Abstract：
:The highly conserved RNA-binding protein, Lin28, is involved in many biological processes, including development, reprogramming, pluripotency, and metabolism. Importantly, Lin28 functions as an oncogene, promoting tumor progression and metastasis in various human cancers. Lin28 can regulate gene expression either by directly binding to mRNAs or by blocking microRNA biogenesis, and the underlying mechanisms include Let-7-dependent and Let-7-independent modes of action. Recent evidence shows that Lin28 also plays a fundamental role in immunity. The roles of Lin28 in disease are complex and require characterization of its physiological functions in cancer and immunological contexts. Here we review emerging information on the role of Lin28 in cancer and immunity and the molecular mechanisms it uses. We discuss our present knowledge of the system and highlight remaining mysteries related to the functions of this small RNA-binding protein. This knowledge may lead to Lin28 becoming a diagnostic marker for cancer or immune-related diseases and a possible therapeutic target.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Jiang S,Baltimore Ddoi
10.1016/j.canlet.2016.02.050subject
Has Abstractpub_date
2016-05-28 00:00:00pages
108-113issue
1eissn
0304-3835issn
1872-7980pii
S0304-3835(16)30128-8journal_volume
375pub_type
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