively among 15 dietary carotenoids tested. In the present study, the induction of apoptosis in PC-3 cells by these two caro...

journal_title：Cancer letters

authors： Kotake-Nara E,Asai A,Nagao A

更新日期：2005-03-18 00:00:00

abstract：:Liver microsomes from control and treated rats (P4501A, 2B, 2E1-induced) metabolize at variable metabolic rates eight N-nitroso-di-n-alkylamines, including five symmetrical (N-nitroso-dimethyl, -diethyl, -dipropyl, -dibutyl and -diamyl-amines) and four asymmetrical (N-nitrosomethylethyl, methylpropyl, methylbutyl, and...

journal_title：Cancer letters

authors： Bellec G,Goasduff T,Dreano Y,Menez JF,Berthou F

更新日期：1996-02-27 00:00:00

abstract：:A six-month bioassay in A/J mice was conducted to test the hypothesis that chronically inhaled mainstream cigarette smoke would either induce lung cancer or promote lung carcinogenicity induced by the tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Groups of 20 female A/J mice were ...

journal_title：Cancer letters

authors： Finch GL,Nikula KJ,Belinsky SA,Barr EB,Stoner GD,Lechner JF

更新日期：1996-02-06 00:00:00

abstract：:These studies examined the impact of dietary corn oil and its major constituent fatty acids on the occurrence of 7,12-dimethylbenz[a]anthracene (DMBA)-induced mammary DNA adducts. In study 1, rats were fed diets containing 5, 10 or 20% corn oil for 2 weeks prior to DMBA treatment (25 mg/kg). Mammary DNA adducts increa...

journal_title：Cancer letters

authors： Schaffer EM,Milner JA

更新日期：1996-09-10 00:00:00

abstract：:To investigate characteristic of lung adenocarcinoma growth behavior, we have established a cell line (rat lung cancer in Nara (RLCNR)) from a tumor induced by N-nitrosobis(2-hydroxypropyl)amine (BHP) in a rat. This clone shows an epithelial cell morphology and grows as sheets in culture with an approximate doubling t...

journal_title：Cancer letters

authors： Tsujiuchi T,Mori T,Amanuma T,Tanaka N,Tsutsumi M

更新日期：2005-01-10 00:00:00

abstract：:Epigenetics is defined as heritable changes in gene expression that occur without changes in DNA sequence. Major mechanisms of epigenetics are post-translational histone modifications such as reversible acetylation. Histone deacetylases (HDACs) maintain the acetylation level of histones but also act on non-histone sub...

journal_title：Cancer letters

authors： Schemies J,Sippl W,Jung M

更新日期：2009-08-08 00:00:00

abstract：:Tumor biopsies obtained from 25 Saudi Arab patients with nasopharyngeal carcinoma (NPC) were examined for the presence of Epstein-Barr virus (EBV) DNA detected by the polymerase chain reaction (PCR) and for the incidence of p53 mutations screened by a combination of PCR, single strand conformation polymorphism (SSCP) ...

journal_title：Cancer letters

authors： Nasrin N,Taiba K,Hannan N,Hannan M,al-Sedairy S

更新日期：1994-07-29 00:00:00

abstract：:Detection of novel tumor-related antigens and autoantibodies in cancer patients is expected to facilitate the diagnosis of early-stage malignant tumor and establish effective new immunotherapies. The purpose of this study was to identify novel tumor antigens in an esophageal squamous cell carcinoma (ESCC) cell line (T...

journal_title：Cancer letters

authors： Fujita Y,Nakanishi T,Miyamoto Y,Hiramatsu M,Mabuchi H,Miyamoto A,Shimizu A,Takubo T,Tanigawa N

更新日期：2008-05-18 00:00:00

abstract：:Fanconi Anemia has recently been associated with a high risk of head and neck squamous cell carcinoma (HNSCC). Inactivation of the Fanconi Anemia (FANC-BRCA) pathway via promoter methylation of the FANCF gene has been proposed to be responsible for variation in cisplatinum (CDDP) sensitivity seen in ovarian and HNSCCs...

journal_title：Cancer letters

authors： Snyder ER,Ricker JL,Chen Z,Waes CV

更新日期：2007-01-08 00:00:00