Abstract：
:Recent work has demonstrated that oncogenes and tumor suppressor proteins regulate apoptotic cell death. Current efforts are therefore directed at determining how they exert their effects. It appears that oncogenes can control activation of the apoptosis endonuclease(s) either by regulating the signal(s) that trigger the process or via effects on expression and/or activation of key components of the effector machinery, including the endogenous endonuclease itself. This article summarizes the available information on the biochemical mechanisms underlying the effects of oncogenes on endogenous endonuclease activation and presents models to explain the observation that they also regulate alternative cell fates such as cell proliferation and differentiation.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
McConkey DJ,Fernandez A,Trent J 2nd,Ananthaswamy HNdoi
10.1016/0304-3835(95)03835-ksubject
Has Abstractpub_date
1995-07-20 00:00:00pages
9-16issue
1eissn
0304-3835issn
1872-7980pii
030438359503835Kjournal_volume
94pub_type
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