Abstract：
:We examined the responsiveness of normal and neoplastic lung cells to agents which stimulate cAMP production. While their basal cAMP levels were similar, spontaneous in vitro transformant E9 cells and tumor-derived PCC4 cells produced much less cAMP in response to 1 microM isoproterenol compared to non-tumorigenic C10 cells derived from normal mouse lung epithelium. Iodocyanopindolol binding studies indicated that both neoplastic lines contained fewer beta-adrenergic receptors than normal C10 cells. When receptors were bypassed via treatment with 10 pM cholera toxin, the pattern of cAMP-responsiveness was reversed; both neoplastic cell lines produced more cAMP than C10 cells. Direct stimulation of adenylate cyclase with 100 microM forskolin greatly increased cAMP concentrations in all three cell lines. These anomalies at both the receptor and G-protein levels in neoplastic lung epithelial cells may contribute to their deregulated growth.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Lange-Carter CA,Droms KA,Vuillequez JJ,Malkinson AMdoi
10.1016/0304-3835(92)90137-kkeywords:
subject
Has Abstractpub_date
1992-12-24 00:00:00pages
139-44issue
2-3eissn
0304-3835issn
1872-7980pii
0304-3835(92)90137-Kjournal_volume
67pub_type
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