Proteomics discovery of radioresistant cancer biomarkers for radiotherapy.

abstract：:In this study we have compared the anti-proliferative effects of transforming growth factor-beta (TGF-beta), N,N-dimethylformamide (DMF) and retinoic acid (RA) on a moderately-differentiated colon carcinoma cell line (JVC). TGF-beta, DMF and RA inhibited the anchorage-independent growth and induced morphological chang...

journal_title：Cancer letters

authors： Hoosein NM,Brattain DE,McKnight MK,Childress KE,Chakrabarty S,Brattain MG

更新日期：1988-06-15 00:00:00

abstract：:The mitochondrial genetic system is indispensable for the biosynthesis of the enzyme complexes involved in aerobic energy generation. Tetracyclines inhibit the expression of only the mitochondrial genes because they specifically block mitochondrial protein synthesis. A salient feature is that this inhibition occurs at...

journal_title：Cancer letters

authors： Kroon AM,Dontje BH,Holtrop M,Van den Bogert C

更新日期：1984-11-01 00:00:00

abstract：:Dietary retinyl palmitate was administered for 22-30 weeks in CD-1 mice which had been initiated with 0.15 mumol of 7,12-dimethylbenz[a]anthracene (DMBA) and promoted with 8 nmol of 12-O-tetradecanoylphorbol-13-acetate (TPA) twice weekly thereafter. This treatment resulted in a dose response in both the tumoricidal ca...

journal_title：Cancer letters

authors： Watson RR,Moriguchi S,Gensler HL

更新日期：1987-08-01 00:00:00

abstract：:This study demonstrates that mammalian cell targets (erythrocytes and tumour cells) may be sensitised to ultrasound using electric pulses and this combination treatment results in destruction of those cells in vitro. It further demonstrates that when a tumour mass is treated in vivo using combined electric field and u...

journal_title：Cancer letters

authors： Rollan Haro AM,Smyth A,Hughes P,Reid CN,McHale AP

更新日期：2005-05-10 00:00:00

abstract：:Myosin light-chain kinase (MLCK) plays a crucial role in the cell migration and tumor metastasis. Herein, we investigated the signaling pathways involved in MLCK using ML-7, a specific inhibitor of MLCK, in breast cancer cell proliferation and migration. Our data showed that reduction of MLCK in breast cancer cells me...

journal_title：Cancer letters

authors： Zhou X,Liu Y,You J,Zhang H,Zhang X,Ye L

更新日期：2008-11-08 00:00:00

abstract：:Antimutagenic activity of copper chlorophyllin against various carcinogenic mutagens was assayed with Drosophila genotoxicity tests, i.e., the wing spot test for detecting somatic cell mutations and the DNA repair test for detecting DNA damage. In these tests, Drosophila larvae were fed carcinogens together with chlor...

journal_title：Cancer letters

authors： Negishi T,Nakano H,Kitamura A,Itome C,Shiotani T,Hayatsu H

更新日期：1994-08-15 00:00:00

abstract：:We have examined the effect of theanine, a specific amino acid in green tea, on idarubicin (IDA)-induced antitumor activity and toxicity. In combination with theanine, IDA (0.25 mg/kg per day x4 days, a dose that does not show antitumor activity) had significant antitumor activity in P388-bearing mice. The IDA concent...

journal_title：Cancer letters

authors： Sadzuka Y,Sugiyama T,Sonobe T

更新日期：2000-10-01 00:00:00

abstract：:We investigated the anticancer activity of erufosine in oral squamous carcinoma cell lines in terms of cell proliferation, colony formation, induction of autophagy/apoptosis, cell cycle and mTOR signaling pathway. Erufosine showed dose-dependent cytotoxicity in all cell lines, it induced autophagy as well as apoptosis...

journal_title：Cancer letters

authors： Kapoor V,Zaharieva MM,Das SN,Berger MR

更新日期：2012-06-01 00:00:00

abstract：:The induction of differentiation of SENCAR murine granulocyte-macrophage precursor cells (GM-CFU) by the tumor-promoting phorbol diester 12-O--tetradecanoyl-phorbol-13-acetate (TPA) was inhibited by agents reported to inhibit specific aspects of arachidonic acid metabolism. These agents included phospholipase A2 inhib...

journal_title：Cancer letters

authors： Baxter CS,Lawrence AT

更新日期：1987-11-01 00:00:00

abstract：:Effects of eight heterocyclic amines (HCAs) on pancreatic duct carcinogenesis were investigated in a rapid production model in hamsters. N-Nitrosobis(2-oxopropyl)amine (BOP) was given to effect initiation, followed by augmentation pressure consisting of four daily i.p. injections of 500 mg/kg DL-ethionine, a choline-d...

journal_title：Cancer letters

authors： Yoshimoto M,Tsutsumi M,Iki K,Sasaki Y,Tsujiuchi T,Sugimura T,Wakabayashi K,Konishi Y

更新日期：1999-09-01 00:00:00

abstract：:D-Tryptophan-6-luteinizing hormone-releasing hormone (D-Trp6-LH-RH) applied from day -8 to day +15 before and after administration of the nitrosourea analog, N,N'-bis[N-(2-chloroethyl)-N-nitrosocarbamoyl]cysteamine (CNCC), favored bone marrow restoration, as independently evaluated by 3 observers in a double-blind fas...

journal_title：Cancer letters

authors： Lemaigre G,Maral R,Bourut C,Chenu E,Blazsek I,Mauvernay Y,Schally AV,Mathé G

更新日期：1984-12-01 00:00:00

abstract：:To clarify the suitability of a newborn-mouse carcinogenesis assay to detect tumor-promoting activities of carcinogens, the non-genotoxic hydroquinone (HQ) and genotoxic 1,1-dimethylhydrazine (UDMH) were administered to mice during the promotion stage after treatment with 1-methyl-1-nitrosourea (MNU) (20 mg/kg body wt...

journal_title：Cancer letters

authors： Tamura T,Shibutani M,Toyoda K,Shoda T,Takada K,Uneyama C,Takahashi M,Hirose M

更新日期：1999-08-23 00:00:00

abstract：:The biological characteristic cell locomotion and invasion, melanin content, metalloproteinases and telomerase activity were studied in a parental mouse melanoma cell line B16 and two descendents B16BL6 and B16F10. The invasive potential of melanoma cells was assayed in a transwell cell culture chamber. Melanin conten...

journal_title：Cancer letters

authors： Zhao W,Liu H,Xu S,Entschladen F,Niggemann B,Zänker KS,Han R

更新日期：2001-01-01 00:00:00

abstract：:Immunometabolism, which has important implications in cancer biology, has emerged as a major regulator of different immune cell types. Various factors that integrate metabolic switches within immune cells with signal directed program that promote or inhibit their functions remain largely unidentified. Furthermore, sex...

journal_title：Cancer letters

authors： Zi Xu YX,Ande SR,Mishra S

更新日期：2018-02-28 00:00:00

abstract：:6-(1-Hydroxyimino-4-methylpentyl)5,8-dimethyoxy 1,4-naphthoquinone S-52 (DMNQ S-52) was reported to have cytotoxic activity against L1210 leukemia cells. In the present study, we investigated the apoptotic mechanism of DMNQ S-52 in vitro and in vivo in murine solid cancer cells. DMNQ S-52 exerted cytotoxicity against ...

journal_title：Cancer letters

authors： Lee SJ,Sakurai H,Koizumi K,Song GY,Bae YS,Kim HM,Kang KS,Surh YJ,Saiki I,Kim SH

更新日期：2006-02-20 00:00:00

abstract：:Third generation bisphosphonates (BPs), including YM175 and YM529, are known to inhibit bone resorption. The aim of this study was to evaluate the anti-tumor effects of these drugs on murine osteosarcoma cell lines, in terms of proliferation and apoptosis. We found that both YM175 and YM529 strongly inhibited the in v...

journal_title：Cancer letters

authors： Horie N,Murata H,Nishigaki Y,Matsui T,Segawa H,Nogawa M,Yuasa T,Kimura S,Maekawa T,Fushiki S,Kubo T

更新日期：2006-07-08 00:00:00

abstract：:Telomerase plays an important role in the maintenance of telomere ends in normal and tumor cells and ectopic expression can immortalize human bronchial epithelial (HBE) cells. We assessed telomerase activation, growth properties and methylation status in the hTERT promoter in a panel of HBE cell cultures in relation t...

journal_title：Cancer letters

authors： Yim HW,Slebos RJ,Randell SH,Umbach DM,Parsons AM,Rivera MP,Detterbeck FC,Taylor JA

更新日期：2007-02-08 00:00:00

abstract：:Human cytolytic fusion proteins (hCFPs) offer a promising immunotherapeutic approach for the treatment of solid tumors, avoiding the immunogenicity and undesirable side-effects caused by immunotoxins derived from plants or bacteria. The well-characterized human serine protease granzyme B has already been used as a the...

journal_title：Cancer letters

authors： Niesen J,Hehmann-Titt G,Woitok M,Fendel R,Barth S,Fischer R,Stein C

更新日期：2016-05-01 00:00:00

abstract：:Conventional chemotherapies have some limitations, including the lack of selectivity, high toxicity to normal tissues, multidrug resistance, and tumor relapse. Recently, great progress was made in immunotherapies for anticancer research, with bacteria-mediated cancer therapy one of the most promising approaches among ...

journal_title：Cancer letters

authors： Guo Y,Chen Y,Liu X,Min JJ,Tan W,Zheng JH

更新日期：2020-01-28 00:00:00

abstract：:The underlying molecular mechanism of lung cancer drug resistance is poorly understood. The mediator of endoplasmic reticulum stress CHOP (DNA damage inducible transcript 3) promotes stress-induced apoptosis and appears to function as a transcription factor in multiple diseases. However, its potential contributions to...

journal_title：Cancer letters

authors： Tan W,Liao Y,Qiu Y,Liu H,Tan D,Wu T,Tang M,Zhang S,Wang H

更新日期：2018-08-01 00:00:00

abstract：:In this study, we demonstrated that thrombin activates protein kinase C (PKC), mitogen activated protein kinases (MAP kinases), transcription factor nuclear factor-kappa B (NF-kappa B), and cAMP-dependent protein kinase (PKA) in the human renal carcinoma cell line A-498. In addition, it enhanced the migratory capacity...

journal_title：Cancer letters

authors： Kaufmann R,Junker U,Junker K,Nuske K,Ranke C,Zieger M,Scheele J

更新日期：2002-06-28 00:00:00

abstract：:The selectivity of photodynamic therapy (PDT) derived from the tailored accumulation of photosensitizing drug (photosensitizer; PS) in the tumor microenvironment (TME), and from local irradiation, turns it into a "magic bullet" for the treatment of resistant tumors without sparing the healthy tissue and possible adver...

journal_title：Cancer letters

authors： Pucelik B,Sułek A,Barzowska A,Dąbrowski JM

更新日期：2020-11-01 00:00:00

abstract：:Oncogenic transformation of mouse C3H10T1/2 cells induced by X-rays was suppressed in the presence of extract of Rooibos tea, Aspalathus linealis. Transformation was reduced with increased concentration of the extract, so that at an extract concentration of 10%, transformation incidence was similar to the spontaneous ...

journal_title：Cancer letters

authors： Komatsu K,Kator K,Mitsuda Y,Mine M,Okumura Y

更新日期：1994-02-28 00:00:00

abstract：:Matrilysin and gelatinase A, B mRNA expressions were examined in colorectal tumors. Matrilysin mRNA was observed exclusively in tumors, while the others were also found in normal mucosa surrounding tumors. Further analysis revealed that colorectal adenomas with severe dysplasia, not with mild dysplasia, expressed matr...

journal_title：Cancer letters

authors： Ishikawa T,Ichikawa Y,Mitsuhashi M,Momiyama N,Chishima T,Tanaka K,Yamaoka H,Miyazakic K,Nagashima Y,Akitaya T,Shimada H

更新日期：1996-10-01 00:00:00

abstract：:Cancer-associated fibroblasts (CAFs) are the predominant cell type in tumor microenvironment (TM) and featured with the distinct energy metabolism reprogramming (EMR) phenotype caused by many factors such as hypoxia and growth factors. The EMR of CAFs plays a key role in biological behaviors of cancer cells including ...

journal_title：Cancer letters

authors： Tang S,Yang L,Tang X,Liu M

更新日期：2014-10-28 00:00:00

abstract：:For biochemical modulation, components of green tea have been shown to be useful modulators in combination with doxorubicin (DOX). We have confirmed that theanine enhances the antitumor activity of DOX due to inhibition of DOX efflux from tumor cells. Because theanine is a glutamate analogue, we found that it is assoc...

journal_title：Cancer letters

authors： Sadzuka Y,Yamashita Y,Sugiyama T,Sonobe T

更新日期：2002-05-28 00:00:00

abstract：:Many studies have shown that the activation of beta-catenin signaling can promote oncogenesis, and it is therefore of interest to find agents that modulate this pathway. Recent work has shown using B lymphoma cells that infection by Epstein-Barr virus (EBV) and expression of its latent membrane protein (LMP)-1, cause ...

journal_title：Cancer letters

authors： Min HJ,Cho IR,Srisuttee R,Park EH,Cho DH,Ahn JH,Lee IS,Johnston RN,Oh S,Chung YH

更新日期：2009-04-18 00:00:00

abstract：:Interferon induced transmembrane protein 1 (IFITM1) belongs to a family of interferon stimulated genes (ISGs) that is associated with tumor progression and DNA damage resistance; however, its role in endocrine resistance is not known. Here, we correlate IFITM1 expression with clinical stage and poor response to endocr...

journal_title：Cancer letters

authors： Lui AJ,Geanes ES,Ogony J,Behbod F,Marquess J,Valdez K,Jewell W,Tawfik O,Lewis-Wambi J

更新日期：2017-07-28 00:00:00

abstract：:Receptors for all classes of steroid hormones were identified in cytosols of adenocarcinoma of the lung. In contrast, the incidence of receptor in squamous cell carcinoma was limited and small cell carcinomas appeared devoid of receptor. Receptor binding was of high affinity, saturable and localized to the 8, 6-7 and ...

journal_title：Cancer letters

authors： Chaudhuri PK,Thomas PA,Walker MJ,Briele HA,Das Gupta TK,Beattie CW

更新日期：1982-09-01 00:00:00

abstract：:Development of drug resistance to standard chemotherapy is a common phenomenon that leads to poor prognosis in patients. Thus, novel agents that can attenuate chemoresistance are urgently needed. Therefore, we analyzed whether isorhamnetin (IH), a 3'-O-methylated metabolite of quercetin, can enhance the potential effi...

journal_title：Cancer letters

authors： Manu KA,Shanmugam MK,Ramachandran L,Li F,Siveen KS,Chinnathambi A,Zayed ME,Alharbi SA,Arfuso F,Kumar AP,Ahn KS,Sethi G

更新日期：2015-07-10 00:00:00